Epistasis at the SARS-CoV-2 Receptor-Binding Domain Interface and the Propitiously Boring Implications for Vaccine Escape
SARS-CoV-2 수용체 결합 도메인 인터페이스에서의 상위성과 백신 탈출에 대한 지루한 의미
Article
[키워드] ACE2
acute respiratory syndrome
acute respiratory syndrome coronavirus
acute respiratory syndrome coronavirus 2
antibody
appear
approach
binding site
closely resemble
Complete
coronavirus
COVID-19 pandemic
Delta
delta variant
destabilize
dominance
Effect
Efficacy
emergence
epistasis
escape
escape mutants
escape mutation
Evolution
Gamma
Gamma variant
host receptor
include
Interaction
interface
majority
multiple mutation
mutants
Mutation
mutations
neutralizing antibody
omicron
Omicron variant
Omicron variants
overlap
Protein
protein structure
protein structure modeling.
RBD
RBD mutation
RBD mutations
RBD-ACE2
Receptor-binding domain
reduce
reduced
repertoire
respiratory
resulting
risk
Rosetta
SARS-CoV-2
SARS-CoV-2 spike
SARS-CoV-2 virus
severe acute respiratory syndrome Coronavirus
single mutant
Spike protein
the RBD
the receptor-binding domain
the SARS-CoV-2
the spike protein
unlikely
Vaccine
vaccine efficacy
Vaccines
variant
variants
variants of SARS-CoV-2
virus
wild type
wild-type SARS-CoV-2
[DOI] 10.1128/mbio.00135-22 PMC 바로가기 [Article Type] Article
[DOI] 10.1128/mbio.00135-22 PMC 바로가기 [Article Type] Article