Ultrastructural examination of lung “cryobiopsies” from a series of fatal COVID-19 cases hardly revealed infected cells일련의 치명적인 COVID-19 사례에서 폐 "냉동생검"의 미세구조 검사는 감염된 세포를 거의 드러내지 않음Article Published on 2022-05-012022-09-11 Journal: Virchows Archiv [Category] COVID19(2023년), SARS, 치료기술, [키워드] accumulation aggregates alveolar alveolar damage alveolar epithelium Analysis Autopsy caused Cell cell types cells coronavirus COVID-19 patient COVID-19 patients death Detachment diffuse Diffuse alveolar damage electron electron microscopy Endothelium erythrocytes Extracellular fatal COVID-19 FIBRIN fixation fixed granulocyte Histopathology hyaline membrane hyaline membranes hyperplasia immune impairment IMPROVE infected cell investigated latency leukocyte leukocytes lung lung damage macrophages mechanisms Microscopy neutrophilic Particle Patient Region Replication respiratory distress Respiratory distress syndrome Sample SARS‐CoV‐2 Stage Stress stress response the disease the patient these cell These cells Thin section thrombocyte Thrombocytes tissue Ultrastructural analysis ventilated patient ventilated patients virus Virus particle. [DOI] 10.1007/s00428-022-03308-5 PMC 바로가기 [Article Type] Article
Trends in the Clinical Presentation of Primary Rhegmatogenous Retinal Detachments During the First Year of the COVID-19 PandemicObservational Study Published on 2022-05-012022-10-05 Journal: American journal of ophthalmology [Category] 임상, [키워드] clinical Cohort cohort patient consecutive patient coronavirus disease COVID-19 COVID-19 pandemic demographic demonstrated Detachment disease evaluate the effect Factor Final Follow-up greater logarithm median Observational cohort study outcome outcomes pandemic Patient patients treated presentation presenting proliferative vitreoretinopathy Retinal retrospective Rhegmatogenous retinal detachment significant increase significantly significantly higher treated trend visual acuity Year [DOI] 10.1016/j.ajo.2021.11.017 PMC 바로가기 [Article Type] Observational Study
Bean Extract-Based Gargle for Efficient Diagnosis of Active COVID-19 Infection Using Rapid Antigen Tests신속한 항원 테스트를 사용하여 활성 COVID-19 감염의 효율적인 진단을 위한 콩 추출물 기반 가글Research Article Published on 2022-02-162022-09-10 Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] Ag-RDT Ag-RDTs Alpha alpha and delta variants alternative analyzed Antigen Asymptomatic Bean canavalin clinical trial Concentration COVID-19 COVID-19 cases COVID-19 patient COVID-19 patients Delta delta variant Delta variants Detachment Detection sensitivity diagnostic diagnostic test domain early diagnosis efficient ENhance evaluated Evidence gargle hACE2 healthy individual healthy individuals ingredient initial intermolecular interaction intermolecular interactions less management Mass screening Nasopharyngeal swab nasopharyngeal swabs noninvasive NPs oral virus Patient patients hospitalized Physicochemical properties Rapid Rapid diagnostic test RDTs RT-PCR saliva specimen saliva specimens salivary SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 spike proteins SARS-CoV-2 variant screening process sensitivities sensitivity significantly Specificities specificity Spike proteins symptomatic symptomatic and asymptomatic Test tested the SARS-CoV-2 variants Viral Viral detection virus [DOI] 10.1128/spectrum.01614-21 PMC 바로가기 [Article Type] Research Article
The Role of Off-Job Crafting in Burnout Prevention during COVID-19 Crisis: A Longitudinal StudyArticle Published on 2022-02-142022-10-29 Journal: International Journal of Environmental Research an [Category] Coronavirus, COVID19(2023년), MERS, SARS, [키워드] Analysis Autonomy buffer Burnout collected correlated COVID-19 COVID-19 crisis COVID-19 pandemic Detachment dimension DRAMMA Employees examined Germany less lockdown longitudinal male mechanism off-job crafting pandemic pre-post COVID-19 study prevention questionnaire Regression Relaxation reported Research role significantly Switzerland [DOI] 10.3390/ijerph19042146 PMC 바로가기 [Article Type] Article
Mechanical activation of spike fosters SARS-CoV-2 viral infection스파이크의 기계적 활성화는 SARS-CoV-2 바이러스 감염을 촉진합니다Article Published on 2021-08-312022-09-11 Journal: Cell Research [Category] MERS, SARS, 변종, 진단, [키워드] accelerate ACE2 ACE2 binding Activation Anti-S1 antibody binding binding domain blocking antibody caused complex convalescent COVID-19 patient convalescent COVID-19 patients COVID-19 pandemic D614G Detachment domain faster force host cell host cell membrane Host receptors Invasion Mechanical Molecular biology mutant Neutralizing outbreak Prevent Receptor-binding domain recognize reduce Rotation S1 subunit S1/S2 S2 subunit SARS-CoV-2 SARS-CoV-2 viral infection SARS2 Spike protein structural biology tensile tensile force therapeutic strategy variant Viral viral entry [DOI] 10.1038/s41422-021-00558-x PMC 바로가기 [Article Type] Article
Internet-based stress recovery intervention FOREST for healthcare staff amid COVID-19 pandemic: study protocol for a randomized controlled trialCOVID-19 대유행 중 의료진을 위한 인터넷 기반 스트레스 회복 개입 FOREST: 무작위 통제 시험을 위한 연구 프로토콜Study Protocol Published on 2021-08-212022-09-10 Journal: Trials [Category] MERS, SARS, 임상, [키워드] affected Anxiety Care CBT complex conducted contribute Control COVID-19 COVID-19 pandemic Depression Detachment Effect Efficacy Follow-up forest HCWs healthcare Healthcare staff healthcare worker Healthcare workers Injury Internet-Based Intervention internet-based interventions Intervention Keeping Mental mental health mental healthcare Mindfulness-based Moral injury Nurses offered outcome parallel group Psychological well-being PTSD Randomized controlled trial RCT reduce Relaxation Sleep Stress Stress recovery Study protocol Support Trial registration [DOI] 10.1186/s13063-021-05512-1 PMC 바로가기 [Article Type] Study Protocol
Piece of the puzzle: Remdesivir disassembles the multimeric SARS-CoV-2 RNA-dependent RNA polymerase complex퍼즐 조각: Remdesivir는 다량체 SARS-CoV-2 RNA 의존성 RNA 중합효소 복합체를 분해합니다Article Published on 2021-06-012022-09-11 Journal: Cell biochemistry and biophysics [Category] SARS, 치료제, [키워드] Accelerated molecular dynamics simulation adenosine ATP binding complex computational simulations contribute Detachment disrupt domain domains finding flexible followed by global mortality higher affinity hosts Human mechanism molecular molecular dynamics Molecular dynamics simulation non-structural proteins Nsp7 NSP8 nucleotide PALM Perturbation piece RdRP Remdesivir Replication replicative reported RNA RNA-dependent RNA polymerase SARS-CoV-2 SARS-like coronavirus significantly Spread structure-based design subunit the SARS-CoV-2 underlie Viral RNA virus [DOI] 10.1007/s12013-021-00977-y PMC 바로가기 [Article Type] Article