Mechanism of DNA Intercalation by Chloroquine Provides Insights into ToxicityArticle Published on 2024-01-242024-09-05 Journal: International Journal of Molecular Sciences [Category] update2024, [키워드] AFM Chloroquine DNA binding DNA melting Intercalation isothermal titration calorimetry Optical tweezers single molecule [DOI] 10.3390/ijms25031410 PMC 바로가기 [Article Type] Article
Multi-spectroscopic and free energy landscape analysis on the binding of antiviral drug remdesivir with calf thymus DNAResearch article Published on 2022-10-012022-10-05 Journal: Spectrochimica acta. Part A, Molecular and biomole [Category] 치료제, [키워드] Analysis antiviral drug base pair bind binding binding constant Combination complex DNA DNA binding electrostatic interaction experiment free energy landscape Hoechst 33258 increase in indicated Interaction Intercalation investigated Metadynamics NMR parameter phenyl ring phosphate Potassium REM Remdesivir RNA-dependent RNA polymerase shown Significant Simulation simulation studies Spectroscopy suggested supported [DOI] 10.1016/j.saa.2022.121363 [Article Type] Research article
Functional associations between polymorphic regions of the human 3’IgH locus and COVID-19 disease인간 3'IgH 유전자좌의 다형성 영역과 COVID-19 질병 간의 기능적 연관성Article Published on 2022-09-052022-09-11 Journal: Gene [Category] COVID19(2023년), SARS, 변종, [키워드] age allele allelic Allelic polymorphisms Alpha association blood sample Blood samples Clinical outcome clinical outcomes Clinical severity collected coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease COVID-19 patient COVID-19 patients diffusion disease severity disequilibrium distribution DNA binding enhancer enhancer region ERα Estrogen Estrogen receptor alpha exhibited explain Genetic genetic background Genetic variant genetic variants genotyped SNP genotyped SNPs haplotypes heavy chain hospital hs1,2 enhancer. humans hypothese IgH locus immune response Immunoglobulin Infection Italy less linkage locus men MOST nine nucleotide Occurrence pandemic Pneumonia produced protective factor receptor Region SARS-COV-2 infection severe disease sex differences Sex-related differences significantly SNPs women [DOI] 10.1016/j.gene.2022.146698 PMC 바로가기 [Article Type] Article
Insights into the specificity for the interaction of the promiscuous SARS-CoV-2 nucleocapsid protein N-terminal domain with deoxyribonucleic acids난잡한 SARS-CoV-2 뉴클레오캡시드 단백질 N-말단 도메인과 데옥시리보핵산의 상호작용에 대한 특이성에 대한 통찰력Article Published on 2022-04-012022-09-11 Journal: International journal of biological macromolecules [Category] COVID19(2023년), SARS, 치료법, [키워드] activity approximation binding Binding specificity cleft dissect DNA DNA binding DNA/RNA binding protein double-stranded feature inhibitors insight Interaction Local motif multifunctional N-terminal domain non-specific nucleic acid nucleocapsid parameter preference Protein RNA RNA binding protein SARS-CoV-2 nucleocapsid SARS-CoV-2 nucleocapsid protein sequence specificity starting point suggested the N protein therapeutic target thermodynamic thymidine Transcription transcriptional regulatory sequence transcriptional regulatory sequences TRS virus infectivity β-sheet [DOI] 10.1016/j.ijbiomac.2022.01.121 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Spike Glycoprotein S1 Induces Neuroinflammation in BV-2 MicrogliaArticle Published on 2021-10-282022-10-30 Journal: Molecular neurobiology [Category] COVID-19, [키워드] accumulating Activation addition blocked caspase-1 caused CNS contribute coronavirus culture supernatant DNA binding Effect Evidence exposure IL-1β IL-6 immunofluorescence microscopy increase in Increased investigated involved MAPK mechanism microglia Neuroinflammation Neurological symptom NF-κB NF-κB NLRP3 inflammasome pathology pharmacological produced Protein protein expression protein level provided reduction in respiratory complication Result RNA SARS-CoV-2 SARS-CoV-2 spike protein S1 SARS‐CoV‐2 spike Spike protein stimulated supplementary material the disease the spike protein TLR4 TNF-α transcriptional activity was reduced [DOI] 10.1007/s12035-021-02593-6 PMC 바로가기 [Article Type] Article
