Sugar-coated bullets: Unveiling the enigmatic mystery ‘sweet arsenal’ in osteoarthritisReview Article Published on 2024-03-112024-09-05 Journal: Heliyon [Category] update2024, [키워드] disease pathogenesis Glycation glycosylation Osteoarthritis Protein modification [DOI] 10.1016/j.heliyon.2024.e27624 PMC 바로가기 [Article Type] Review Article
Cell Type-Specific Extracellular Vesicles and Their Impact on Health and DiseaseReview Published on 2024-02-272024-09-05 Journal: International Journal of Molecular Sciences [Category] update2024, [키워드] cell type-specific extracellular vesicles Diagnostic biomarkers disease pathogenesis Exosomes Extracellular vesicles Intercellular communication [DOI] 10.3390/ijms25052730 PMC 바로가기 [Article Type] Review
Upregulation of interleukin-19 in saliva of patients with COVID-19Article Published on 2022-09-262022-11-15 Journal: Scientific Reports [Category] SARS, 바이오마커, [키워드] adjusted Admission adult COVID-19 patients Analysis asymptomatic patient Autopsy Blood C-reactive protein Comorbidity Concentration Corticosteroid COVID-19 COVID-19 disease COVID-19 pathogenesis COVID-19 patients D-dimer dataset death demographics Diabetes Mellitus disease pathogenesis disease severity expression level ferritin healthy control Hospital stay Inflammation interferon beta lung lung cells marker mechanical ventilation nasopharyngeal swabs Patient patients with COVID-19 plasma protein level receptor Saliva SARS-CoV-2 SARS-COV-2 infection serum severity significantly higher Tocilizumab transcriptomic upregulated with COVID-19 [DOI] 10.1038/s41598-022-20087-w PMC 바로가기
Longitudinal profiles of plasma gelsolin, cytokines and antibody expression predict COVID-19 severity and hospitalization outcomesArticle Published on 2022-09-062022-11-15 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, 변종, 진단, [키워드] actin-binding protein Analysis anti-Spike IgG antibody blood sample Clinical management clinical parameter collected Combination Control correlated COVID-19 COVID-19 disease COVID-19 hospitalization COVID-19 negative COVID-19 patient COVID-19 severity CRP CRP-C-reactive protein cytokine death develop disease disease pathogenesis expression ferritin Gelsolin greater health system healthy individuals Hospitalization hospitalized COVID-19 patient IgG IL-6 IMPROVE innate immune Intervention involved IP-10 Laboratory longitudinal M-CSF marker outcome outcomes plasma platform predict profile prognostic Prognostic marker reduced Research SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein SEM significantly utility viral infections while [DOI] 10.3389/fimmu.2022.1011084 PMC 바로가기
SARS-CoV-2 productively infects primary human immune system cells in vitro and in COVID-19 patientsSARS-CoV-2는 시험관 내 및 COVID-19 환자에서 1차 인간 면역계 세포를 생산적으로 감염시킵니다Article Published on 2022-08-172022-09-11 Journal: Journal of Molecular Cell Biology [Category] SARS, 진단, 치료기술, 치료법, [키워드] accumulating acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Apoptosis appear B and T lymphocytes B cells B lymphocyte B lymphocytes CD4+ T lymphocyte Cell circulating leukocytes coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Cytokine storm disease pathogenesis disease severity double-stranded RNA expressive flow cytometry hallmark Host Human immune system hyperinflammatory state Immune cell immune cells immune dysfunction immunofluorescence analysis implication in vitro indicated infect Infection inflammatory state leukocyte leukocytes lung tissue Lymphocytes lymphocytopenia monocyte Monocytes mononuclear cell mononuclear cells outcome patients PBMC Peripheral blood Peripheral blood mononuclear cell (PBMC) Peripheral blood mononuclear cells Prognosis progression Replication respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infection in vitro severe acute respiratory syndrome Coronavirus susceptible sustained symptom onset T cell T lymphocytes Viral viral replication Viral RNA virus spread [DOI] 10.1093/jmcb/mjac021 PMC 바로가기 [Article Type] Article
Differential gene expression profiling reveals potential biomarkers and pharmacological compounds against SARS-CoV-2: Insights from machine learning and bioinformatics approachesArticle Published on 2022-08-172022-11-15 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, 치료기술, 치료제, [키워드] acid approach bioinformatics caused Comorbidities complex interplay Compound contribute coronavirus 2 COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients COVID-19 progression Critical cyclosporine DEGs detect develop differentially expressed gene disease disease pathogenesis dysregulated E2F1 effort EGR1 expressed Factor functional functional enrichment Gene expression profiling Gene regulatory networks Genetic Genomics healthy controls healthy individual humans identify indicated individual individuals insight inter-individual Interaction machine learning approach MAX Mental mental retardation miRNA expression miRNAs nasopharyngeal network analysis offer Ontology overexpressed pandemic pathophysiology pathway pharmacological Potential biomarker Regulatory respiratory responsible reveal RNA-Seq RNA-seq data SARS-CoV-2 SARS-COV-2 infection Spread SRF TFS the SARS-CoV-2 therapeutic option therapeutic target therapeutic targets Vaccine Variability with COVID-19 YY1 [DOI] 10.3389/fimmu.2022.918692 PMC 바로가기
