Reduction of hemagglutination induced by a SARS-CoV-2 spike protein fragment using an amyloid-binding benzothiazole amphiphileArticle Published on 2024-05-292024-09-05 Journal: Scientific Reports [Category] update2024, [키워드] Drug discovery and development peptides Protein aggregation [DOI] 10.1038/s41598-024-59585-4 PMC 바로가기 [Article Type] Article
Transcriptomic signature, bioactivity and safety of a non-hepatotoxic analgesic generating AM404 in the midbrain PAG regionArticle Published on 2024-05-152024-09-05 Journal: Scientific Reports [Category] update2024, [키워드] CNS Drug discovery Drug discovery and development Liver toxicity Non-opioid phase 1 trial scRNA-seq [DOI] 10.1038/s41598-024-61791-z PMC 바로가기 [Article Type] Article
Tribulations and future opportunities for artificial intelligence in precision medicineReview Published on 2024-04-302024-09-05 Journal: Journal of Translational Medicine [Category] update2024, [키워드] artificial intelligence deep learning Disease diagnosis Drug discovery and development Health technology assessment machine learning precision medicine prediction prevention [DOI] 10.1186/s12967-024-05067-0 PMC 바로가기 [Article Type] Review
Cheminformatics approach to identify andrographolide derivatives as dual inhibitors of methyltransferases (nsp14 and nsp16) of SARS-CoV-2Article Published on 2024-04-292024-09-05 Journal: Scientific Reports [Category] update2024, [키워드] andrographolide Cheminformatics COVID-19 Drug discovery Drug discovery and development natural compounds nsp14 nsp16 Screening [DOI] 10.1038/s41598-024-58532-7 PMC 바로가기 [Article Type] Article
Targeted small molecule inhibitors blocking the cytolytic effects of pneumolysin and homologous toxinsArticle Published on 2024-04-262024-09-05 Journal: Nature Communications [Category] update2024, [키워드] Cryoelectron tomography Drug discovery and development Target validation Virtual drug screening [DOI] 10.1038/s41467-024-47741-3 PMC 바로가기 [Article Type] Article
Targeting the receptor binding domain and heparan sulfate binding for antiviral drug development against SARS-CoV-2 variantsArticle Published on 2024-02-022024-09-05 Journal: Scientific Reports [Category] update2024, [키워드] Computational biology and bioinformatics Drug discovery Drug discovery and development Infectious diseases [DOI] 10.1038/s41598-024-53111-2 PMC 바로가기 [Article Type] Article
Peptidyl nitroalkene inhibitors of main protease rationalized by computational and crystallographic investigations as antivirals against SARS-CoV-2Article Published on 2024-01-182024-09-05 Journal: Communications Chemistry [Category] update2024, [키워드] Computational chemistry Drug discovery and development Proteases [DOI] 10.1038/s42004-024-01104-7 PMC 바로가기 [Article Type] Article
A comprehensive review of discovery and development of drugs discovered from 2020–2022Article Published on 2023-12-102024-09-05 Journal: Saudi Pharmaceutical Journal : SPJ [Category] update2024, [키워드] CADD Characterize Clinical candidates Drug discovery and development NMEs Unmet medical needs [DOI] 10.1016/j.jsps.2023.101913 PMC 바로가기 [Article Type] Article
DNA-encoded chemical libraries yield non-covalent and non-peptidic SARS-CoV-2 main protease inhibitorsarticle Published on 2023-08-042024-09-05 Journal: Communications Chemistry [Category] update2024, [키워드] Chemical libraries Drug discovery and development Screening [DOI] 10.1038/s42004-023-00961-y PMC 바로가기 [Article Type] article
Repurposing and computational design of PARP inhibitors as SARS-CoV-2 inhibitorsarticle Published on 2023-06-292024-09-05 Journal: Burma Med J [Category] update2024, [키워드] Drug discovery and development Virtual drug screening [DOI] 10.1038/s41598-023-36342-7 PMC 바로가기 [Article Type] article