Dry Powder Inhaler Formulation of Lactobacillus rhamnosus GG Targeting Pseudomonas aeruginosa Infection in Bronchiectasis Maintenance TherapyArticle Published on 2024-07-252024-09-05 Journal: Pharmaceutics [Category] update2024, [키워드] Dry powder inhaler Lung infection Probiotics pulmonary drug delivery [DOI] 10.3390/pharmaceutics16080980 PMC 바로가기 [Article Type] Article
Inhalation of vaccines and antiviral drugs to fight respiratory virus infections: reasons to prioritize the pulmonary route of administrationarticle Published on 2023-09-282024-09-05 Journal: mBio [Category] update2024, [키워드] Aerosols Antiviral agents dry powder formulation Dry powder inhaler IgA inhalation mucosal immunity Pulmonary administration respiratory viruses SARS-CoV-2 Spray drying Vaccines [DOI] 10.1128/mbio.01295-23 PMC 바로가기 [Article Type] article
Inhaled antibodies: Quality and performance considerations흡입 항체: 품질 및 성능 고려 사항Review Published on 2022-04-292022-09-12 Journal: Human vaccines & immunotherapeutics [Category] MERS, 진단, [키워드] administration Aerosols amplify antibodies antibody Asthma COVID-19 dosage drug Dry powder inhaler Formulation Infectious disease involved Local Lung disease Lungs Measures molecular nebulizer offer Protein Quality receptor specificity stability target the disease Therapeutics therapy Treatment variety virus [DOI] 10.1080/21645515.2021.1940650 PMC 바로가기 [Article Type] Review
Co-Spray Dried Nafamostat Mesylate with Lecithin and Mannitol as Respirable Microparticles for Targeted Pulmonary Delivery: Pharmacokinetics and Lung Distribution in RatsArticle Published on 2021-09-192022-10-28 Journal: Pharmaceutics [Category] COVID-19, [키워드] acute respiratory syndrome Administered administration Analysis blood plasma Bronchoalveolar lavage fluid caused co-spray coronavirus Coronavirus disease 2019 COVID-19 distribution Dry powder inhaler Ex vivo in vitro in vivo inhibitor intratracheal administration intravenous lecithin lung lung tissue mannitol mesylate Microparticle nafamostat Nafamostat mesylate new strain pharmacokinetics pulmonary RAT respiratory tract SARS-CoV-2 SARS-CoV-2 S spray stability suppresse tissue transmembrane serine protease [DOI] 10.3390/pharmaceutics13091519 PMC 바로가기 [Article Type] Article
Niclosamide inhalation powder made by thin-film freezing: Multi-dose tolerability and exposure in rats and pharmacokinetics in hamsters박막 동결로 만든 니클로사미드 흡입 분말: 쥐의 다중 용량 내약성 및 노출 및 햄스터의 약동학Article Published on 2021-06-152022-09-12 Journal: International journal of pharmaceutics [Category] MERS, SARS, 진단, [키워드] Administered administration Antiviral approved Concentration demonstrated develop drug candidate Dry Dry powder inhaler evidenced exhibited film fraction freezing geometric GSD hamster histopathology analysis Infection lung Lung pharmacokinetics Lungs median medication MMAD niclosamide oral bioavailability overcome pharmacological primary site pulmonary Pulmonary administration required Safe SARS-CoV-2 SARS-COV-2 infection Standard deviation tested Thin Thin Film Freezing. Tolerability was used [DOI] 10.1016/j.ijpharm.2021.120701 PMC 바로가기 [Article Type] Article
Development and evaluation of inhalable composite niclosamide-lysozyme particles: A broad-spectrum, patient-adaptable treatment for coronavirus infections and sequalae흡입 가능한 복합 니클로사미드-리소자임 입자의 개발 및 평가: 코로나바이러스 감염 및 후유증에 대한 광범위한 스펙트럼, 환자 적응형 치료제Research Article Published on 2021-02-112022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, [키워드] acquisition administration alternative antiviral efficacy approach causative agent clinical development coronavirus Coronavirus infection coronavirus strains COVID-19 pandemic demonstrated development drug drug level Dry powder inhaler endogenous protein Formulation hLYS human lysozyme Hypothesis in vitro in vivo inflammatory lung damage lower airway lung damage MERS MERS-CoV methicillin methicillin-resistance staphylococcus aureus pneumonia nasal Nasal spray nebulizer NIC niclosamide offer Particle Pneumonia primary site Protein respiratory respiratory tract SARS-CoV-2 SARS-CoV-2 infections secondary to Spread Stage Staphylococcus aureus the disease treating COVID-19 Treatment upper and lower airways [DOI] 10.1371/journal.pone.0246803 PMC 바로가기 [Article Type] Research Article
Development of Remdesivir as a Dry Powder for Inhalation by Thin Film FreezingArticle Published on 2020-10-222022-10-28 Journal: Pharmaceutics [Category] COVID-19, [키워드] absorbed affected aggregate antiviral therapy approval brittle matrix powder circulation Course COVID-19 demonstrated development Dry dry powder for inhalation Dry powder inhaler effective Emergency use exhibit exhibited film freezing greater GS-441524 hydrolyzed in vitro activity in vivo inhalation leucine low-density lung Lungs median Microparticle morbidity and mortality patients with COVID-19 pharmacokinetic powder reduce Remdesivir SARS-CoV-2 the disease Thin thin film freezing treat [DOI] 10.3390/pharmaceutics12111002 PMC 바로가기 [Article Type] Article
Optimization of a dry powder inhaler of ciprofloxacin-loaded polymeric nanomicelles by spray drying processarticle Published on 2019-06-302024-09-01 Journal: Pharmaceutical Development and Technology [Category] 폐렴구균 감염증, [키워드] ciprofloxacin Dry powder inhaler nanoaggregate optimization polymeric nanomicelle Spray drying [Article Type] article