Intranasal administration of BReC-CoV-2 COVID-19 vaccine protects K18-hACE2 mice against lethal SARS-CoV-2 challenge Research Published on 2022-03-142022-10-05 Journal: NPJ Vaccines [Category] 임상, [키워드] Administered administration Antigen approved boost cause Chemistry COVID-19 COVID-19 vaccine delta variant diphtheria toxoid dose global pandemic immune response induce intramuscular K18-hACE2 mice lung mice muscular nasal neutralizing antibody pathogen PROTECT protection provided RBD RBD IgA respiratory tissue responsible robust SARS-CoV-2 serum the disease upper respiratory tract vaccination Vaccine viral respiratory Viral RNA Washington WHO [DOI] 10.1038/s41541-022-00451-7 [Article Type] Research
DrugWAS: Drug-wide Association Studies for COVID-19 Drug RepurposingDrugWAS: COVID-19 약물 용도 변경에 대한 약물 전반의 협회 연구Article Published on 2021-12-012022-09-11 Journal: Clinical Pharmacology and Therapeutics [Category] MERS, 신약개발, [키워드] 95% CI 95% confidence interval Admission Analysis applied association azelastine center clinical trials cohort study coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 diagnosis COVID-19 disease COVID-19 severity death Dextromethorphan diphtheria toxoid drug drugs Efficacy EHR EHR data Electronic health record estradiol ethinyl estradiol exposure to fatty acids Flaxseed fluticasone Health health record ibuprofen identify IMPROVE intensive care intensive care unit list lower risk mechanical ventilation multivariable logistic regression Odds ratio omega-3 Omega-3 fatty acids outcomes overlap pandemic patients with COVID-19 performed pertussis vaccine pneumococcal polysaccharide vaccine Potential treatment Primary outcome Propensity score pseudoephedrine randomized clinical trial repurposing retrospective cohort risk of death secondary Secondary analyses Secondary outcomes significantly tetanus toxoid ubidecarenone university Vaccine Vaccines was selected Weighting [DOI] 10.1002/cpt.2376 PMC 바로가기 [Article Type] Article
Antibody Kinetics and Response to Routine Vaccinations in Infants Born to Women Who Received an Investigational Trivalent Group B Streptococcus Polysaccharide CRM 197 -Conjugate Vaccine During Pregnancy조사 3가 그룹 B 연쇄상구균 다당류 CRM 197 -임신 중 접합 백신을 받은 여성에게서 태어난 영아의 항체 동역학 및 정기 예방 접종에 대한 반응Articles and Commentaries Published on 2017-12-012022-09-06 Journal: Clinical Infectious Diseases: An Official Publicat [Category] Communicable Disease, 백일해, 파상풍, [키워드] age antenatal vaccination antibody antibody level antibody levels Birth capsular clinical clinically Combination detectable Diphtheria diphtheria toxoid disease dosage dosages dose during pregnancy elicited enrolled geometric mean geometric mean concentration group group B Streptococcus conjugate vaccine groups Haemophilus influenzae Haemophilus influenzae type b immune response immune responses Infant Infants invasive investigated Kinetics Maternal mother not affect pediatric Placebo placebo group pneumococcal pneumococcal vaccination Pregnancy Randomized receive Received recipients Registration response Result routine routine immunization serotype serotype-specific serotypes significantly higher single-center study Streptococcus Tetanus the placebo group timepoint transferred trivalent vaccination Vaccine were assessed women [DOI] 10.1093/cid/cix666 PMC 바로가기 [Article Type] Articles and Commentaries
Polysaccharide conjugate vaccine protein carriers as a “neglected valency” – Potential and limitations다당체 접합 백신 단백질 운반체로서의 "무시된 배가성" - 잠재력과 한계Article Published on 2017-06-052024-08-18 Journal: Vaccine [Category] 백일해, 파상풍, [키워드] diphtheria toxoid Neglected valency Polysaccharide conjugate vaccines Protein carriers Protein D of non-typeable Haemophilus influenzae tetanus toxoid [DOI] 10.1016/j.vaccine.2017.04.078
Potential protective immunogenicity of tetanus toxoid, diphtheria toxoid and Cross Reacting Material 197 (CRM197) when used as carrier proteins in glycoconjugates당접합체에서 담체 단백질로 사용되는 경우 파상풍 톡소이드, 디프테리아 톡소이드 및 교차 반응 물질 197(CRM197)의 잠재적인 보호 면역원성journal-article Published on 2016-03-032024-07-30 Journal: Human vaccines & immunotherapeutics [Category] 파상풍, [키워드] carrier proteins Combination vaccines Cross Reacting Material 197 diphtheria toxoid Glycoconjugates protective immunity tetanus toxoid [DOI] 10.1080/21645515.2015.1086048 [Article Type] journal-article
Poor memory B cell generation contributes to non-protective responses to DTaP vaccine antigens in otitis-prone children불량한 기억 B 세포 생성은 중이염에 걸리기 쉬운 어린이의 DTaP 백신 항원에 대한 비보호 반응에 기여합니다journal-article Published on 2015-11-022024-07-30 Journal: Clinical and Experimental Immunology [Category] 백일해, 파상풍, [키워드] acute otitis media diphtheria toxoid memory B cells pertussis toxoid tetanus toxoid [DOI] 10.1111/cei.12660 [Article Type] journal-article
Synthesis and immunogenicity evaluation ofSalmonella entericaserovar Paratyphi A O-specific polysaccharide conjugated to diphtheria toxoid살모넬라 엔테리카 세로바르 파라티피 A O-특이 다당류와 디프테리아 독소의 접합체 합성 및 면역원성 평가journal-article Published on 2014-06-042024-07-31 Journal: Human vaccines & immunotherapeutics [Category] 살모넬라증, [키워드] Conjugate vaccine diphtheria toxoid paratyphoid polysaccharide antigen. S.Paratyphi A [DOI] 10.4161/hv.28130 [Article Type] journal-article
Comparison of CRM197, diphtheria toxoid and tetanus toxoid as protein carriers for meningococcal glycoconjugate vaccinesCRM197, 디프테리아 독소 및 파상풍 독소를 단백질 운반체로 사용한 수막염 당단백질 결합 백신의 비교journal-article Published on 2013-10-012024-07-30 Journal: Vaccine [Category] 파상풍, [키워드] Carrier priming Conjugate vaccines CRM(197) diphtheria toxoid meningococcal vaccines tetanus toxoid [DOI] 10.1016/j.vaccine.2013.07.078 [Article Type] journal-article