Planetary health & COVID-19: A multi-perspective investigationReview article Published on 2022-12-012022-10-05 Journal: One Health [Category] 신약개발, [키워드] characterized complex COVID-19 driver Drivers growth Health Impact implication Implications indicate influence literature review outcome Planetary health public health SDGs spread of COVID-19 Stress wet markets [DOI] 10.1016/j.onehlt.2022.100416 [Article Type] Review article
Spatiotemporal clusters and the socioeconomic determinants of COVID-19 in Toronto neighbourhoods, CanadaResearch article Published on 2022-11-012022-10-05 Journal: Spatial and spatio-temporal epidemiology [Category] 진단, 치료기술, [키워드] affecting Canada Cluster Clustering analysis COVID-19 determinant driver effective epidemiological explain identify Intervention Local Multiscale geographically weighted regression (mgwr) predictor Regression model regression models Space-time clusters Spatial regression spatiotemporal Toronto variable were used [DOI] 10.1016/j.sste.2022.100534 [Article Type] Research article
Differential Infectivity of Original and Delta Variants of SARS-CoV-2 in Children Compared to AdultsArticle Published on 2022-10-262022-11-16 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome Adults age aliquot B.1.617.2 Canada characteristic children circulating circulating SARS-CoV-2 variants coronavirus COVID-19 Culture cycle threshold Delta delta variant demographics determine dose driver implicated in viral Infection infectious titers infective Infectivity mechanism Mutation Nasopharyngeal swab nasopharyngeal swab sample original pediatric positive predominant provided RT-PCR SARS-CoV-2 SARS-CoV-2 RT-PCR screened statistical analysis susceptible TCID TCID50 TCID50. tissue Transmission variant variants of concern variety Viral RNA VoC [DOI] 10.1128/spectrum.00395-22 PMC 바로가기
Interpreting global variations in the toll of COVID-19: The case for context and nuance in hypothesis generation and testingArticle Published on 2022-10-192022-11-16 Journal: Frontiers in Public Health [Category] COVID19(2023년), SARS, 변종, [키워드] affecting aggregate aggregates Analysis analyzed benefit Biomarker Biomarkers cause-specific mortality country covariate COVID COVID-19 COVID-19 pandemic database domain domains driver ecological events extension Factor Factors flexible Health health economics Health policy Hypothesis Interaction interactions Interpreting Isolation joint Lifestyle factors machine learning morbidity National obesity OLS omicron outcome outcomes pandemic Policy Population populations potential risk response SARS-CoV-2 socioeconomics statistical statistical methods. These data variant variants Variation while [DOI] 10.3389/fpubh.2022.1010011 PMC 바로가기
Longitudinal characterization of circulating neutrophils uncovers phenotypes associated with severity in hospitalized COVID-19 patientsArticle Published on 2022-10-182022-11-15 Journal: Cell Reports Medicine [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome antibody profiling blood sample cell death circulating neutrophil contributing to Control coronavirus COVID-19 degranulation disease disease severity driver dysregulated elevated experiment functions G-MDSC gene expression signature Granulocytic healthy donor hospitalized COVID-19 hospitalized COVID-19 patient Humoral response identify IgA IgA antibody IgG antibody Immunoglobulin induce longitudinal Mortality NETosis neutrophil Neutrophils Patient phagocytosis phenotype plasma plasma proteomics response RNA sequencing SARS-CoV-2 severe coronavirus disease severe COVID-19 severe disease Severe patient severity Subtypes survived transcriptomics [DOI] 10.1016/j.xcrm.2022.100779 PMC 바로가기
Repurposing SGLT-2 Inhibitors to Target Aging: Available Evidence and Molecular MechanismsArticle Published on 2022-10-142022-11-15 Journal: International Journal of Molecular Sciences [Category] 신약개발, 진단, [키워드] accompanied activity addition aging all-cause mortality animal model animal models available data benefit Biomarker blunt caloric restriction calories cardiovascular diseases Cardiovascular outcomes cellular senescence clinical study clinical trials Compound COVID-19 decrease diabetes driver drug drugs employment Evidence Fatty acid feature Glucose heart failure humans IL-6 independent inflammaging Inflammasome inhibitor inhibitors intrinsic Kidney disease low-grade inflammation Meta-analysis modulating modulation molecular Mortality nutrient-sensing pathways observational studies outcomes pathway Patient promote provided repurposing selected senescence sodium-glucose cotransporter 2 inhibitors. substrates suggested Support systemic effects systemic level target Urine [DOI] 10.3390/ijms232012325 PMC 바로가기
Targeting thromboinflammation in COVID-19 – A narrative review of the potential of C1 inhibitor to prevent disease progressionReview Published on 2022-10-012022-10-05 Journal: Molecular immunology [Category] COVID19(2023년), SARS, 신약개발, 임상, 진단, 치료제, [키워드] Activation addition Anti-inflammatory anticoagulation Antiviral Asymptomatic carrier C1 inhibitor cascade cascades caused Clinical practice complement complement system Complication Contact contact activation system Coronavirus disease 2019 COVID-19 Critically ill patient death disease driver drug Endothelial cell Evidence Inflammatory inhibitor introduced kallikrein-kinin Kallikrein-kinin system monoclonal antibodies multisystemic myocardial injury pandemic potential benefit prevent disease progression randomized study randomized trials SARS-CoV-2 severe COVID-19 syndrome targeting the disease therapeutic option Thromboembolic events Thromboinflammation Treatment Trial [DOI] 10.1016/j.molimm.2022.08.008 [Article Type] Review
Long Covid: where we stand and challenges aheadArticle Published on 2022-10-012022-11-15 Journal: Cell Death and Differentiation [Category] COVID19(2023년), SARS, 진단, [키워드] addition Affect Autoimmunity Brain Breakthrough infection cardiovascular system complex defined disease driver EBV Health care system Inflammation initial kidney Long Lungs manifestation mechanism multifactorial organ organs other organ PASC Pathogenesis pathway persistence reduce SARS-CoV-2 SARS-COV-2 infection Symptom therapeutic approaches tissue vaccination virus [DOI] 10.1038/s41418-022-01052-6 PMC 바로가기
Untargeted saliva metabolomics by liquid chromatography-Mass spectrometry reveals markers of COVID-19 severityArticle Published on 2022-09-222022-11-15 Journal: PLoS ONE [Category] 바이오마커, 변종, [키워드] Amino acid amino acids analysed Analysis C-reactive protein Clinical diagnosis Clinical severity clinical suspicion Clinical tests collected COVID-19 COVID-19 diagnosis COVID-19 pandemic COVID-19 patient COVID-19 patients COVID-19 severity Diagnosis diagnostic Disease progression driver dysregulation eliminating expand exploratory feature Health hospital hospitalised patient likelihood marker metabolomics Metadata Non-invasive offer outcomes Patient patients peripheral oxygen saturation Prognosis progressed receiver operating characteristics recent Research reservoir respiratory rate resulting reveal RT-PCR testing Saliva saliva sample serum severity shown the disease Treatment Vaccine variants [DOI] 10.1371/journal.pone.0274967 PMC 바로가기
Transmission Patterns of Seasonal Influenza in China between 2010 and 2018Article Published on 2022-09-172023-06-23 Journal: Viruses [Category] 신종인플루엔자, [키워드] China driver initiating area Seasonal influenza Transmission [DOI] 10.3390/v14092063 PMC 바로가기