Brequinar and dipyridamole in combination exhibits synergistic antiviral activity against SARS-CoV-2 in vitro: Rationale for a host-acting antiviral treatment strategy for COVID-19Research article Published on 2022-10-012022-10-05 Journal: Antiviral Research [Category] COVID19(2023년), SARS, 변종, 치료법, 치료제, [키워드] acute respiratory syndrome Antiviral antiviral activity Antiviral treatment B.1.351 B.1.617.2 Beta Brequinar cellular Combination coronavirus coronavirus disease COVID-19 de novo deaths Delta DHODH Dihydroorotate dehydrogenase (DHODH) Dipyridamole drug treatments effective enzyme evade Evolution of SARS-CoV-2 exhibit global pandemic Host host cell in vitro Infection infections inhibitor maintain medical need monoclonal antibody nucleotide pathway rationale Replication required resulting RNA virus SARS-CoV-2 SARS-COV-2 infection selective shown Support synergistic therapy treat Treatment Vaccine variants viral replication [DOI] 10.1016/j.antiviral.2022.105403 [Article Type] Research article
Investigating and Resolving Cardiotoxicity Induced by COVID-19 Treatments using Human Pluripotent Stem Cell-Derived Cardiomyocytes and Engineered Heart TissuesArticle Published on 2022-10-012022-11-15 Journal: Advanced Science [Category] 신약개발, 치료제, [키워드] antiviral drugs approved drugs ATP2A2 cardiotoxic effect Cardiotoxicity cell death Clinical data clinical trial clinically concentrations contractile Coronavirus disease 2019 COVID-19 demonstrated drug drug candidate drug treatments dysregulation effective engineered heart tissue evaluate expression of gene fumarate handling HCN4 heart heart tissue High Throughput Screening Human human pluripotent stem cell-derived cardiomyocytes induced ion homeostasis limit MYH6 Patient powerful tool regulate Remdesivir Repurposed drug repurposed drugs for COVID-19. reveal Ritonavir RNA-seq analysis significantly Spread STEM therapy TNNT2 [DOI] 10.1002/advs.202203388 PMC 바로가기
Network approaches for modeling the effect of drugs and diseases약물 및 질병의 영향 모델링을 위한 네트워크 접근 방식Review Published on 2022-07-182022-09-11 Journal: Briefings in Bioinformatics [Category] COVID19(2023년), SARS, 신약개발, [키워드] adverse effects Algorithm approach biological networks biological response Chronic diseases Compound computational method Computational methods COVID-19 disease disease modeling Diseases drug drug combination drug combinations drug target drug treatments drug’s MOA drugs explain FDA-approved drug generate IMPROVE in silico induce mechanism mechanism of action network network analysis omics technologies Perturbation perturbations SARS-COV-2 infection SARS-CoV-2 infections Stage study drug Support targets therapeutic effect These data to define Treatment [DOI] 10.1093/bib/bbac229 PMC 바로가기 [Article Type] Review
A multilevel approach for screening natural compounds as an antiviral agent for COVID-19COVID-19에 대한 항바이러스제로서 천연 화합물을 스크리닝하기 위한 다단계 접근법Article Published on 2022-06-012022-09-11 Journal: Computational biology and chemistry [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] analyses Analysis analyzed Antiviral approach attachment AutoDock vina Cluster analyses Compound computer-aided drug design COVID-19 database DFT disrupt docked docking domain drug drug design drug treatments drug-likeness effort exploratory Frame high-affinity binding host cell host cells identify inhibitor inhibitors Interaction ligands machine learning approach machine learning approaches Prevent Principal component principal component analysis protein-ligand interaction protocol RBD RBD domain RBD region SARS-CoV-2 spike receptor-binding domain Spread the RBD therapeutic agent was performed [DOI] 10.1016/j.compbiolchem.2022.107694 PMC 바로가기 [Article Type] Article
Pregnancy and COVID-19, focus on vaccine and pharmacological treatment임신과 코로나19, 백신과 약리치료에 집중Review Published on 2022-06-012022-09-11 Journal: Journal of reproductive immunology [Category] 변종, 임상, 치료법, 치료제, [키워드] change clinical clinical evidence clinical trials Comorbidities compassionate use Complication complications COVID-19 COVID-19 disease COVID-19 mRNA vaccine COVID-19 mRNA vaccines drug treatments drugs during pregnancy Evidence excluded global pandemic group highlighting immune increased risk indicate individual Infants Infection knowledge limit mother off-label pharmacological treatment population groups Pregnancy pregnancy complications pregnant women progression recommendation Respiratory system Spread therapy vaccination Vaccine variant variants virus women [DOI] 10.1016/j.jri.2022.103630 PMC 바로가기 [Article Type] Review
