High levels of soluble RAGE are associated with a greater risk of mortality in COVID-19 patients treated with dexamethasoneArticle Published on 2022-11-052022-11-15 Journal: Respiratory Research [Category] SARS, 바이오마커, [키워드] Admission association Biomarker Biomarkers Blood level Clinical management Control correlated covariates COVID-19 COVID-19 patient COVID-19 patients death Determination Dexamethasone died disease severity elevated Follow-up greater host inflammatory response IL-6 increased risk independent Infection Inflammation investigated Mortality NEWS2 Patient patient population patients patients treated Pearson positive positive individual predict prognostic RAGE receptor reduce risk SARS-CoV-2 score second wave significantly lower sRAGE. subject Teaching treated Treatment university [DOI] 10.1186/s12931-022-02220-5 PMC 바로가기
Comparison of commercial SARS-CoV-2 surrogate neutralization assays with a full virus endpoint dilution neutralization test in two different cohorts두 개의 다른 코호트에서 상용 SARS-CoV-2 대리 중화 분석과 전체 바이러스 종말점 희석 중화 테스트의 비교Article Published on 2022-09-012022-09-11 Journal: Journal of virological methods [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료제, [키워드] ACE2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antibody Antibody titers biosafety level Cohort cohorts convalescent Convalescent SARS-CoV-2-infected individuals COVID COVID vaccinated individuals Cutoff detect Determination Dilution Endpoint Full virus neutralization test glycoprotein gold gold standard indicate infected individuals Infection Interaction labor labor-intensive level 3 neutralization Neutralization assay neutralization test neutralization tests Neutralizing antibodies neutralizing antibody Neutralizing antibody titer neutralizing antibody titers Qualitative quantitative measurement RBD Receptor binding domain receptor protein Replication SARS-CoV-2 SARS-CoV-2-infected individual spike glycoprotein surrogate surrogate virus neutralization test sVNT the RBD vaccinated individuals Viral viral spike virus Virus neutralization virus neutralization test VNT [DOI] 10.1016/j.jviromet.2022.114569 PMC 바로가기 [Article Type] Article
The impact of COVID-19 lockdown on children with recurrent wheezing and asthma in SpainArticle Published on 2022-09-012022-11-15 Journal: Journal of paediatrics and child health [Category] COVID19(2023년), SARS, 진단, [키워드] age analysed anti-asthmatic agent Asthma asthmatic Care children coronavirus SARS-CoV-2 country COVID COVID-19 Determination drastic enrolled First wave Hospital admission IgG implementation Laboratory testing lockdown males measure modify MOST National no difference Older Patient positive questionnaire remained required respiratory disorders SARS-CoV-2 SARS-CoV-2 IgG significant increase Spain Spread tested Treatment underlying disease was performed wheezing [DOI] 10.1111/jpc.16068 PMC 바로가기
Determination of rSpike Protein by Specific Antibodies with Screen-Printed Carbon Electrode Modified by Electrodeposited Gold Nanostructures전착된 금 나노구조에 의해 변형된 스크린 인쇄된 탄소 전극이 있는 특정 항체에 의한 rSpike 단백질의 측정Article Published on 2022-08-032022-09-11 Journal: Biosensors [Category] SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 albumin antibodies antibody antigen–antibody complex applicability binding Blood bovine bovine serum albumin carbon changed coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cyclic voltammetry (CV) Determination differential pulse voltammetry (DPV) DPV electrochemical immunosensor electrochemical impedance spectroscopy (EIS) electrode electron transfer evaluated exhibit gold gold nanostructures (AuNS) heterogeneous Interaction L-cysteine limit limit of detection nanostructure nonspecific Patient Protein pulse quantification rate constant Research respiratory SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 virus self-assembled monolayer (SAM) serum serum albumin severe acute respiratory syndrome Coronavirus solution Specific specific antibodies specific antibody specificity spike Spike protein spike protein (Spike). Spike proteins surface area was performed was used were assessed [DOI] 10.3390/bios12080593 PMC 바로가기 [Article Type] Article
Serum SARS-CoV-2 Antigens for the Determination of COVID-19 SeverityCOVID-19 중증도 결정을 위한 혈청 SARS-CoV-2 항원Article Published on 2022-07-282022-09-11 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] Antigen antigenic Antigenic assay Chemiluminescent assay CLIA COVID-19 COVID-19 diagnosis Determination diagnostic disease severity evaluate false-negative false-negative results followed by help intensive care Kinetics likelihood ratio marker N antigen nasopharyngeal non-severe patient non-severe patients onset of symptoms Patient performed polymerase chain reaction polymerase chain reactions positive Prognosis prognosis test. progression provided reverse transcriptase risk RT-PCR RT-PCRs SARS-CoV-2 SARS-COV-2 infection sensitive serum severe and non-severe patients severe COVID-19 severe patients severity Simoa swabs the WHO threshold transcriptase Viremia was determined were measured WHO Clinical Progression Scale [DOI] 10.3390/v14081653 PMC 바로가기 [Article Type] Article