Induction of Exaggerated Cytokine Production in Human Peripheral Blood Mononuclear Cells by a Recombinant SARS-CoV-2 Spike Glycoprotein S1 and Its Inhibition by DexamethasoneOriginal Article Published on 2021-04-162022-10-30 Journal: Inflammation [Category] COVID-19, MERS, SARS, [키워드] Activation anti-inflammatory activity blocked caused clinical benefit COVID-19 Cytokine storm Cytokines Degradation Dexamethasone DNA binding Effect experiment Human IL-1β IL-6 IL-8 increase in induction Inflammation Inflammatory inhibition investigated involved IκBα MAPK mechanism molecular mononuclear cell NF-KB NF-κB NF-κB activation NLRP3 inflammasome p65 PBMC PBMCs peripheral Peripheral blood pharmacological target Phosphorylation pro-inflammatory cytokine produced Production recombinant reducing reduction reduction in SARS-CoV-2 SARS-CoV-2 cytokine storm SARS-CoV-2 spike glycoprotein SARS-CoV-2 spike glycoprotein S1 SARS-CoV-2 virus infection significantly increased spike spike glycoprotein stimulated Stimulation TNFα was reduced [DOI] 10.1007/s10753-021-01464-5 PMC 바로가기 [Article Type] Original Article
Molecular Dynamics Reveals a DNA-Induced Dynamic Switch Triggering Activation of CRISPR-Cas12a분자 역학은 CRISPR-Cas12a의 활성화를 유발하는 DNA 유도 동적 스위치를 보여줍니다Article Published on 2020-12-282022-09-11 Journal: Journal of Chemical Information and Modeling [Category] SARS, 치료기술, 치료제, [키워드] Activation binding Cas9 catalytic site cleavage conformational coronavirus CRISPR Critical determinant Diagnosis DNA DNA binding domain dynamic Dynamics effort favor Genome IMPROVE induce joint molecular molecular dynamics MOST nonspecific Nuc nucleic acid Nucleic acid detection nucleic acids outcome REC regulator SARS-CoV-2 coronavirus specificity switch tendency the SARS-CoV-2 Viral Viral detection [DOI] 10.1021/acs.jcim.0c00929 PMC 바로가기 [Article Type] Article
Structural changes of antitoxin HigA from Shigella flexneri by binding of its cognate toxin HigBarticle Published on 2019-06-302024-09-01 Journal: International Journal of Biological Macromolecules [Category] 세균성이질, [키워드] conformational change DNA binding HigBA Toxin-Antitoxin system X-ray crystallography [Article Type] article
Non-equilibrium repressor binding kinetics link DNA damage dose to transcriptional timing within the SOS gene network비평형 억제인자 결합 동역학은 SOS 유전자 네트워크 내에서 DNA 손상 용량을 전사 타이밍에 연결합니다Research Article Published on 2018-06-012022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Activation activity bacterial DNA best binding binding interaction binding kinetics Biochemical pathways cause Cell cellular Concentration Critical defined Degradation disequilibrium DNA binding DNA damage DNA damage repair pathway DNA damaging dose drop Escherichia coli expression Gene Expression Genes kinetic leads LexA low dose mechanism modulate network operator operators pathway Physiology promoter promoters rapid equilibrium assumptions regulate regulated Regulatory respond resulting reveal separated SOS gene SOS pathway SOS response subset the cell the timing These data Transcription transcription factor transcription regulation transcriptional transcriptional repressor Trigger triggers [DOI] 10.1371/journal.pgen.1007405 PMC 바로가기 [Article Type] Research Article
Loss of Xist RNA from the inactive X during B cell development is restored in a dynamic YY1-dependent two-step process in activated B cellsB 세포 발달 동안 비활성 X에서 Xist RNA의 손실은 활성화된 B 세포에서 동적 YY1 종속 2단계 과정으로 복원됩니다.Research Article Published on 2017-10-092022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activated Activation adulthood Autoimmune disorders Autoimmunity B cell B cells Cell change chromatin chromosome compensated Critical develop DNA DNA binding domain dosage ectopic expression embryogenesis Epigenetic Ex vivo expression female Genes Genetic heterochromatin Immunity impair inactivation inactive indicate lack Lineage Loss lymphocyte Lymphocytes mechanism Modification modifications pathogenic pattern Recombination regulate regulated restored reveal RNA Stimulation susceptibility transcription factor up-regulation X-linked X-linked gene YY1 Zinc [DOI] 10.1371/journal.pgen.1007050 PMC 바로가기 [Article Type] Research Article