Discovery of 2-deoxy glucose surfaced mixed layer dendrimer: a smart neuron targeted systemic drug delivery system for brain diseasesResearch Paper Published on 2024-05-192024-09-05 Journal: Theranostics [Category] update2024, [키워드] dendrimer drug conjugate nanotherapeutics neuron targeting non-invasive brain targeting Targeted drug delivery [DOI] 10.7150/thno.95476 PMC 바로가기 [Article Type] Research Paper
Inorganic nanoparticle-cored dendrimers for biomedical applications: A reviewReview Article Published on 2024-04-162024-09-05 Journal: Heliyon [Category] update2024, [키워드] biomedicine dendrimer Hybrid nanomaterials Inorganic nanoparticles [DOI] 10.1016/j.heliyon.2024.e29726 PMC 바로가기 [Article Type] Review Article
SARS-CoV-2 Fusion Peptide Conjugated to a Tetravalent Dendrimer Selectively Inhibits Viral InfectionArticle Published on 2023-12-172024-09-05 Journal: Pharmaceutics [Category] update2024, [키워드] dendrimer fusion fusion peptide inhibitors peptide SARS-CoV-2 spike viral fusion proteins [DOI] 10.3390/pharmaceutics15122791 PMC 바로가기 [Article Type] Article
Astodrimer sodium antiviral nasal spray for reducing respiratory infections is safe and well tolerated in a randomized controlled trial호흡기 감염 감소를 위한 아스토드리머 나트륨 항바이러스 비강 스프레이는 무작위 대조 시험에서 안전하고 내약성이 우수합니다.Randomized Controlled Trial Published on 2022-06-172022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 임상, 치료기술, 치료제, [키워드] absorbed Absorption Administered administration adverse event All participants Antiviral applied clinical clinical investigation clinical trial clinically Cohort Community community acquired dendrimer double-blinded Effects examination finding examination findings exploratory exposure to followed by four times daily Frequency healthy volunteer help in vitro Infection initial intensity Intensive Mild nasal Nasal cavity nasal mucosa Nasal spray New nostril occurred other respiratory virus Other respiratory viruses participant Placebo placebo-controlled primary endpoint product Randomized Randomized controlled trial receiving reduce reducing Registered registry respiratory infection respiratory virus Respiratory virus infections respiratory viruses Safe safety population SARS-CoV-2 serious AEs severity shown sodium spray Spread systemically TEAE TEAEs Tolerability Treatment Trial registration utility vaginal mucosa Viral load virucidal Withdrawal [DOI] 10.1038/s41598-022-14601-3 PMC 바로가기 [Article Type] Randomized Controlled Trial
Functionalized Dendrimer Platforms as a New Forefront Arsenal Targeting SARS-CoV-2: An OpportunityReview Published on 2021-09-182022-10-28 Journal: Pharmaceutics [Category] COVID-19, [키워드] acute respiratory syndrome anti-inflammatory drug antiviral drug approach approved approved drug arsenal candidate caused clinical trial coronavirus coronavirus disease coronavirus SARS-CoV-2 COVID-19 COVID-19 disease COVID-19 infection COVID-19 pandemic decrease dendrimer dendrimers develop drug FDA food IMPROVE Nanotechnology New opportunity pandemic pro-inflammatory cytokines repurposing strategy SARS-CoV-2 targeting the cytokine storm the patient transmission of SARS-CoV-2 Vaccine [DOI] 10.3390/pharmaceutics13091513 PMC 바로가기 [Article Type] Review