Small-Molecule Thioesters as SARS-CoV-2 Main Protease Inhibitors: Enzyme Inhibition, Structure-Activity Relationships, Antiviral Activity, and X-ray Structure DeterminationSARS-CoV-2 주요 프로테아제 억제제로서의 소분자 티오에스테르: 효소 억제, 구조-활성 관계, 항바이러스 활성 및 X선 구조 결정Article Published on 2022-07-142022-09-11 Journal: Journal of medicinal chemistry [Category] COVID19(2023년), SARS, 치료제, [키워드] 3CL pro activity antiviral activity beta-coronaviruses Calu Calu-3 catalytic cells Compound Coronaviral coronavirus covalent binding crystallization Cys145 Determination exhibited host cell in viral infections inhibited inhibition inhibitor inhibitors M pro MERS-CoV protease Replication residue SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 Mpro Structure synthesis thioester Toxicity Transcription treat viral replication X-ray [DOI] 10.1021/acs.jmedchem.2c00636 PMC 바로가기 [Article Type] Article
Clinical, laboratory data and inflammatory biomarkers at baseline as early discharge predictors in hospitalized SARS-CoV-2 infected patients입원한 SARS-CoV-2 감염 환자의 조기 퇴원 예측인자로 기준선에서의 임상, 실험실 데이터 및 염증성 바이오마커Article Published on 2022-07-142022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 바이오마커, [키워드] Admission AUC baseline Beta C-reactive protein category CD25 clinical collected Corticosteroid Corticosteroids cytokine Cytokines D-dimers dehydrogenase Determination discharge discharged Factor group help hospital Hospitalization Hospitalized hospitals identify IMPROVE independent Inflammatory Inflammatory biomarker interferon interleukin laboratory data laboratory parameter Lactate lactate dehydrogenase logistic regression models Macrophage Male sex Mild mild patient mild patients Negative predictive value neutrophil NLR not need NPV oxygen oxygen saturation Oxygen therapy Patient performed plasma plasma sample plasma samples Positive predictive value PPV predict Predictive Predictive value predictor pro-inflammatory cytokine pro-inflammatory cytokines Protein receptor Regression model SARS-CoV-2 infected patient SARS-COV-2 infection SARS-CoV-2 pandemic sensitivity severity Spanish specificity Transmission Treatment variable virus worsening [DOI] 10.1371/journal.pone.0269875 PMC 바로가기 [Article Type] Article
Detectable Duration of Viable SARS-CoV-2, Total and Subgenomic SARS-CoV-2 RNA in Noncritically Ill COVID-19 Patients: a Prospective Cohort Study중증이 아닌 COVID-19 환자에서 생존 가능한 SARS-CoV-2, 전체 및 서브게놈 SARS-CoV-2 RNA의 감지 가능한 기간: 전향적 코호트 연구Article Published on 2022-06-292022-09-11 Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 바이오마커, 치료기술, [키워드] 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis clearance collected coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Culture Determination determine diagnosed Duration Evidence Factor feasibility gold gold standard hazard ratio Ill Immunocompromised Immunocompromised patients infection control Infectivity interquartile range investigated Isolation Kinetics marker median time N gene Nasopharyngeal swab nasopharyngeal swabs negativity Patient Prospective prospective cohort receipt Reinfection respiratory reverse transcription PCR RNA RNA RT-PCR RT-PCR SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 sgRNA SARS-CoV-2 sgRNAs severe acute respiratory syndrome Coronavirus sgRNA sgRNAs steroid subgenomic RNA subgenomic RNAs surrogate markers time Total total RNA transcript Viable Viral viral culture viral infectivity Viral RNA viral shedding [DOI] 10.1128/spectrum.00503-22 PMC 바로가기 [Article Type] Article
Electrochemical Determination of Interaction between SARS-CoV-2 Spike Protein and Specific AntibodiesSARS-CoV-2 스파이크 단백질과 특정 항체 간의 상호작용에 대한 전기화학적 측정Article Published on 2022-06-172022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis antibody Antigen antigen-antibody complex condition confirmation coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cyclic voltammetry (CV) Determination Diagnosis diagnosis of COVID-19 Effectiveness electrochemical immunosensor electrochemical impedance spectroscopy (EIS) gold modifications observé polyclonal presence of antibody Proteins recombinant respiratory SAM SARS-CoV-2 SARS-CoV-2 coronavirus SARS-CoV-2 proteins SARS-CoV-2 spike protein self-assembled monolayer (SAM) serologic diagnosis serological Serological diagnosis severe acute respiratory syndrome Coronavirus Specific specific antibodies spike Spike protein Spike proteins spike proteins (rSpike). the SARS-CoV-2 vaccination was used [DOI] 10.3390/ijms23126768 PMC 바로가기 [Article Type] Article
Determination of IgG1 and IgG3 SARS-CoV-2 Spike Protein and Nucleocapsid Binding-Who Is Binding Who and Why?IgG1 및 IgG3 SARS-CoV-2 스파이크 단백질 및 뉴클레오캡시드 결합의 결정 - 누가 누구와 왜 결합합니까?Article Published on 2022-05-272022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), MERS, SARS, 진단, 치료법, [키워드] acute respiratory distress acute respiratory distress syndrome Analysis antibody ARDS bind binding characteristic complement convalescent convalescent patient convalescent plasma COVID-19 cytokine cytokine release demonstrated Determination Differential analysis examined flight Glycation glycosylation humoral immune response IgG IgG1 IgG3 Immunoglobulin implicated indicated infected with SARS-CoV-2 mass spectrometry molecular mechanism nucleocapsid nucleocapsids Pathogenesis plasma samples Predictive predictive profile predominant Protein protein G respiratory distress Respiratory distress syndrome SARS-CoV-2 SARS-COV-2 infection spectral analysis spike Spike protein Spike proteins stimulate syndrome the spike protein thought [DOI] 10.3390/ijms23116050 PMC 바로가기 [Article Type] Article