Alternative in-vivo models of mucormycosisCellular and Infection Microbiology Review Published on 2024-02-012024-09-05 Journal: Frontiers in Cellular and Infection Microbiology [Category] update2024, [키워드] alternative model organisms Bombyx mori Caenorhabditis elegans Danio rerio Drosophila melanogaster Galleria mellonella Mucormycosis [DOI] 10.3389/fcimb.2024.1343834 PMC 바로가기 [Article Type] Cellular and Infection Microbiology Review
The Drosophila melanogaster ACE2 ortholog genes are differently expressed in obesity/diabetes and aging models: Implications for COVID-19 pathologyArticle Published on 2022-12-012022-11-15 Journal: Biochimica et biophysica acta. Molecular basis of [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] ACE2 ACE2 ortholog ACE2 orthologs ACE2 receptor Acer age analyzed Ance animal model approach bind binding affinity complement coronavirus disease COVID-19 COVID-19 pathology COVID-19 severity death dependent on diabetes disorders Drosophila melanogaster Effect elderly ENhance expressed Factors glycoprotein host cells humans increase individual interact Interaction molecular molecular docking mRNA expression obesity ortholog predicted Protein regions regulated Research responsible risk factor Risk factors robust SARS-CoV-2 SARS-CoV-2 variant shown spike spike-ACE2 susceptible the Spike translational Transmissibility virus [DOI] 10.1016/j.bbadis.2022.166551 PMC 바로가기
ACE and ACE2: insights from Drosophila and implications for COVID-19Review article Published on 2021-12-072022-10-05 Journal: Heliyon [Category] 변종, [키워드] accelerated ACE ACE2 Acer acute respiratory syndrome addition Ance Biochemistry Cardiovascular function catalytically cellular entry conserved coronavirus coronavirus disease COVID-19 COVID-19 pandemic Drosophila Drosophila melanogaster enzyme function functional highlight homologue homology identify implication in vivo knowledge mammalian organism orthologue pathogenicity peptides provide raise recent receptor renin-angiotensin system Research responsible SARS-CoV-2 therapeutic intervention unique utility Vaccine variants various coronaviruses Vasoactive Virus-host interaction [DOI] 10.1016/j.heliyon.2021.e08555 [Article Type] Review article
OGT Protein Interaction Network (OGT-PIN): A Curated Database of Experimentally Identified Interaction Proteins of OGTArticle Published on 2021-09-062022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] Arabidopsis thaliana Cell cells cellular database dataset determine DNA repair Drosophila melanogaster enzyme functional Homo sapien hub protein human protein Identified Interaction its target proteins metabolism molecular network Mus network O-GlcNAc OGT OGT interactome Protein Protein–protein interaction protein–protein interactions Rattus Regulation Repository RNA significant enrichment Transcription translational [DOI] 10.3390/ijms22179620 PMC 바로가기 [Article Type] Article
Identification of new Anopheles gambiae transcriptional enhancers using a cross-species prediction approacharticle Published on 2021-08-312024-09-01 Journal: Insect Molecular Biology [Category] 말라리아, [키워드] Cis-regulatory element computational enhancer prediction cross-species enhancer discovery Drosophila melanogaster malaria Mosquito control regulatory genomics vector biology [Article Type] article
The potential use of Drosophila as an in vivo model organism for COVID-19-related research: a reviewArticle Published on 2021-08-302022-10-29 Journal: Turkish Journal of Biology [Category] COVID-19, [키워드] Antiviral antiviral drug approach Bacterial infections clinical manifestation coronavirus coronavirus disease COVID-19 COVID-19 infection COVID-19 pandemic CRISPR-Cas systems Diseases Drosophila Drosophila melanogaster Drug screening Effect effective Efficiency effort feature functional Health healthcare help homologs human disease models in vivo model knowledge Mutation offer organism pandemic raise report representing SARS-CoV-2 scientist shown significantly trajectory transmissible variant undergo Vaccine viruses [DOI] 10.3906/biy-2104-26 PMC 바로가기 [Article Type] Article
Utilizing comparative models in biomedical researchResearch article Published on 2021-08-012022-10-05 Journal: Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology [Category] 비임상, [키워드] biochemical Biochemistry Biomedical research Caenorhabditis elegans Community Comparative Danio developmental disease Drosophila melanogaster example invertebrate issue knowledge less mechanisms pathology physiological Physiology unique vertebrates while Xenopus [DOI] 10.1016/j.cbpb.2021.110593 [Article Type] Research article
Potential Application of Drosophila melanogaster as a Model Organism in COVID-19-Related ResearchPharmacology Published on 2020-09-042022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] application COVID-19 Drosophila melanogaster fruit fly in vitro in vivo Model model organism Potential RNAi screening SARS-CoV 2 [DOI] 10.3389/fphar.2020.588561 PMC 바로가기 [Article Type] Pharmacology
Transcriptional and genomic parallels between the monoxenous parasite Herpetomonas muscarum and Leishmania일산화 기생충 Herpetomonas muscarum과 Leishmania 사이의 전사 및 게놈 유사점Research Article Published on 2019-11-112022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] biting flies causative agents conserved Culture Diptera disease Drosophila melanogaster early stage early stages event Gene regulation Genome genomic highlighting Host hosts Human identify in vitro infect Infection infections insect Insects Interaction Leishmania Leishmania major Leishmaniasis less mammal mammalian mammals monoxenous parasites MOST Neglected NTDs parasite parasites Regulation reported Sand similarity sleeping sickness Transcriptome Transmission transmitted Tropical Diseases Trypanosome turn vector [DOI] 10.1371/journal.pgen.1008452 PMC 바로가기 [Article Type] Research Article
A conserved role of the insulin-like signaling pathway in diet-dependent uric acid pathologies in Drosophila melanogasterDrosophila melanogaster의 식이 의존성 요산 병리학에서 인슐린 유사 신호 전달 경로의 보존된 역할Research Article Published on 2019-08-152022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] affecting AKT2 arising association Author benefit candidate gene cascade changes in chronic disease Chronic diseases clinical Clinical studies component components conserved Coronary artery Coronary artery disease correlation Degradation diabetes disease disorders downstream Drosophila Drosophila melanogaster drug target Effect elevated expression Factor FOXO3 Genetic Gout Human humans Hyperuricemia hyperuricosuria insulin kidney kidney stone kidney stones knockdown mechanism metabolic syndrome metabolism modulating Multiple NADPH NADPH oxidase norm obesity Occurrence opens Pathogenesis Pathologies pathology pathway phenotype plethora potential therapeutic target potential therapeutic targets Protein purine purines raise reduced Regulatory rescued Research respond risk factor serum shown Signaling signaling pathway SNP SNPs sugar Support syndrome to define treat uric acid Urine vascular disorder yeast extract [DOI] 10.1371/journal.pgen.1008318 PMC 바로가기 [Article Type] Research Article