dipeptidyl peptidase – Communicable Diseases Research

Plasma metabolome and cytokine profile reveal glycylproline modulating antibody fading in convalescent COVID-19 patients

혈장 대사체 및 사이토카인 프로필은 회복기 COVID-19 환자에서 글리실프롤린 조절 항체 퇴색을 나타냅니다

Article

Published on 2022-08-232022-09-11
Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 바이오마커, 진단,

Coronavirus disease 2019 and the placenta: A literature review

코로나바이러스 질병 2019 및 태반: 문헌 검토

Review

Published on 2022-08-012022-09-11
Journal: Placenta [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료기술,

[키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme-2 Antigen Basigin canonical cathepsin B Cathepsin B/L caused CD147 CD26 Chain Reaction Clinical pathology coding coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 CTL dipeptidyl peptidase Dipeptidyl peptidase-4 DPP4 electron microscopy eligible enzyme evaluate Express expressed Factor fetal furin IFITM1 immunohistochemistry implicated In situ hybridization interferon involved literature review Localization LY6E lymphocyte mechanism Microscopy multiple organ multiple organs nonspecific organ systems Particle Particles Pathogenesis pathogenesis of SARS-CoV-2 pathology permissiveness Placenta placental Placental infection placental pathology polymerase chain polymerase chain reaction Pregnancy pregnancy trimesters profile Proteases Protein Proteins receptor reduce RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptors Serine severe acute respiratory syndrome Coronavirus single-cell analysis the disease TMPRSS2 transmembrane transmembrane protein transmembrane serine protease Vascular viral pathogenesis Viral RNA virus
[DOI] 10.1016/j.placenta.2022.07.007 PMC 바로가기 [Article Type] Review

Predictive medicinal metabolites from Momordica dioica against comorbidity related proteins of SARS-CoV-2 infections

SARS-CoV-2 감염의 동반 질환 관련 단백질에 대한 Momordica dioica의 예측 의약 대사 산물

Article

Published on 2022-07-012022-09-11
Journal: Journal of biomolecular structure & dynamics [Category] COVID19(2023년), SARS, 치료제,

[키워드] ACE-2 ADME angiotensin angiotensin converting enzyme antidiabetic Antiviral binding binding affinities Blood brain barrier cardiovascular disease catechin comorbid comorbid condition comorbid conditions Comorbidity Compound correlated DDP4 diabetes dipeptidyl peptidase docking score DPP4 drugs enzyme exhibited Favipiravir flavonoid flavonoids gastrointestinal tract hederagenin Human Hydroxychloroquine immune immunomodulatory activities in silico in vitro investigated involved kidney ligands metabolite molecular molecular docking Momordica Momordica dioica oleanolic acid plant predicted protease Proteases Protein quercetin RdRP receptor reflect Remdesivir reported RNA-dependent RNA polymerase Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 main protease significant interaction Spike protein the SARS-CoV-2 therapeutic viral entry viral proteases
[DOI] 10.1080/07391102.2020.1868340 PMC 바로가기 [Article Type] Article

Proline-specific peptidase activities (DPP4, PRCP, FAP and PREP) in plasma of hospitalized COVID-19 patients

입원한 COVID-19 환자의 혈장에서 프롤린 특이적 펩티다제 활성(DPP4, PRCP, FAP 및 PREP)

Article

Published on 2022-06-012022-09-11
Journal: Clinica chimica acta; international journal of cli [Category] MERS, 바이오마커, 진단,

[키워드] Activation activities activity Alpha Biomarker changes in collected coronavirus COVID-19 COVID-19 patient COVID-19 patients decrease dipeptidyl peptidase Dipeptidyl peptidase 4 discharge DPP4 dysregulated dysregulation elevated FAP feature fibroblast Fibroblast activation protein alpha Follow-up healthy control healthy controls Hospital admission Hospital stay Hospitalization hospitalized COVID-19 patient hospitalized COVID-19 patients immune system investigated pathophysiological patients peptidase plasma PRCP PrEP proline Prolyl oligopeptidase Prolylcarboxypeptidase. Protein remained Sepsis Septic shock significantly significantly increased significantly lower utility were measured while
[DOI] 10.1016/j.cca.2022.03.005 PMC 바로가기 [Article Type] Article

