dosages – Communicable Diseases Research

Famotidine activates the vagus nerve inflammatory reflex to attenuate cytokine storm

Famotidine은 미주 신경 염증 반사를 활성화하여 사이토카인 폭풍을 약화시킵니다.

Article

Published on 2022-05-162022-09-11
Journal: Molecular Medicine [Category] 유전자 메커니즘,

New Psychoactive Substances and receding COVID-19 pandemic: really going back to “normal”?

새로운 정신 활성 물질과 코로나19 대유행 퇴조: 정말 "정상"으로 돌아가는가?

Article

Published on 2022-05-112022-09-11
Journal: Acta bio-medica : Atenei Parmensis [Category] COVID19(2023년), SARS, 변종, 치료기술,

[키워드] Abuse agency analogue Analysis appear approach arising available data benzimidazole can not Case report case reports Characteristics check circumvent clonitazene club compounds COVID-19 COVID-19 pandemic criminal criminality Dark Web death deaths derivative detectable detection system disorders diversion dosages drug Drug Abuse early stage early stages ecosystem Effect effective Effects effort Endemic etonitazene European Exacerbation fatality fentanyl FIVE form Health Service Health services healthcare implicated implication increasingly information Interaction involved isotonitazene less magnitude mechanism media metonitazene mistake Mortality New nine NMR NPs opioid opioids Opioids abuse overdose pandemic Probing public health public health emergency Public health responses receptor reduction Reduction potential replicate Research resource rising risk Scientific community seeking selected significantly more social media Still Stress substance substance abuse supply supply and demand Surveillance the SARS-CoV-2 traffickers turn urgency user experience variants web-based platform X-ray diffraction
[DOI] 10.23750/abm.v93i2.13008 PMC 바로가기 [Article Type] Article

Restless legs syndrome severity in the National RLS Opioid Registry during the COVID-19 pandemic

Observational Study

Published on 2022-02-012022-10-05
Journal: Sleep medicine [Category] 임상,

Lung Ultrasound in Patients With SARS‐COV ‐2 Pneumonia Correlations With Chest Computed Tomography, Respiratory Impairment, and Inflammatory Cascade

SARS-COV ‐2 폐렴 환자의 폐 초음파와 흉부 컴퓨터 단층 촬영, 호흡 장애 및 염증 캐스케이드 상관 관계

Original Research

Published on 2021-09-172022-09-10
Journal: Journal of Ultrasound in Medicine [Category] COVID19(2023년), MERS, SARS, 치료기술,

[키워드] affected association Blood blood gas C‐reactive protein calculated characteristics of patient Chest computed tomography Chest CT comparable Computed tomography consecutive patient consecutive patients correlated correlation COVID‐19 COVID‐19 cytokine cascade dosages Hospitalization hospitalized patient hospitalized patients IL‐6 impairment index Inflammation Inflammatory response Interstitial lung disease involved lung Lung disease Lung function lung involvement Lung ultrasound marker objective P / F parenchymal pathology Patient performed Pneumonia respiratory Result SARS‐CoV‐2 sensitivity severity Symptoms Ultrasound were assessed women
[DOI] 10.1002/jum.15831 PMC 바로가기 [Article Type] Original Research

A phase I study of high dose camostat mesylate in healthy adults provides a rationale to repurpose the TMPRSS2 inhibitor for the treatment of COVID-19

건강한 성인을 대상으로 한 고용량 카모스타트 메실레이트에 대한 1상 연구는 COVID-19 치료를 위해 TMPRSS2 억제제를 용도 변경하는 근거를 제공합니다

Clinical Trial

Published on 2021-09-012022-09-11
Journal: Clinical and translational science [Category] 신약개발, 임상,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Administered camostat Camostat mesylate Cell chronic pancreatitis Concentration conducted coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 dosages effective evaluated half-maximal effective concentration healthy High dose High-dose Infection inhibit inhibiting meal metabolite no significant difference Pancreatitis Phase I Phenylacetic acid plasma provide reflux esophagitis reported respiratory Safe safety profile Serine serine protease inhibitor severe acute respiratory syndrome Coronavirus significantly Simulation TMPRSS2 inhibitor transmembrane serine protease treat Treatment type II transmembrane serine protease
[DOI] 10.1111/cts.13052 PMC 바로가기 [Article Type] Clinical Trial

Systemic corticosteroids for the treatment of COVID-19

COVID-19 치료를 위한 전신 코르티코스테로이드

Review

Published on 2021-08-162022-09-11
Journal: The Cochrane database of systematic reviews [Category] SARS, 임상,