A Multiscale Model of COVID-19 DynamicsCOVID-19 역학의 다중 스케일 모델Article Published on 2022-08-092022-09-11 Journal: Bulletin of Mathematical Biology [Category] SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis Antiviral treatment Between-host dynamics can not caused Characteristics coronavirus coupling COVID-19 develop disease disease pathogenesis Dynamics epidemiological epidemiological data facilitate global pandemic hand hygiene highlight Host hygiene implementation include infected individual infected individuals Infection Infectious disease Infectious diseases Intervention Local Masks measure Model multiscale model other infectious diseases Outbreaks pathogen Pathogenesis Pathogens Prevent progression provide public health reservoir SARS-CoV-2 severe acute respiratory syndrome Coronavirus social distancing Spread the disease Transmission transmission route Treatment viral infection Virological wearing mask within-host dynamics [DOI] 10.1007/s11538-022-01058-8 PMC 바로가기 [Article Type] Article
Multiplex protein profiling of bronchial aspirates reveals disease-, mortality- and respiratory sequelae-associated signatures in critically ill patients with ARDS secondary to SARS-CoV-2 infection기관지 흡인물의 다중 단백질 프로파일링은 SARS-CoV-2 감염에 이차적으로 ARDS가 있는 중환자에서 질병, 사망률 및 호흡기 후유증과 관련된 징후를 나타냅니다.Multicenter Study Published on 2022-07-292022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, 치료기술, [키워드] acute respiratory distress acute respiratory distress syndrome adverse outcomes AGR2 all-cause mortality ARDS association BAS bronchial bronchial aspirate confounding factors correlated COVID-19 COVID-19 patients Cox regression model Cox regression models Critically ill Critically ill patient critically ill patients CST5 Decision making determinant disease pathogenesis DPP7 ENTPD2 expressed Factor FCRL1 highest hospital discharge host response ICU ICU – intensive care unit identify IL-1α immune IMV intensive care Invasive mechanical ventilation Kaplan-Meier curve Kaplan-Meier curves KYAT1 lung cells Lung function mechanism molecular Mortality mortality risk multicenter study NADK Non-COVID-19 Non-COVID-19 patients nonsurvivor nonsurvivors NQO2 NTF4 OSM outcomes Pathogenesis pathology Poor Protein proteomic proteomics proximity extension assay PTN quantified radiological feature radiological features random Random forest reduced respiratory respiratory distress Respiratory distress syndrome reveal risk Risk assessment SARS-COV-2 infection SRPK2 subgroup subgroups supported Survivors the disease the strongest THOP1 TRAIL TSS TYMP Viral viral infectivity were used with COVID-19 [DOI] 10.3389/fimmu.2022.942443 PMC 바로가기 [Article Type] Multicenter Study
Proteomic Profile of Procoagulant Extracellular Vesicles Reflects Complement System Activation and Platelet Hyperreactivity of Patients with Severe COVID-19응고촉진 세포외 소포의 단백질 프로파일은 중증 COVID-19 환자의 보체 시스템 활성화 및 혈소판 과민반응을 반영합니다Article Published on 2022-07-222022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acute inflammatory response alteration analyzed applied approach biological processe biological processes Biomarker Biomarkers cascades caused change changes in circulating Coagulation complement complement factors computational analysis COVID-19 COVID-19 patients Cytometry degranulation disease pathogenesis Diseases EVs experiment expressed extracellular vesicle Extracellular vesicles Flow flow cytometry group healthy donor healthy donors identify increase in indicated infected with SARS-CoV-2 LC-MS LC-MS/MS molecular pathophysiological Patient plasma Platelet Platelets procoagulant procoagulant activity profile progression Protein proteome proteomic SARS-CoV-2 SEC severe COVID-19 severe COVID-19 patients severity of COVID-19 significant changes in size exclusion chromatography System the disease tissue Tissue Factor total protein Vesicle was performed [DOI] 10.3389/fcimb.2022.926352 PMC 바로가기 [Article Type] Article
Targeting TFH cells in human diseases and vaccination: rationale and practice Reviews Published on 2022-07-112022-10-05 Journal: Nature Immunology [Category] 바이오마커, 유전자 메커니즘, [키워드] allergens antibody antibody affinity Antigen approach Autoantigens B cell B cells boost CD4+ T cell Cell cytokine disease disease pathogenesis Efficacy facilitate human disease Humoral immunity Infection knowledge lymphomagenesis maturation mechanisms memory pathogen clearance pathogenic protective antibody response receptor regulate Regulation reservoirs response Support survival T cell targeting TCR therapy Vaccine [DOI] 10.1038/s41590-022-01253-8 [Article Type] Reviews