Antigenic mapping reveals sites of vulnerability on α-HCoV spike proteinArticle Published on 2022-11-042022-11-15 Journal: Communications Biology [Category] SARS, 진단, [키워드] antigenic appear characterized conserved distal domain dominant effective epitope Epitopes feasibility HCoV-229E HCoV-NL63 highlight human coronavirus imperative N-terminal domain Neutralizing neutralizing antibody panel of antibody Protein RBD Receptor binding domain receptor binding site recognize representing reveal S protein S proteins similarity spike Spike protein subset the SARS-CoV-2 understanding Vaccine design Vaccine development [DOI] 10.1038/s42003-022-04160-8 PMC 바로가기
Cytotoxic lesions of the corpus callosum after COVID-19 vaccinationArticle Published on 2022-10-012022-11-15 Journal: Neuroradiology [Category] COVID19(2023년), SARS, 진단, [키워드] amnesia Antibody test Biochemistry blood cell count Brain callosum cerebrospinal fluid Coronavirus disease 2019 corpus COVID-19 COVID-19 mRNA Vaccination COVID-19 mRNA vaccine COVID-19 vaccination cytotoxic Cytotoxic lesions of the corpus callosum Depression disease distal Fever headache healthy intensity intravenous methylprednisolone inversion lesion limbs Mild encephalitis/encephalopathy with reversible splenial lesion. MRI mRNA nausea neurological Neurological symptom Patient PCR test reported SARS-CoV-2 splenial Symptom visual disturbance [DOI] 10.1007/s00234-022-03010-y PMC 바로가기
Single-cell transcriptomics reveals common epithelial response patterns in human acute kidney injuryArticle Published on 2022-09-092022-11-15 Journal: Genome Medicine [Category] 유전자 메커니즘, 진단, [키워드] Acute kidney injury adverse outcomes affected AKI Cell cell type changes in characterized Control COVID-19 criteria Critical Critical illness Critically ill patient diagnosed with COVID-19 disease disease-associated distal epithelial Gene Expression heterogeneity highlighting histology human kidney humans hypoxia Improving individual Injury inter-individual interferon response KDIGO kidney Kidney injury kidney tissue limbs mechanism molecular molecular responses occur oxidative stress performed Post-mortem provide proximal resource respiratory infections response reveal Sequencing single-cell sequencing. Single-cell transcriptomics subtype Therapies Transcriptome transcriptomic transcriptomics [DOI] 10.1186/s13073-022-01108-9 PMC 바로가기
A jejunal gastrointestinal stromal tumor with massive gastrointestinal hemorrhage treated by emergency surgery: A case reportArticle Published on 2022-09-022022-11-15 Journal: Medicine [Category] 진단, [키워드] 24 hour abdominal pain acute respiratory syndrome bleeding Blood Case report caused Comorbidity Complication Computed tomography coronavirus coronavirus disease CT scan diagnostic died distal dry cough effective gastrointestinal hemorrhage hemodynamic hemorrhage histopathological Inconclusive indicate initial Intervention life-threatening male massive melena mitotic neoplasm Older age Patient Pelvic Pneumonia polymerase chain positive result postoperative postoperative course reported surgical the patient therapeutic treated Treatment was performed [DOI] 10.1097/MD.0000000000030098 PMC 바로가기
Jetstream Atherectomy Followed by Paclitaxel-Coated Balloons versus Balloon Angioplasty Followed by Paclitaxel-Coated Balloons: Twelve-Month Exploratory Results of the Prospective Randomized JET-RANGER StudyRandomized Controlled Trial Published on 2022-08-022022-10-05 Journal: Vascular Health and Risk Management [Category] 임상, [키워드] Analysis angioplasty assigned association atherectomy bailout stenting balloon Boston claudication COVID-19 death disease dissections distal drug-coated balloons Enrollment evaluated exploratory femoropopliteal Follow-up followed by intention to treat JET Jetstream lesions Medtronic Mortality multicenter outcome Patient patients primary end point Prospective provide Randomized randomized trial Randomly Ranger, In.PACT reduction in Result TLR Treatment two groups variable vessel vessel prepping. was performed were used [DOI] 10.2147/VHRM.S371177 PMC 바로가기 [Article Type] Randomized Controlled Trial
ACE2 expression in adipose tissue is associated with cardio-metabolic risk factors and cell type composition-implications for COVID-19지방 조직에서의 ACE2 발현은 코로나19에 대한 심장 대사 위험 인자 및 세포 유형 구성과 관련이 있습니다.Meta-Analysis Published on 2022-08-012022-09-11 Journal: International journal of obesity (2005) [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, 치료기술, [키워드] ACE2 ACE2 expression adipose Adipose tissue age angiotensin angiotensin I angiotensin I converting enzyme 2 BMI Cell cell type cell types cellular entry contribute COVID-19 COVID-19 severity diabetes Diseases distal Endothelial cell enzyme eQTLs expression Factor Factors fasting insulin feature Genetic HDL Health identify increased risk independent individual insulin investigated loci Lower lower expression Macrophage macrophages Meta-analysis obesity participant pathophysiology phenotypic proportion proximal Quantitative receptor risk risk factor RNA-Seq SARS-CoV-2 serum severe COVID-19 T2D tissue tissue expression type 2 diabete type 2 diabetes [DOI] 10.1038/s41366-022-01136-w PMC 바로가기 [Article Type] Meta-Analysis