[키워드] 95% CI 95% confidence interval acute respiratory syndrome adjust adverse event adverse events age all-cause mortality analysed Analysis applicability approach arising Arm Asymptomatic asymptomatic infection baseline benefit caution CENTRAL certainty certainty of evidence change citation Cochrane COVID-19 Study Register Combination comparison Comparisons composite endpoint control group coronavirus disease coronavirus diseases Corticosteroid Corticosteroids COVID-19 Data collection death Descriptive statistics Dexamethasone Diagnosis direction disease disease severity dosage dosages dose doses doses of corticosteroids effective Effects eligible endpoints estimate Ethnicity evaluated Evidence excluded Factor FIVE Follow-up Gender heterogeneous high risk hospital-acquired infections hospitalised hyper-inflammation identify include index individual Inhaled inhaled corticosteroids inherent invasive Invasive mechanical ventilation invasive ventilation life limitation long-COVID majority median medRxiv methodology Methylprednisolone Middle East Middle East respiratory syndrome Mild Mild disease Mortality MOST New nine non-hospitalised occurred Other outcomes outcome outcomes Outpatient outpatients participant Participants Patient people with COVID-19 Placebo Population Quality Quality of life randomisation randomised randomised controlled trial Randomised controlled trials RCT RCTs reduce reduction in regimen reported Respiratory Support risk risk difference risk of bia risk ratio Safe Science Citation Index searched Selection Serious Adverse Events Severe acute respiratory syndrome standard care subgroup subgroups subsequent suspected diagnosis symptomatic symptomatic COVID-19 syndrome systematic review systemic systemic corticosteroid systemic corticosteroids the WHO therapy topical treat Treatment Trial Ventilation ventilator-free day Ventilator-free days Web of Science WHO ICTRP
[DOI] 10.1002/14651858.CD014963 PMC 바로가기 [Article Type] Review

High sedation needs of critically ill COVID-19 ARDS patients—A monocentric observational study

Research Article

Published on 2021-07-272022-10-28
Journal: PLoS ONE [Category] COVID-19,

[키워드] 2019 coronavirus disease acute respiratory distress Affect affected age Analgesia Analysis ARDS association Combination coronavirus COVID-19 COVID-19 patient Critical care Critically ill Critically ill patient Data analysis demographic data dosage dosages dose ECMO global pandemic infused intensive care intubated patient intubation Logistic regression majority mechanically ventilated mechanically ventilated patient observation Patient performed prone positioning recorded regimen required Respiratory failure Result retrospective Sedation syndrome therapy Treatment Ventilation was used with COVID-19
[DOI] 10.1371/journal.pone.0253778 PMC 바로가기 [Article Type] Research Article

Factors associated with COVID-19-related death in people with rheumatic diseases: results from the COVID-19 Global Rheumatology Alliance physician-reported registry

류마티스 질환이 있는 사람의 COVID-19 관련 사망과 관련된 요인: COVID-19 Global Rheumatology Alliance 의사 보고 레지스트리의 결과

Article

Published on 2021-07-012022-09-12
Journal: Annals of the rheumatic diseases [Category] Fulltext, SARS, 진단,

[키워드] 1.26 95% CI age Alliance antirheumatic agents association Autoimmune Autoimmune diseases cardiovascular disease caution Comorbidities covariate COVID-19 COVID-19-related death Cyclophosphamide death determine died disease Disease activity Disease diagnosis dosage dosages Epidemiology Factor female glucocorticoid Glucocorticoids Health Health care higher odd highlight hypertension Immunosuppressant immunosuppressants Lung disease Male sex medication medications methotrexate monotherapy multivariable logistic regression Older age Other outcome outcome assessment Patient Primary outcome receiving required Rheumatic diseases rituximab Sex smoking status stratified sulfasalazine
[DOI] 10.1136/annrheumdis-2020-219498 PMC 바로가기 [Article Type] Article

Tozinameran (BNT162b2) Vaccine: The Journey from Preclinical Research to Clinical Trials and Authorization

Tozinameran (BNT162B2) 백신 : 전임상 연구에서 임상 시험 및 승인으로의 여정

Review

Published on 2021-06-072022-08-31
Journal: AAPS PharmSciTech [Category] MERS, SARS, 신약개발, 임상, 진단,

[키워드] Administered administration adolescents adverse effects age antibody Antibody Response authorization bind BioNTech BNT162b1 BNT162b2 BNT162b2 vaccine BNT162b2 vaccines children clinical clinical trial clinical trials COVID-19 dosages Efficacy ENCODE EUA exhibited expected expression first dose host cells immune response Immunity individual Lipid nanoparticle Lipid nanoparticles mRNA Neutralizing antibodies of BNT162b2 Older operation participant Pfizer Pfizer-BioNTech Phase 1 phase 1 trials phase 1/2 trials Phase 2 phase 2 trials phase 2/ 3 trials phase 2/3 Phase 3 Phase 3 trials Preclinical preclinical studies preclinical trials pregnant pregnant women question real-world outcomes receive reported RNA robust S antigen Safety SARS-CoV-2 SARS-CoV-2 spike protein speed Spike protein Support the SARS-CoV-2 Tozinameran transfer Trial Vaccine
[DOI] 10.1208/s12249-021-02058-y PMC 바로가기 [Article Type] Review

Practical Advices for Treating Chronic Pain in the Time of COVID-19: A Narrative Review Focusing on Interventional Techniques

Review

Published on 2021-05-252022-10-30
Journal: Journal of Clinical Medicine [Category] COVID-19,