The impact of COVID-19 on pregnancy and therapeutic drug development코로나19가 임신과 치료제 개발에 미치는 영향Review Published on 2022-05-012022-09-11 Journal: British Journal of Pharmacology [Category] 신약개발, [키워드] age anniversary approach article baby benefit cardiovascular disease cardiovascular diseases clinical study clinical trial clinical trials Community COVID COVID-19 COVID-19 mRNA vaccine COVID-19 mRNA vaccines disorder disorders Drug development drug treatment drug treatments during pregnancy eclampsia Effect generate Healthcare provider healthcare providers Humoral immunity hypertensive Hypothesis knowledge lactating women life management mother offer offered outcome pre-eclampsia Pregnancy pregnant pregnant women risk robust second wave significantly higher subsequent supported therapeutic drug Trial vaccination Vaccine Vaccines with COVID-19 women [DOI] 10.1111/bph.15582 PMC 바로가기 [Article Type] Review
COVID-19 therapeutics: Challenges and directions for the futureCOVID-19 치료제: 미래를 위한 도전과 방향Review Published on 2022-04-122022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), SARS, 신약개발, [키워드] approach benefit challenge clinical trial country COVID-19 COVID-19 pandemic disease drug Drug development drug treatment drug treatments Effective vaccines Epidemiology facilitated Factor Health immunology in viral medical emergency pandemic Planning risk SARS-CoV-2 Sequencing Support triggering Virology [DOI] 10.1073/pnas.2119893119 PMC 바로가기 [Article Type] Review
Systematic identification of ACE2 expression modulators reveals cardiomyopathy as a risk factor for mortality in COVID-19 patientsACE2 발현 조절제의 체계적인 식별은 심근병증을 COVID-19 환자의 사망 위험 인자로 밝혀줍니다Research Published on 2022-01-102022-09-11 Journal: Genome Biology [Category] 유전자 메커니즘, [키워드] ACE2 ACE2 expression Analysis angiotensin angiotensin-converting enzyme 2 Cardiomyopathy cardiovascular conditions categories characterized Comprehensive condition COVID-19 illness COVID-19 patient COVID-19 patients Critical dataset datasets develop disease drug drug treatment drug treatments drugs Electronic health record Electronic health records enzyme expression Genetic healthy heart HNF1A human tissue identify increased mortality Infection itraconazole joint Mortality overexpression Pathogenesis pathogenesis of COVID-19 Patient perturbations RAD140 receptor Result reveal risk risk factor Risk factors RNA-Seq SARS-CoV-2 SARS-COV-2 infection Seven severe COVID-19 illness supplementary material Transmission upregulation variance while [DOI] 10.1186/s13059-021-02589-4 PMC 바로가기 [Article Type] Research
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Patients사설: 입원하지 않은 환자의 SARS-CoV-2 감염에 대한 경구용 항바이러스제 치료 현황Editorial Published on 2022-01-012022-09-11 Journal: Medical science monitor : international medical jo [Category] SARS, 변종, 신약개발, 진단, 치료제, [키워드] administration antiviral drug antiviral drug treatment antiviral drugs approval approved bamlanivimab can be used Casirivimab children Community community setting costly COVID-19 current drug drug treatments early stage early stages editorial effective Emergency use authorization etesevimab EUA FDA healthcare facility Healthcare Products Regulatory Agency Hospitalization Imdevimab increased risk intravenous Intravenous administration Medicine Medicines MHRA Mild Moderate COVID-19 molnupiravir neutralizing monoclonal antibodies Nirmatrelvir oral Paxlovid positive priority product progression Regulatory Remdesivir Ritonavir SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 test SARS-CoV-2 virus severe COVID-19 status the SARS-CoV-2 virus therapeutic Treatment variants of concern [DOI] 10.12659/MSM.935952 PMC 바로가기 [Article Type] Editorial
Therapeutic potential of melatonin and melatonergic drugs on K18-hACE2 mice infected with SARS-CoV-2SARS-CoV-2에 감염된 K18-hACE2 마우스에 대한 멜라토닌 및 멜라토닌성 약물의 치료 가능성Article Published on 2022-01-012022-09-11 Journal: Journal of pineal research [Category] SARS, 변종, 신약개발, [키워드] administration agomelatine benefit candidate changes in Clinical outcome clinical trials Compound COVID-19 COVID-19 pandemic COVID-19 pathogenesis Cytokines Daily disease dose drug Drug repurposing drug treatment drug treatments drugs effective exacerbated expressing hACE2 human ACE2 receptor humans infected with SARS-CoV-2 Infection Inflammatory cytokine Inflammatory cytokines interferons K18-hACE2 K18-hACE2 mice limit Local lung melatonin mice Occurrence preclinical study Prophylactic ramelteon ramelteon. Safe SARS-CoV-2 SARS-COV-2 infection shown Spread survival susceptible Symptom tested therapeutic therapeutic potential treat treated Treatment type I type I and type III interferons type III Type III interferons vaccination variant [DOI] 10.1111/jpi.12772 PMC 바로가기 [Article Type] Article