Lung disease network reveals impact of comorbidity on SARS-CoV-2 infection and opportunities of drug repurposing폐 질환 네트워크는 SARS-COV-2 감염에 대한 동반 질환의 영향과 약물 용도의 기회를 보여줍니다.Research Article Published on 2021-09-172022-08-31 Journal: BMC Medical Genomics [Category] SARS, 신약개발, 치료기술, 치료제, [키워드] accelerate Algorithm Analysis approach association biological processes build Care clinical condition clinical conditions clinical evidence Community Comorbidity COVID-19 COVID-19 patient COVID-19 patients disease Disease network disorder drug Drug development functional functional protein genetic association Health Health care Health care system identify IMPROVE Lung disease Lung diseases lung disorder lung disorders Lungs molecular basis molecular feature Mortality overlap overlapped overlapping Pathway enrichment analysis Patient possession Protein Protein–protein interaction reason for respiratory Respiratory disease respiratory diseases Result reveal SARS-CoV-2 SARS-COV-2 infection similarity supplementary material target targets virus was used with COVID-19 [DOI] 10.1186/s12920-021-01079-7 PMC 바로가기 [Article Type] Research Article
Mathematical model of the feedback between global supply chain disruption and COVID-19 dynamicsArticle Published on 2021-07-292022-10-29 Journal: Scientific Reports [Category] COVID-19, SARS, [키워드] activities alleviate Care Containment strategy COVID-19 Critical Disease network Effect exacerbated Government Health Health care economics highlight Infection Infectious disease Infectious diseases information technology Interaction mathematical mathematical model North America outbreak pandemic pandemic of COVID-19 Pandemics provide reduce resource SARS-CoV-2 Scientific data spatiotemporal Spread the disease threat Travel viral infection [DOI] 10.1038/s41598-021-94619-1 PMC 바로가기 [Article Type] Article
The mechanism and active compounds of semen armeniacae amarum treating coronavirus disease 2019 based on network pharmacology and molecular dockingOriginal Article Published on 2021-02-042022-10-31 Journal: Food & Nutrition Research [Category] COVID-19, [키워드] 3CLpro ACE2 amygdalin AutoDock binding activity biological processes caspase-3 cellular component Chinese Clinical practice collected component Compound coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 Cytoscape database DAVID disease Disease network dissemination docking Effect EGFR eight endothelial enrichment analysis enzyme II epidermal GeneCards growth factor HRAS IL6 immunofluorescence indicated Inflammatory Injury Interaction KEGG Kyoto lung Lung inflammation MAPK MAPK1 MAPK3 mechanism mice modulating molecular docking molecular functions molecular mechanism network analysis network pharmacology nine objective OMIM Ontology outbreak pathway Pathways PPI Prevent protease Protein PubChem database public health receptor regulated Result retrieved SARS-CoV-2 Semen semen armeniacae amarum significantly increased SRC suggested target target prediction TCM TCMSP threat Transcription treated treating COVID-19 Treatment TTD Vascular VEGF VEGFA virus was used Western blot analysis [DOI] 10.29219/fnr.v65.5623 PMC 바로가기 [Article Type] Original Article
CovMulNet19, Integrating Proteins, Diseases, Drugs, and Symptoms: A Network Medicine Approach to COVID-19Original Research: COVID-19 Research in Network and Systems Medicine Published on 2020-11-172022-10-30 Journal: Network and Systems Medicine [Category] COVID-19, [키워드] Analysis approach bootstrap Comorbidities Comorbidity Complex networks Compound condition conditions COVID-19 COVID-19 patients disease Disease network drug Extensive Factors human proteins Inclusion Interaction interactome intestinal material Medicine molecular molecular interaction multidimensional network network analysis Neurological disease pathology patients Proteins randomization Randomized reported representing risk factor SARS-CoV-2 proteins similarity Symptom Symptoms the disease treat [DOI] 10.1089/nsm.2020.0011 PMC 바로가기 [Article Type] Original Research: COVID-19 Research in Network and Systems Medicine