The SARS-CoV-2 helicase as a target for antiviral therapy: Identification of potential small molecule inhibitors by in silico modelling항바이러스 치료의 표적으로서의 SARS-CoV-2 헬리카제: in silico 모델링을 통한 잠재적인 소분자 억제제 식별Article Published on 2022-07-012022-09-11 Journal: Journal of molecular graphics & modelling [Category] COVID19(2023년), SARS, 변종, 진단, 치료제, [키워드] Acetylcysteine active site acute respiratory syndrome addition anti-inflammatory property Antiviral antiviral activity antiviral therapeutics antivirals binding free energy clavulanic acid Compound coronavirus coronavirus disease COVID-19 DHX9 DNA DNA2 expected Fatty acid fatty acids free energies Helicase Hepatitis hepatitis C highlighting identification identify in silico include inhibitor inhibitory activity initial lead leads Ligand MERS-CoV molecular dynamics Molecular dynamics simulation molecular dynamics simulations non-structural protein nsp13 nsp13. nucleoside performed reported Research respiratory SARS-CoV SARS-CoV-2 SARS-CoV-2 nsp13 selected sequence Severe acute respiratory syndrome small molecule inhibitor specific inhibitor specific inhibitors strain structural homology structural proteins Structure structures synthetic the SARS-CoV-2 utilised Vaccine variant was performed were used [DOI] 10.1016/j.jmgm.2022.108193 PMC 바로가기 [Article Type] Article
DExD/H-box helicase 9 intrinsically controls CD8 + T cell-mediated antiviral response through noncanonical mechanismsDExD/H-box 헬리카제 9는 비정규 메커니즘을 통해 본질적으로 CD8 + T 세포 매개 항바이러스 반응을 제어합니다Article Published on 2022-02-112022-09-11 Journal: Science Advances [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] activated Activation antiviral immunity antiviral response Apoptosis binding CD8 Control Coordinate COVID-19 patients DHX9 domain effector effector cell ERK event expression Helicase independent independent of intrinsically LCK mechanism nuclear Phosphorylation proliferation proliferative promote PROTECT regulate Regulatory required survival T cell T cells TCR Transcription viral clearance virus infection ZAP70 [DOI] 10.1126/sciadv.abk2691 PMC 바로가기 [Article Type] Article
RNA Helicase A/DHX9 Forms Unique Cytoplasmic Antiviral Granules That Restrict Oncolytic Myxoma Virus Replication in Human Cancer CellsArticle Published on 2021-05-052023-08-30 Journal: Journal of Virology [Category] E형 간염, [키워드] antiviral granules DHX9 human cancer cells myxoma virus oncolytic viruses poxvirus RNA helicase A Virus-host interactions [DOI] 10.1128/JVI.00151-21 PMC 바로가기
Host–Viral Interactions Revealed among Shared Transcriptomics Signatures of ARDS and Thrombosis: A Clue into COVID-19 PathogenesisOriginal Article Published on 2020-10-172022-10-29 Journal: TH Open: Companion Journal to Thrombosis and Haemostasis [Category] COVID-19, [키워드] Activation acute respiratory distress Anticoagulant ARDS Biotechnology Coagulation coagulation factor Combination conducted Convolution COVID-19 COVID-19 pathogenesis COVID-19 patients database dataset datasets DEGs DHX9 differentially expressed gene disease effect size endothelial damage enrichment analysis expression data Gene Expression Helicase highly pathogenic host–virus interaction implication IMPROVE Infection Inflammation KAT2B low molecular weight lung lysine management mechanism Meta-analysis NCBI-GEO network novel corona virus observation Pathway enrichment analysis Pathways Protein PSMB2 random effect RBX1 RELA Replication Revealed SARS-CoV-2 Sepsis shown signature subsequent subunit suggested syndrome Therapeutic strategies thrombosis thrombotic TP53 transcriptomics Treatment Venous Thromboembolism virus VTE was done was used were used worsened [DOI] 10.1055/s-0040-1721706 PMC 바로가기 [Article Type] Original Article
Hepatitis B virus X protein modulates upregulation of DHX9 to promote viral DNA replicationArticle Published on 2020-03-012023-06-11 Journal: Cellular microbiology [Category] B형 간염, [키워드] DHX9 HBx protein Hepatitis B virus Nup98 ubiquitylation. [DOI] 10.1111/cmi.13148 PMC 바로가기
DHX9 interacts with APOBEC3B and attenuates the anti-HBV effect of APOBEC3BArticle Published on 2020-02-142023-06-03 Journal: Emerging Microbes & Infections [Category] B형 간염, Fulltext, [키워드] APOBEC3B attenuate DHX9 Hepatitis B virus Interaction [DOI] 10.1080/22221751.2020.1725398 PMC 바로가기 [Article Type] Article
The biology of DHX9 and its potential as a therapeutic targetReview Published on 2016-07-052023-08-29 Journal: Oncotarget [Category] E형 간염, [키워드] DExD/H-box DHX9 Helicase Maleless RNA helicase A [DOI] 10.18632/oncotarget.8446 PMC 바로가기 [Article Type] Review