Randomized, double-blind, placebo-controlled, crossover trial of oral doxycycline for epistaxis in hereditary hemorrhagic telangiectasiaArticle Published on 2022-11-072022-11-16 Journal: Orphanet Journal of Rare Diseases [Category] 유전자 메커니즘, [키워드] analysis Angiogenesis assigned Biomarkers bleeding Blood center double-blind doxycycline Effectiveness ENG Epistaxis Frequency heart failure help hemorrhage Hemorrhagic Hereditary Hereditary hemorrhagic telangiectasia Hereditary hemorrhagic telangiectasia. HHT IL-6 Inflammatory intravenous limitations Liver disease malformation marker mechanism Michael morbidity no significant difference not significantly different observation pathway Patient Placebo placebo-controlled provided Quality of life Randomized controlled trial Randomly RBC recruited Registered Registration secondary significantly higher stroke telangiectasia therapy Toronto Treatment treatment period Trial VEGF [DOI] 10.1186/s13023-022-02539-8 PMC 바로가기
Monkeypox proctitis treated with doxycycline in an HIV MSM returning to Italy from FranceArticle Published on 2022-11-012023-06-10 Journal: Travel medicine and infectious disease [Category] Fulltext, 원숭이두창, [키워드] Anal pain doxycycline lymphogranuloma venereum Monkeypox virus proctitis. [DOI] 10.1016/j.tmaid.2022.102469 PMC 바로가기
COVID-19 prophylaxis with doxycycline and zinc in health care workers: a prospective, randomized, double-blind clinical trialRandomized Controlled Trial Published on 2022-09-012022-10-04 Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 임상, 치료기술, 치료제, [키워드] Asthma Care chronic obstructive clinical trial Combination combination treatment conducted control groups COVID-19 COVID-19 infection Cycle threshold value decrease demonstrated determine diabete dose double-blind doxycycline Effectiveness Efficacy Health Health care worker hypertension indicated Infection Participants patients with SARS-CoV-2 Placebo polymerase chain prevention of COVID-19 Prophylactic Prophylaxis protective effect pulmonary disease Randomized reduced reverse transcription risk SARS-CoV-2 SARS-COV-2 infection significant decrease therapy Treatment Viral load was measured Zinc zinc. [DOI] 10.1016/j.ijid.2022.06.016 PMC 바로가기 [Article Type] Randomized Controlled Trial
Impacts of the COVID-19 pandemic on pharmaceuticals in wastewater treated for beneficial reuse: Two case studies in central PennsylvaniaArticle Published on 2022-09-012022-11-16 Journal: Journal of environmental quality [Category] 치료기술, [키워드] acute respiratory syndrome affected analyzed Antibiotics Area authority calculated collected Concentration concentrations connection coronavirus COVID-19 pandemic Dexamethasone doxycycline effective explained facility FIVE Health highlight hospitalized patient Hydroxychloroquine Impact Medicine no correlation occurred pandemic patients with COVID-19 persistence plant plants powerful tool Quotient Reclamation Remdesivir returned reuse risk Sample state Surveillance therapeutic agent treated Treatment university utility Variation virus water with COVID-19 would increase [DOI] 10.1002/jeq2.20398 PMC 바로가기
Broadly Applicable, Virus-Free Dual Reporter Assay to Identify Compounds Interfering with Membrane Fusion: Performance for HSV-1 and SARS-CoV-2막 융합을 방해하는 화합물을 식별하기 위해 광범위하게 적용 가능한 바이러스 없는 이중 보고자 분석: HSV-1 및 SARS-CoV-2에 대한 성능Article Published on 2022-06-212022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] alkaline alkaline phosphatase antiviral agent Antiviral agents cell-cell fusion cell–cell fusion Compound doxycycline dual reporter assay Efficacy enzyme expressed expression fluorescent fusion inhibition HSV-1 identify inhibitors Internal control marker membrane fusion nanoluciferase nuclear Pathogens performance phosphatase quantification Replication reported reporter reporter fusion reporter gene SARS-CoV-2 secreted secreted alkaline phosphatase secreted nanoluciferase. Sensitivity and specificity Tetracycline transient transfection Vero Cell Vero cells viral pathogens was tested [DOI] 10.3390/v14071354 PMC 바로가기 [Article Type] Article