Protective Effects of Astodrimer Sodium 1% Nasal Spray Formulation against SARS-CoV-2 Nasal Challenge in K18-hACE2 MiceK18-HACE2 마우스에서 SARS-COV-2 코 챌린지에 대한 아스 토드리머 나트륨 1% 코 스프레이 제제의 보호 효과Article Published on 2021-08-202022-08-31 Journal: Viruses [Category] MERS, SARS, 치료기술, 치료제, [키워드] administration animal animal model animals anti-SARS-CoV-2 Antiviral astodrimer blocked Brain challenge chemokine COVID-19 Cytokines Day dendrimer detectable Effect Efficacy Formulation hACE2 IL-1 IL-1α IL-1β IL-6 Incubation infected intranasally Infection Infectious virus intranasally K18-hACE2 K18-hACE2 mice lack liver lung MCP-1 nasal Nasal cavity Nasal spray neutralisation pathogen PBS Post-infection pro-inflammatory cytokine pro-inflammatory cytokines product PROTECT reduced reducing reduction reduction in SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication secretion serum severity of COVID-19 significantly sodium SPL7013 spray Strategy TGFβ These data TNFα Trachea treated Treatment undetectable Viraemia Viral viral genome viral replication viral shedding virus virus replication virus transmission was used were infected [DOI] 10.3390/v13081656 PMC 바로가기 [Article Type] Article
Developments in Treatment Methodologies Using Dendrimers for Infectious DiseasesReview Published on 2021-05-312022-10-30 Journal: Molecules [Category] COVID-19, SARS, [키워드] antibody Antimicrobial therapy Antiviral agents antiviral therapy Bacteria biochemical Compound contrast agent dendrimer dendrimers development diagnostic diagnostics Diseases drug delivery genetic material Infectious disease Infectious diseases macromolecules medium methodology MRI Nanoparticles parasites peptide polymers potential therapy structural property substrate therapeutic Transport Vaccine viruses [DOI] 10.3390/molecules26113304 PMC 바로가기 [Article Type] Review
Droplet Microarray Based on Nanosensing Probe Patterns for Simultaneous Detection of Multiple HIV Retroviral Nucleic Acids여러 HIV 레트로바이러스 핵산의 동시 검출을 위한 나노센싱 프로브 패턴을 기반으로 하는 액적 마이크로어레이Article Published on 2020-12-162022-09-11 Journal: ACS applied materials & interfaces [Category] SARS, 치료기술, 치료제, [키워드] 2D MoS2 nanosheets acid Adsorption demonstrated dendrimer detection droplet droplet microarray (DMA) energy transfer FIVE fluorescent fluorescent dye fluorescent resonance energy transfer (FRET) HIV HIV nucleic acids HIV-1 HIV-2 Human immunodeficiency virus human immunodeficiency virus-2 hybridized immunodeficiency Influenza influenza A Influenza A) limit of detection M gene Microarray molybdenum Multiple multiplex N gene N genes nucleic acid nucleic acids omniphobic. pattern platform probe proof proof of concept retroviral separated Simultaneous small sample size Viral viral gene viral genes viral infection viral nucleic acid viral nucleic acids weakening [DOI] 10.1021/acsami.0c16146 PMC 바로가기 [Article Type] Article
A pilot study of the antiviral activity of anionic and cationic polyamidoamine dendrimers against the Middle East respiratory syndrome coronavirusShort Communication Published on 2020-05-082022-11-01 Journal: Journal of medical virology [Category] Coronavirus, Fulltext, MERS, [키워드] added anionic Antiviral antiviral activity Antiviral agents antivirals cationic cause cell cultures Consequences coronavirus CoV decrease dendrimer effective group IMPROVE Infection intrinsic investigated MERS Middle East outcome pilot study research and analysis methods respiratory syndrome coronavirus sodium Vero cells viral disease virus virus classification were used [DOI] 10.1002/jmv.25928 PMC 바로가기 [Article Type] Short Communication
Protecting capacity against malaria of chemically defined tetramer forms based on the Plasmodium falciparum apical sushi protein as potential vaccine componentsArticle Published on 2014-08-152024-08-29 Journal: Biochemical and Biophysical Research Communications [Category] 말라리아, [키워드] Antimalarial-vaccine dendrimer macromolecule PfASP Plasmodium