Promotion of maturation of human pluripotent stem cell-derived cardiomyocytes via treatment with the peroxisome proliferator-activated receptor alpha agonist FenofibratePluripotent Stem Cells Published on 2024-08-302024-09-05 Journal: Stem cells translational medicine [Category] update2024, [키워드] drug response Fenofibrate field potential human pluripotent stem cell-derived cardiomyocytes maturation PPARα [DOI] 10.1093/stcltm/szae029 PMC 바로가기 [Article Type] Pluripotent Stem Cells
Current Uses of Bromelain in Children: A Narrative ReviewReview Published on 2024-03-212024-09-05 Journal: Children [Category] update2024, [키워드] Ananas comosus Biomarkers Bromelain children drug response nutraceuticals pineapple therapeutic effects [DOI] 10.3390/children11030377 PMC 바로가기 [Article Type] Review
Recent advancements in single-cell metabolic analysis for pharmacological researcharticle Published on 2023-08-232024-09-05 Journal: Journal of Pharmaceutical Analysis [Category] update2024, [키워드] drug response metabolism Microfluidics Pharmacology single-cell [DOI] 10.1016/j.jpha.2023.08.014 PMC 바로가기 [Article Type] article
Machine learning approaches to predict drug efficacy and toxicity in oncologyPerspective Published on 2023-02-212024-09-05 Journal: Cell Reports Methods [Category] update2024, [키워드] artificial intelligence Drug discovery drug response machine learning [DOI] 10.1016/j.crmeth.2023.100413 PMC 바로가기 [Article Type] Perspective
Comparison of viral propagation and drug response among SARS-CoV-2 VOCs using replicons capable of recapitulating virion assembly and releaseArticle Published on 2022-10-012022-11-15 Journal: Virologica Sinica [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] acute respiratory syndrome assays Beta changed coronavirus Delta delta VoCs drug resistance drug response ENhance Evolution of SARS-CoV-2 genomes immune evasion inhibitor manifested Mutation novel antiviral drugs Protein provide quantification released remained Remdesivir replicon RNA S gene SARS-CoV-2 sgRNA supernatant Support Transcription variants variants of concern variants of concern (VOC) viral genome replication viral infectivity viral life cycle viral propagation Viral protein Viral-like particle (VLP). viral-like particles virion assembly VLP VoC VOCs WIV04 strain [DOI] 10.1016/j.virs.2022.06.008 PMC 바로가기
Anti-tuberculosis treatment strategies and drug development: challenges and priorities Reviews Published on 2022-04-272022-10-05 Journal: Nature reviews. Microbiology [Category] 바이오마커, 진단, [키워드] accelerate animal model benefit Characteristics clinical trial clinically disease severity drug candidate Drug discovery drug response exceptional highlight Host in vitro tool Infection inherent marker MOST organizations pathogen predictor progression pulmonary disease regimen regimens Research review synergy therapy translate Treatment treatment strategy Trial tuberculosis disease [DOI] 10.1038/s41579-022-00731-y [Article Type] Reviews
Potential Role of Selenium in the Treatment of Cancer and Viral InfectionsReview Published on 2022-02-172022-10-29 Journal: International Journal of Molecular Sciences [Category] Coronavirus, COVID19(2023년), MERS, SARS, [키워드] addition association Blood Cancer Chemotherapy clinically Combination dose doses drug resistance drug response evaluated metabolite pathway patients with COVID-19 Potential role Selenium survival therapeutic therapeutic target Treatment Vaccine viral infection [DOI] 10.3390/ijms23042215 PMC 바로가기 [Article Type] Review
Exploring AyuGenomics approach for understanding COVID-19 predisposition and progressionReview article Published on 2022-01-012022-10-05 Journal: Journal of Ayurveda and Integrative Medicine [Category] 신약개발, 유전자 메커니즘, [키워드] allele Antigen approach AyuGenomics Ayurveda clinical evaluation clinically COVID-19 COVID-19 infection described drug response enzyme Genes Genetic Genetic predisposition Genetic variant genomic Genomics HLA HLA-DR hypothese identifying immune response imperative individual integrative medicine leukocyte management offer Personalized medicine phenotype phenotypic phenotypic variant populations predict predisposition progression protease recent reported SARS-CoV-2 serine 2 susceptibility tested Therapeutic strategies transmembrane variant variations [DOI] 10.1016/j.jaim.2021.06.003 [Article Type] Review article
Jumper enables discontinuous transcript assembly in coronaviruses점퍼는 코로나바이러스에서 불연속 전사 조립을 가능하게 합니다.Article Published on 2021-11-182022-09-10 Journal: Nature Communications [Category] MERS, SARS, 유전자 메커니즘, 치료제, [키워드] alignment analyses Analysis assembly canonical classical conditions coronavirus develop discontinuous transcription drug response eukaryote eukaryotes expressed expression Gene Expression Genome informatics identify JUMPER likelihood MERS-CoV Nidovirale Nidovirales outperform predict produced reveal RNA polymerase RNA splicing RNA-dependent RNA polymerase SARS-CoV-1 SARS-CoV-2 Software subsequent supported transcript transcriptional change Transcriptional changes Transcriptome transcriptomes transcripts Treatment Viral Viral RNA viral RNA-dependent RNA polymerase virus viruses [DOI] 10.1038/s41467-021-26944-y PMC 바로가기 [Article Type] Article
Chemogenomic Fingerprints Associated with Stage-Specific Gametocytocidal Compound Action against Human Malaria ParasitesArticle Published on 2021-10-082024-08-28 Journal: ACS Infectious Diseases [Category] 말라리아, [키워드] chemogenomic drug response gametocyte kinase Plasmodium stage-specific.