Chasing COVID-19 chemotherapeutics without putting the cart before the horseArticle Published on 2023-01-012023-07-11 Journal: British Journal of Clinical Pharmacology [Category] SARS, [키워드] coronavirus Drug development equitable access repurposing. SARS-CoV-2 [DOI] 10.1111/bcp.14575 PMC 바로가기
Focus on Marine Animal Safety and Marine Bioresources in Response to the SARS-CoV-2 CrisisReview Published on 2022-12-012023-07-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), [키워드] anti-SARS-CoV-2 COVID-19 Drug development marine mammals marine metabolites. [DOI] 10.3390/ijms232315136 PMC 바로가기 [Article Type] Review
Discovery of potent benzoxaborole inhibitors against SARS-CoV-2 main and dengue virus proteasesSARS-CoV-2 주요 및 뎅기 바이러스 프로테아제에 대한 강력한 벤족사보롤 억제제의 발견Article Published on 2022-10-052022-09-11 Journal: European journal of medicinal chemistry [Category] COVID19(2023년), SARS, 치료제, [키워드] antiviral agent Antiviral agents biochemical assay Cell Cell culture class contribute cytotoxicity demonstrated Dengue dengue virus DENV-2 Drug development evaluated had no Health inhibit inhibitor M pro membrane MOST penetration protease Proteases Replication RNA virus RNA viruses SARS-CoV-2 stability synthesis target targets [DOI] 10.1016/j.ejmech.2022.114585 PMC 바로가기 [Article Type] Article
Novel flavonoid hybrids as potent antiviral agents against hepatitis A: Design, synthesis and biological evaluationArticle Published on 2022-08-052023-05-31 Journal: European journal of medicinal chemistry [Category] A형 간염, [키워드] Anti-HAV activity Drug development Flavonoid hybrids HAV-Replication inhibitors. [DOI] 10.1016/j.ejmech.2022.114452 PMC 바로가기
The impact of SARS-CoV-2 treatment on the cardiovascular system: an updated reviewReview Published on 2022-08-012023-07-09 Journal: Inflammopharmacology [Category] COVID19(2023년), [키워드] cardiovascular diseases COVID-19 Drug development SARS-CoV-2. [DOI] 10.1007/s10787-022-01009-8 PMC 바로가기 [Article Type] Review
Immunological biomarker discovery in cure regimens for chronic hepatitis B virus infectionReview Published on 2022-08-012023-06-11 Journal: Journal of hepatology [Category] B형 간염, [키워드] clinical trial Drug development hepatitis B immunology therapy Viral hepatitis. [DOI] 10.1016/j.jhep.2022.02.020 PMC 바로가기 [Article Type] Review
Low molecular weight chitooligosaccharide inhibits infection of SARS-CoV-2 in vitro저분자량 키토올리고당은 시험관 내에서 SARS-CoV-2의 감염을 억제합니다Article Published on 2022-08-012022-09-11 Journal: Journal of Applied Microbiology [Category] COVID19(2023년), SARS, 치료법, 치료제, [키워드] Analysis Antiviral Antiviral effect antiviral effects candidate chitooligosaccharide chitosan COVID-19 cytotoxicity dose-dependent manner Drug development E gene fluorescence intensity gel in vitro infected cells Infection inhibit low molecular weight molecular weight MTT natural antiviral natural treatment. permeation Plaque assay Protein Quantitative RdRP respond SARS-CoV-2 SARS-CoV-2 nucleocapsid SARS-CoV-2 virus Significance suggested tested the SARS-CoV-2 virus Treatment Vero cells Viral RNA virus-infected cell virus-infected cells was measured [DOI] 10.1111/jam.15618 PMC 바로가기 [Article Type] Article
Potential medicinal plants involved in inhibiting 3CLpro activity: A practical alternate approach to combating COVID-19Review article Published on 2022-08-012022-10-05 Journal: Journal of integrative medicine [Category] SARS, 변종, 치료제, [키워드] 3CLpro acute respiratory syndrome Angelica antiviral drug approach approved Camellia sinensis celastrol combating Compound compounds coronavirus Coronavirus 3C proteases coronavirus disease COVID-19 dose-dependent Drug development drugs Ecklonia cava effective facilitate gallate Glycosides Google Scholar help host cells IC50 inhibiting inhibitory concentration inhibitory effect involved less medicinal plants pharmacological target plant Plant-derived compounds Potential protease Replication Salvia miltiorrhiza SARS-CoV SARS-CoV-2 shown tested Torreya nucifera Treatment Vaccine variety Web of Science were used World Health Organization [DOI] 10.1016/j.joim.2022.08.001 [Article Type] Review article
Drug repurposing: a systematic review on root causes, barriers and facilitators약물 용도 : 근본 원인, 장벽 및 촉진자에 대한 체계적인 검토Article Published on 2022-07-292022-08-31 Journal: BMC health services research [Category] 신약개발, [키워드] Analysis approach article articles business causes Characteristics Cochrane Library Collection complex Compound consolidation core database disease drug Drug abandonment Drug development Efficacy eligible Emergency use authorization example facilitate facilitator facilitators focus food Food and Drug Administration Google Scholar Inadequate include information intellectual property knowledge lack Modification MOST open Open Science Framework outcome OVID problem PROSPERO protocol receiving Registered Registration Regulatory Repurposed drug repurposing repurposing. Research Research design resource risk screened Source Support systematic review Therapies therapy Transparency treat Trial Web of Science [DOI] 10.1186/s12913-022-08272-z PMC 바로가기 [Article Type] Article
Biflavonoids from Rhus succedanea as probable natural inhibitors against SARS-CoV-2: a molecular docking and molecular dynamics approachSARS-CoV-2에 대한 가능한 천연 억제제로서의 Rhus succedanea의 비플라보노이드: 분자 도킹 및 분자 역학 접근Article Published on 2022-07-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] COVID19(2023년), SARS, 치료제, [키워드] affinity Antiviral antiviral activity approach Biflavonoid biflavonoids binding affinities binding affinity binding mode binding modes binding site Bioflavonoid catalytic catalytic site complexes Compound conformational coronavirus COVID-19 drug Drug development drugs effective vaccine Effective vaccines enzyme fluctuations highlight human population hydrophilic hydrophobic in viral in vitro in vivo inhibitor initial Interaction less molecular molecular docking molecular dynamic simulation molecular dynamic simulations molecular dynamics Molecular dynamics simulation molecular dynamics simulation. molecular interaction MPro Mpro protein outbreak Panic protease provide Replication reported researcher residues Rhus Rhus succedanea RNA viruses Safe SARS-CoV-2 SARS-CoV-2 Mpro therapeutic threat unavailability viral replication virus worldwide pandemic [DOI] 10.1080/07391102.2020.1858165 PMC 바로가기 [Article Type] Article