Potential anti-mpox virus activity of atovaquone, mefloquine, and molnupiravir, and their potential use as treatmentsArticle Published on 2023-03-092023-06-10 Journal: The Journal of Infectious Diseases [Category] 원숭이두창, [키워드] Antiviral atovaquone dihydroorotate dehydrogenase mefloquine molnupiravir mpox pan-Orthopoxvirus. [DOI] 10.1093/infdis/jiad058
Recent approaches in the drug research and development of novel antimalarial drugs with new targetsArticle Published on 2023-01-242024-08-27 Journal: Acta Pharmaceutica [Category] 말라리아, [키워드] Antimalarial drugs dihydroorotate dehydrogenase protein kinases.
DHODH and cancer: promising prospects to be exploredReview Published on 2021-05-102022-10-31 Journal: Cancer & Metabolism [Category] COVID-19, [키워드] association Cancer Cancer cells Cancer metabolism Cancer therapy de novo De novo pyrimidine biosynthesis DHODH DHODH inhibitors dihydroorotate dehydrogenase disease Effect enzyme Evidence Human inhibitor mechanism Mitochondria mitochondrial multiple sclerosis pathway rheumatoid arthritis therapeutic target Therapies Treatment Tumor tumor progression [DOI] 10.1186/s40170-021-00250-z PMC 바로가기 [Article Type] Review
Potential Anti-SARS-CoV-2 Therapeutics That Target the Post-Entry Stages of the Viral Life Cycle: A Comprehensive Review바이러스 수명 주기의 진입 후 단계를 대상으로 하는 잠재적인 Anti-SARS-CoV-2 치료제: 종합 검토Review Published on 2020-09-262022-09-10 Journal: Viruses [Category] SARS, 비임상, [키워드] (RdRp breath chemical structures clinical investigation clinical trial clinical trials clinically Comprehensive coronavirus coronavirus disease COVID-19 decrease described Dexamethasone dihydroorotate dehydrogenase early stage Effect effective EIDD-2801 facilitate Favipiravir Health care Health care system health care systems identify include Infection life life cycle limit M pro main protease mechanism molecular monoclonal antibodies mortality rate pandemic Papain-like protease pharmaceutical companies polypeptides Potential presenting Prevent protease RdRP Remdesivir Research review RNA-dependent RNA polymerase SARS-CoV-2 scientist severity of COVID-19 Small molecules Stage Structure target Therapeutics Treatment Viral viral infection viral life cycle Viral protein Viral proteins Viral RNA viral RNA-dependent RNA polymerase [DOI] 10.3390/v12101092 PMC 바로가기 [Article Type] Review
Design and tests of prospective property predictions for novel antimalarial 2-aminopropylaminoquinolones신규 항말라리아 2-아미노프로필아미노퀴놀론에 대한 잠재적 물성 예측의 설계 및 테스트Article Published on 2020-08-242024-08-26 Journal: Journal of Computer-Aided Molecular Design [Category] 말라리아, [키워드] ADME antimalarial dihydroorotate dehydrogenase drug design PBPK QSAR [DOI] 10.1007/s10822-020-00333-x PMC 바로가기 [Article Type] Article
Identification and mechanistic understanding of dihydroorotate dehydrogenase point mutations in Plasmodium falciparum that confer in vitro resistance to the clinical candidate DSM265플라스모디움 팔시파룸에서 임상 후보물질 DSM265에 대한 인비트로 저항성을 부여하는 디하이드로오로테이트 탈수소효소 점 돌연변이의 확인 및 기전적 이해Article Published on 2018-11-152024-08-26 Journal: ACS infectious diseases [Category] 말라리아, [키워드] dihydroorotate dehydrogenase drug resistance gene editing malaria Plasmodium [DOI] 10.1021/acsinfecdis.8b00211 PMC 바로가기 [Article Type] Article
A genome-wide siRNA screen identifies a druggable host pathway essential for the Ebola virus life cycleResearch Published on 2018-08-072023-08-30 Journal: Genome Medicine [Category] E형 간염, [키워드] Carbamoyl phosphate synthetase 2 aspartate transcarbamylase and dihydroorotase De novo pyrimidine synthesis dihydroorotate dehydrogenase Ebola virus Host factor NNSV Non-segmented negative-sense RNA viruses siRNA screen Teriflunomide [DOI] 10.1186/s13073-018-0570-1 PMC 바로가기 [Article Type] Research
Plasmodium falciparum dihydroorotate dehydrogenase: a drug target against malariaArticle Published on 2018-08-012024-08-28 Journal: Future Med Chem [Category] 말라리아, [키워드] antimalarial dihydroorotate dehydrogenase malaria PfDHODH Plasmodium falciparum
A Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitor with Improved Drug-like Properties for Treatment and Prevention of MalariaArticle Published on 2016-12-092024-08-27 Journal: ACS Infectious Diseases [Category] 말라리아, [키워드] dihydroorotate dehydrogenase malaria Plasmodium pyrimidine biosynthesis