Repurposing tetracyclines for acute respiratory distress syndrome (ARDS) and severe COVID-19: a critical discussion of recent publications급성 호흡 곤란 증후군(ARDS) 및 중증 COVID-19에 대한 테트라사이클린 용도 변경: 최근 간행물에 대한 비판적 논의Article Published on 2022-05-012022-09-11 Journal: Expert opinion on investigational drugs [Category] COVID19(2023년), SARS, 신약개발, [키워드] activities acute respiratory distress acute respiratory distress syndrome addition antibiotic antiviral activity approach ARDS Area benefit Combination COVID-19 COVID-19 pandemic COVID-19 patients Critical doxycycline Drug repurposing Effectiveness Efficacy Evidence expert fibrosis immunomodulatory incyclinide inflammatory reaction initial limitation limitations Minocycline overcome pharmacological repurposing repurposing. respiratory distress Respiratory distress syndrome safety profile SARS-CoV2 scarcity scientific evidence severe COVID-19 shown syndrome Tetracycline tetracyclines therapeutic potential therapy [DOI] 10.1080/13543784.2022.2054325 PMC 바로가기 [Article Type] Article
Combined therapy with ivermectin and doxycycline can effectively alleviate the cytokine storm of COVID-19 infection amid vaccination drive: A narrative reviewReview Published on 2022-03-302023-06-15 Journal: Journal of infection and public health [Category] COVID19(2023년), MERS, SARS, [키워드] combination therapy COVID-19 infection Cytokine storm doxycycline Ivermectin SARS-CoV-2 [DOI] 10.1016/j.jiph.2022.03.014 PMC 바로가기 [Article Type] Review
Effectiveness of ivermectin-based multidrug therapy in severely hypoxic, ambulatory COVID-19 patientsShort Communication Published on 2022-02-092022-10-31 Journal: Future Microbiology [Category] COVID-19, COVID19(2023년), SARS, [키워드] Administered average CDC clinical clinical observations Combination combination therapy controlled trials controls coronavirus COVID COVID-19 COVID-19 patient database deaths doxycycline effective Features Helicobacter pylori Hospitalization hypoxia hypoxic Ivermectin less moderate Outpatient oxygen saturation random resolved Result Safe SARS-CoV-2 subject Symptom Symptoms therapeutic therapy Treatment Vitamin Zinc [DOI] 10.2217/fmb-2022-0014 PMC 바로가기 [Article Type] Short Communication
Drug-induced esophageal injuries with an atypical presentation mimicking acute coronary syndromeCase Report Published on 2021-12-202023-08-28 Journal: BMC Gastroenterology [Category] E형 간염, [키워드] Acute coronary syndrome doxycycline drug-induced Esophageal injury esophagitis mimicking Pill-induced [DOI] 10.1186/s12876-021-02063-2 PMC 바로가기 [Article Type] Case Report
COVID-19 Infection Clinical Profile, Management, Outcome, and Antibody Response in Kidney Transplant Recipients: A Single Centre ExperienceResearch Article Published on 2021-10-032022-10-29 Journal: International Journal of Nephrology [Category] COVID-19, [키워드] age AKI analyzed Antibiotics Antibody Response Blood Blood Group blood urea clinical CNI Confirmed COVID-19 infection convalescent plasma COVID-19 Culture dialysis doxycycline experience Factor hospitalized patients ICU care IgG antibody inhibitor interleukin-6 IQR Ivermectin Kidney injury kidney transplant recipient Laboratory low molecular weight management Material and Method median value Mortality mortality rate mounted nonsurvivor nonsurvivors not significantly different outcomes overall mortality Patient PCR pharmacological management polymerase chain positive presenting profile recovered Remdesivir reported response Result retrospective Risk factors SARS-CoV-2 serum albumin severity Significant statistically significant steroid Support survivor Survivors therapy Tocilizumab Transplant Treatment ventilated patient Ventilation was collected with COVID-19 [DOI] 10.1155/2021/3129411 PMC 바로가기 [Article Type] Research Article