Identification and evaluation of potential SARS-CoV-2 antiviral agents targeting mRNA cap guanine N7-MethyltransferasemRNA 캡 구아닌 N7-메틸트랜스퍼라제를 표적으로 하는 잠재적인 SARS-CoV-2 항바이러스제의 식별 및 평가Article Published on 2021-09-012022-09-11 Journal: Antiviral Research [Category] SARS, 치료제, [키워드] analyzed antiviral activity antiviral agent approach assays binding binding site Cell Compound COVID-19 COVID-19 pandemic dot blot Drug discovery ENCODE enzyme FIVE Fluorescence fluorescence anisotropy Fluorescence assay guanine HPLC identification identify inhibitor Inhibitor screening inhibitory effect Inhibitory effects insight involved mRNA novel nsp14 SARS-CoV-2 screened Structure tested therapeutic intervention therapeutic interventions to define [DOI] 10.1016/j.antiviral.2021.105142 PMC 바로가기 [Article Type] Article
The Nucleocapsid protein triggers the main humoral immune response in COVID-19 patients뉴클레오캡시드 단백질은 COVID-19 환자의 주요 체액성 면역 반응을 유발합니다Article Published on 2021-03-052022-09-11 Journal: Biochemical and Biophysical Research Communication [Category] SARS, 진단, 치료기술, 치료법, [키워드] addition Amino acid amino acids Antibody Response caused control patient control patients coronavirus COVID-19 COVID-19 antibody COVID-19 pandemic COVID-19 patient COVID-19 patients detect develop dot blot Epitopes fragment full length generate help humoral immune response identify IgG antibody immune immune response immunoreactivity Immunotest infected patient infected patients M protein membrane membrane protein MOST N protein nucleocapsid nucleocapsid protein other coronaviruses Patient positive positive immune response Protein S protein SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-COV-2 infection selectivity spike Spike protein the N protein the S protein Trigger Vaccine Vaccine development Viral viral particle virus [DOI] 10.1016/j.bbrc.2021.01.073 PMC 바로가기 [Article Type] Article