SARS-CoV-2 infection of human-induced pluripotent stem cells-derived lung lineage cells evokes inflammatory and chemosensory responses by targeting mitochondrial pathways인간 유도 만능 줄기 세포 유래 폐 계통 세포의 SARS-CoV-2 감염은 미토콘드리아 경로를 표적으로 하여 염증 및 화학 감각 반응을 유발합니다Article Published on 2022-07-012022-09-12 Journal: Journal of cellular physiology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] activated acute respiratory syndrome addition Affect airway alveolar alveolar cells Antiviral Apoptosis caused Cell cells chemosensory chemosensory response Complexes Consequences coronavirus COVID-19 COVID-19 disease COVID-19 patients Defense developmental distal dysregulation epithelial HMOX1 IL-13 IL-6 immune responses in viral in vitro Increased induced pluripotent stem cells INF-γ infected cell Inflammatory Inflammatory response Lineage lung lung epithelial Lung epithelial cells Lung injury lung tissue maturation mechanism metabolic processe mitochondrial mitochondrial damage. pathway precursor Proinflammatory cytokine proximal replicated response resulting robust ROS ROS production SARS-CoV-2 SARS-COV-2 infection spatiotemporal therapeutic drug TNF-α transcriptomics Transport upregulated upregulation [DOI] 10.1002/jcp.30755 PMC 바로가기 [Article Type] Article
Protease inhibitor Camostat Mesyalte blocks wild type SARS-CoV-2 and D614G viral entry in human engineered miniature lungs프로테아제 억제제 Camostat Mesyalte는 인간이 조작한 소형 폐에서 야생형 SARS-CoV-2 및 D614G 바이러스 진입을 차단합니다Article Published on 2022-06-012022-09-11 Journal: Biomaterials [Category] Coronavirus, COVID19(2023년), SARS, 치료제, [키워드] 3D model alveolar alveolar epithelial cell AT2 block camostat catastrophic cell line cell lines COVID-19 Culture D614G develop distal Effect epithelial epithelial cells evaluate Ex vivo highlight human lung in vitro model induce Infection inhibitor involved lentivirus lung lung epithelium maturation moderate organ organ culture organoids pandemic Pathogenesis pathogenesis of COVID-19 phenotype platform pluripotent stem cell Prevent progression Protease inhibitor provided pseudotyped real time reduced Research respiratory tract SARS-CoV-2 SARS-CoV-2 pandemic significantly the SARS-CoV-2 tissue treat type 2 alveolar epithelial cells viral entry viral infection viral infections virulent while wild type wildtype [DOI] 10.1016/j.biomaterials.2022.121509 PMC 바로가기 [Article Type] Article
Lung targeted liposomes for treating ARDSARDS 치료를 위한 폐 표적 리포솜Article Published on 2022-06-012022-09-11 Journal: Journal of controlled release : official journal o [Category] 치료제, [키워드] accumulate accumulation acute respiratory distress acute respiratory distress syndrome Administered administration alveolar approach ARDS BAL Bronchoalveolar lavage C57BL/6 characterized combined treatment COPD COVID-19 COVID-19 infections cysteine cytokine secretion distal DPPC drug Efficiency encapsulation endotracheal exhibited Gas exchange Hypoxemia IL-1β IL-6 impair infections Inflammation Inflammatory marker inflammatory markers intravenous intravenously lipid composition Lipid nanoparticles lipopolysaccharide Liposome lung lung damage Lung diseases lung disorders lung endothelial lung epithelial Lung inflammation Lungs Macrophage macrophages marker medication Methylprednisolone mice mortality rate mortality rates MPS mucolytic agent Mucus N-acetyl cysteine NAC nanoparticle Nanotechnology nitric oxide outcome Patient penetration provided pulmonary Pulmonary. reached reduce reducing Region respiratory respiratory distress Respiratory distress syndrome secretion steroid syndrome therapeutic therapeutic effect therapeutic efficacy TNFα Treatment Treatment outcome were assessed [DOI] 10.1016/j.jconrel.2022.03.028 PMC 바로가기 [Article Type] Article
Allosteric perspective on the mutability and druggability of the SARS-CoV-2 Spike proteinSARS-CoV-2 스파이크 단백질의 돌연변이성 및 약물 가능성에 대한 알로스테릭 관점Article Published on 2022-04-072022-09-11 Journal: Structure (London, England : 1993) [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] addition allosteric drugs allosteric effect allosteric effects allosteric effects of mutations Allostery binding characteristic determine diagnostics disease distal drug drug design druggability drugs Endemic Endemic disease escape mutation mechanisms mutability mutability. Mutation pandemic Perspective Protein recent RNA virus RNA viruses SARS-CoV-2 SARS-CoV-2 spike protein Signaling spike Spike protein the SARS-CoV-2 the spike protein Vaccine variants of concern Viral protein Viral proteins VoC VOCs while [DOI] 10.1016/j.str.2021.12.011 PMC 바로가기 [Article Type] Article