Evolutionary deletions within the SARS-CoV-2 genome as signature trends for virus fitness and adaptationMinireview Published on 2024-01-132024-09-05 Journal: Journal of virology [Category] update2024, [키워드] deletions evolutionary mechanisms SARS-CoV-2 structural mutations viral adaptation [DOI] 10.1128/jvi.01404-23 PMC 바로가기 [Article Type] Minireview
SARS-CoV-2 intra-host evolution during prolonged infection in an immunocompromised patientArticle Published on 2022-09-012022-11-16 Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Amino acid approach changes in chronic infection Combination deep sequencing deletions demonstrated Evolution favor Genetic Host immune evasion Immunocompromised immunocompromised individual Immunocompromised patient Infection intra-host evolution investigated Mutation Nasopharyngeal swab new SARS-CoV-2 Patient Prolonged Prolonged infection Protein SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 lineage Sequencing suggested the SARS-CoV-2 the Spike variant variants with HIV [DOI] 10.1016/j.ijid.2022.06.023 PMC 바로가기
Rapid repeat infection of SARS-CoV-2 by two highly distinct delta-lineage viruses2개의 매우 구별되는 델타 계통 바이러스에 의한 SARS-CoV-2의 빠른 반복 감염Case Reports Published on 2022-09-012022-09-11 Journal: Diagnostic microbiology and infectious disease [Category] COVID19(2023년), SARS, 변종, [키워드] Amino acid amino acid substitutions change conditions Deletion deletions Delta delta variant genomic had no Health increasingly individual Infection Lineage mutations Patient positive Protective Protein question Rapid Reinfection SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants singular Spike protein the Spike variant virus [DOI] 10.1016/j.diagmicrobio.2022.115747 PMC 바로가기 [Article Type] Case Reports
Genomic Surveillance of SARS-CoV-2 in the Southern Province of Zambia: Detection and Characterization of Alpha, Beta, Delta, and Omicron Variants of ConcernArticle Published on 2022-08-242022-11-16 Journal: Viruses [Category] SARS, 변종, 유전자 메커니즘, 치료기술, [키워드] acute respiratory syndrome African Alpha variant analysed Analysis B.1.1.7 B.1.351 Beta characterization circulation concern conducted coronavirus country COVID-19 deletions Delta detection Epidemiology European Evidence Genome genomic impacted increased risk insertions International Local Missense mutations Mutation mutations non-coding region omicron pandemic positioned predominant Region SARS-CoV-2 significantly spike mutations stop codon Surveillance synonymous Transmission variant variants of concern VoC VOCs whole genome whole-genome sequencing Zambia Zimbabwe [DOI] 10.3390/v14091865 PMC 바로가기
Spread of endemic SARS-CoV-2 lineages in Russia before April 20212021년 4월 이전 러시아의 고유 SARS-CoV-2 계통 확산Article Published on 2022-07-202022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 변종, [키워드] Alpha B.1.1 B.1.1.7 B.1.351 Beta characterized Combination combinations country COVID-19 cases COVID-19 pandemic Deletion deletions delta variant Endemic Evidence Frequency highest hotspot identify indicate joint Lineage lineages Mutation mutations notable NSP6 ORF1a P.1 pandemic PCR testing remained Russia SARS-CoV-2 lineage spike glycoprotein Spread spring summer the epidemic Transmissibility variant variants variants of concern [DOI] 10.1371/journal.pone.0270717 PMC 바로가기 [Article Type] Article
Applying fluorescent dye assays to discriminate Escherichia coli chlorhexidine resistance phenotypes from porin and mlaA deletions and efflux pumps Research Published on 2022-07-152022-10-05 Journal: Scientific Reports [Category] 유전자 메커니즘, [키워드] alteration Applying assays AST caused Cell cells change Concentration controls deleted deleterious mutation Deletion deletion mutants deletions E. coli E. coli cell Escherichia coli examination fluorescent greater identify isolate K-12 membrane integrity Microscopy over-expressed overexpression phenotype resistance gene resistance mechanisms Result SEM shown susceptibility tested transformant Transport [DOI] 10.1038/s41598-022-15775-6 [Article Type] Research