The Association Between Antidiabetic Agents and Clinical Outcomes of COVID-19 Patients With Diabetes: A Bayesian Network Meta-Analysis

항 당뇨병 제와 당뇨병 환자의 COVID-19 환자의 임상 결과 사이의 연관성 : 베이지안 네트워크 메타 분석

Meta-Analysis

Published on 2022-05-272022-08-31
Journal: Frontiers in Endocrinology [Category] meta-analysis,

[키워드] (Metformin agent agonist analyzed antidiabetic antidiabetic agents association Bayesian Bayesian network meta-analysis clinical Cochrane Library COVID-19 COVID-19 mortality database death diabete diabetes dipeptidyl peptidase Dipeptidyl peptidase-4 FIVE followed by glucagon-like peptide Glucagon-like peptide-1 Glucose highest inception increased mortality individual inhibitor insulin insulin treatment metformin Mortality network Network meta-analysis Odds ratio pairwise meta-analysis Probability PROSPERO protective effect receptor reduced risk searched Seven severe disease significantly sodium sulfonylurea Treatment Web of Science
[DOI] 10.3389/fendo.2022.895458 PMC 바로가기 [Article Type] Meta-Analysis

Impact of natural selection on global patterns of genetic variation and association with clinical phenotypes at genes involved in SARS-CoV-2 infection

SARS-CoV-2 감염과 관련된 유전자의 유전적 변이 및 임상 표현형과의 연관성에 대한 자연 선택의 영향

Article

Published on 2022-05-242022-09-11
Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), SARS, 변종,

[키워드] 1000 Genomes Project ACE2 ACE2 expression acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive African African diversity Amino acid amino acid change analyzed angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 Antigen association caused clinical phenotype clinical phenotypes complex coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 dipeptidyl peptidase Dipeptidyl peptidase 4 DPP4 Electronic health record Electronic health records enzyme European Genetic genetic diversity genetic variants Genetic variation Genome genomic Haplotype haplotypes Health host gene host genes Human identify Impact in some individual investigated involved Lineage locus LY6E lymphocyte minor allele frequency natural selection nonsynonymous variant pandemic patients with COVID-19 phenotype phenotype association. populations Positive selection protease Protein provide regulatory region SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2/COVID-19 Serine serine 2 severe acute respiratory syndrome Coronavirus target targets TMPRSS2 transmembrane transmembrane protease serine 2 variant Variation viral infections viruses
[DOI] 10.1073/pnas.2123000119 PMC 바로가기 [Article Type] Article

Two Different Therapeutic Approaches for SARS-CoV-2 in hiPSCs-Derived Lung Organoids

hiPSC에서 파생된 폐 오르가노이드에서 SARS-CoV-2에 대한 두 가지 다른 치료 접근 방식

Article

Published on 2022-04-052022-09-11
Journal: Cells [Category] COVID19(2023년), SARS, 바이오마커, 변종,

[키워드] ACE2 airways alveolar approach approaches AT2 candidate Cell complex COVID-19 COVID-19 treatment develop dipeptidyl peptidase Dipeptidyl peptidase-4 distal DPP4 drugs Efficacy Efficiency evaluate Evidence Express expression of gene health emergency hiPSCs hLORGs homologous host cells human cells implicated in vitro in vivo Infection Inflammatory response Innate immunity lung modulation monoclonal Neutralizing neutralizing antibody neutralizing monoclonal antibody organ Organoid peptide pluripotent stem cell Protein proximal pseudovirus receptor receptors reducing reduction SARS-CoV-2 SARS-CoV-2 S SARS-CoV2 SARS-CoV2 pseudovirus spike Spike protein stem cells Structure synthetic peptide tested tetravalent therapeutic These data treated Treatment variant Viral viral entry were infected
[DOI] 10.3390/cells11071235 PMC 바로가기 [Article Type] Article

Molecular phylogeny of coronaviruses and host receptors among domestic and close-contact animals reveals subgenome-level conservation, crossover, and divergence