Whole-genome analysis and mutation pattern of SARS-CoV-2 during first and second wave outbreak in Gwangju, Republic of Korea대한민국 광주에서 1차 및 2차 유행 중 SARS-CoV-2의 전체 게놈 분석 및 돌연변이 패턴Article Published on 2022-07-052022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] Analysis analyzed Cell culture circulating clade clinical clinical samples collected conducted Culture Deletion deletions determine dominant feature genetic diversity genomic genomic alteration high viral load in-depth analysis indicate Missense mutated Mutation Next-generation sequencing nucleic acid Nucleic acid purification outbreak Pathogenesis pathogenesis of SARS-CoV-2 Patient phylogenetic analyses Phylogenetic analysis Point mutation Proteins Region regions Research SARS-CoV-2 SARS-CoV-2 genome sequence SARS-CoV-2 genome sequences SARS-CoV-2 isolates SARS-CoV-2 pathogenesis second wave significant difference South Korea statistical analysis therapeutic Viral load was performed whole genome [DOI] 10.1038/s41598-022-14989-y PMC 바로가기 [Article Type] Article
Investigation of the binding and dynamic features of A.30 variant revealed higher binding of RBD for hACE2 and escapes the neutralizing antibody: A molecular simulation approachA.30 변이체의 결합 및 동적 특징 조사 결과 hACE2에 대한 RBD의 더 높은 결합 및 중화 항체 탈출: 분자 시뮬레이션 접근Article Published on 2022-07-012022-09-11 Journal: Computers in biology and medicine [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] A.30 variant ACE2 approach atomic binding binding affinity binding free energy calculated complex complexes coronavirus coronavirus disease cross-protective Deletion deletions Delta demonstrated dissociation Dissociation constant docking result domain drug Effects evade feature Free free energy global pandemic greater hACE2 help Host immune response Interaction interactions investigation mAb molecular Molecular simulation monoclonal antibodies mutated Mutation N terminal domain Neutralizing Neutralizing antibodies NTD omicron Omicron variants protein-protein docking RBD RBD complex reduce reported residue robust salt-bridge SARS-CoV-2 Simulation spike gene Spike protein Spread Substitution the spike protein variant variants variants of SARS-CoV-2 wild type [DOI] 10.1016/j.compbiomed.2022.105574 PMC 바로가기 [Article Type] Article
Omicron – The new SARS-CoV-2 challenge?오미크론 - 새로운 SARS-CoV-2 도전?Review Published on 2022-07-012022-09-11 Journal: Reviews in Medical Virology [Category] COVID19(2023년), SARS, 변종, [키워드] antibody B.1.1.529 binding circulating clade concerning country death death rate Deletion deletions described dominant dominant variant Effectiveness Efficiency Europe GISAID Health Organization high infectiousness highest highlight in some inhibitor maintain Mutation new SARS-CoV-2 Nextstrain number of infected omicron proportion Region replacing reported responsible rises SARS-CoV-2 SARS-CoV-2 virus sequence spike mutations Spike protein Spread Surveillance the SARS-CoV-2 the spike protein therapy Transmissibility Vaccine Vaccine efficiency variant variants variants of concern virus VoC VOCs World Health Organization Wuhan [DOI] 10.1002/rmv.2358 PMC 바로가기 [Article Type] Review
First cases of infection with the 21L/BA.2 Omicron variant in Marseille, France프랑스 마르세유에서 21L/BA.2 오미크론 변종 첫 감염 사례Article Published on 2022-07-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, [키워드] Amino acid amino acid substitution amino acid substitutions Clinical outcome Cluster country deletions Denmark deviation diagnosed distribution emergence England facilitate flattening France Genome genomes incidence Infection initial Interaction Marseille MONITOR N-terminal domain Nepal Next-generation sequencing nucleotide nucleotide substitution nucleotide substitutions omicron Omicron variant Phylogeny predominant qPCR remained resulting SARS-CoV-2 Singapore South Africa southern France Spike protein Surveillance the spike protein Travel variant viral genome viral genomes [DOI] 10.1002/jmv.27695 PMC 바로가기 [Article Type] Article