국내 및 밀접 접촉 동물 사이의 코로나바이러스 및 숙주 수용체의 분자 계통 발생은 하위 게놈 수준의 보존, 교차 및 분기를 나타냅니다

Article

Published on 2022-04-012022-09-11
Journal: BMC veterinary research [Category] COVID19(2023년), SARS, 치료법,

[키워드] ACE2 ACE2 residue acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 alphacoronavirus alphacoronaviruses aminopeptidase N analyzed angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 animals APN binding cathepsin L cattle Comparative Comparative phylogeny Complete conservation conserved Consistency coronavirus Coronavirus-2 Coronaviruses Critical cross determine dipeptidyl peptidase Dipeptidyl peptidase 4 DPP4 enzyme Enzymes events explain Factor furin furin cleavage furin cleavage motif genome sequence Genome sequences Host host receptor Host receptors hosts identify infecting intermediate host Intersection membrane MERS MERS-CoV Middle East Middle East respiratory syndrome Coronavirus molecular N protein N proteins nucleocapsid offer other coronavirus other coronaviruses Phylogenetic tree phylogenies Phylogeny polybasic Protein Protein binding Proteins receptor receptors Recombination respiratory syndrome coronavirus retained reveal S proteins S, E, M, and N proteins SARS-CoV SARS-CoV-2 SARS-CoV-2 spike protein SAS segregation sequence Serine Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 sialic acid similarities similarity spike Spike protein Support the S protein theory TMPRSS2 transmembrane serine protease transmembrane serine protease 2 unique Viral protein Viral proteins virus white-tailed deer β-coronavirus
[DOI] 10.1186/s12917-022-03217-4 PMC 바로가기 [Article Type] Article

Cathepsin B is a potential therapeutic target for coronavirus disease 2019 patients with lung adenocarcinoma

카텝신 B는 폐 선암종을 가진 코로나바이러스 질병 2019 환자를 위한 잠재적인 치료 표적입니다

Article

Published on 2022-02-012022-09-11
Journal: Chemico-biological interactions [Category] 바이오마커,

[키워드] angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Atla available data Basigin bioinformatics cancers cathepsin cathepsin B cause Cell coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients CTSB database determine diagnosed with COVID-19 dipeptidyl peptidase Dipeptidyl peptidase 4 drug therapy explain expressed expression Gene Expression Omnibus GEO global public health Hyperinflammatory Hyperinflammatory response identify Immune cell infiltration implicated lung adenocarcinoma lung cancer lung cancer patient lung cancer patients mortality rate outcome Patient patients patients with COVID-19 positively correlated potential therapeutic target presenting Proinflammatory cytokine SARS-CoV-2 SARS-COV-2 infection severe COVID-19 susceptibility the SARS-CoV-2 therapeutic target therapy for COVID-19 tissue upregulation
[DOI] 10.1016/j.cbi.2022.109796 PMC 바로가기 [Article Type] Article

Glucose-lowering drugs and outcome from COVID-19 among patients with type 2 diabetes mellitus: a population-wide analysis in Hong Kong

제 2 형 당뇨병 환자의 포도당 저하 약물 및 Covid-19의 결과 : 홍콩의 인구 전체 분석

Article

Published on 2021-10-202022-08-31
Journal: BMJ Open [Category] MERS, SARS, 치료제,

[키워드] 95% CI adjusted Admission adverse outcome age Analysis association baseline Clinical outcome Cohort Comorbidities Comorbidity Composite composite endpoint confirmed case confirmed cases COVID-19 Cox regression diabete diabetes diabetes & dipeptidyl peptidase Dipeptidyl peptidase-4 drug drugs endocrinology endocrinology. Endpoint Glucose Glucose-lowering drug Haemoglobin hazard health facilities Hong Kong In-hospital death incidence inhibitor inhibitors insulin intensive care intensive care unit admission Invasive mechanical ventilation median age men metformin multivariate multivariate Cox regression outcome Patient patients with diabete predict public health reduced retrospective cohort secondary outcome Sex smoking treated type 2 diabete type 2 diabetes user worse prognosis
[DOI] 10.1136/bmjopen-2021-052310 PMC 바로가기 [Article Type] Article