Comparison of SARS-CoV-2 variants of concern in primary human nasal cultures demonstrates Delta as most cytopathic and Omicron as fastest replicatingResearch Article Published on 2024-04-132024-09-05 Journal: mBio [Category] update2024, [키워드] COVID-19 dsRNA primary nasal cultures SARS-CoV-2 spike cleavage variants of concern [DOI] 10.1128/mbio.03129-23 PMC 바로가기 [Article Type] Research Article
Knockdown of Anopheles dirus far upstream element-binding protein gene lower oocyst numbers of Plasmodium vivaxarticle Published on 2023-12-312024-09-01 Journal: Medical and Veterinary Entomology [Category] 말라리아, [키워드] Anopheles dirus dsRNA far upstream element-binding protein malaria Plasmodium vivax [Article Type] article
Comparison of SARS-CoV-2 variants of concern in primary human nasal cultures demonstrates Delta as most cytopathic and Omicron as fastest replicatingArticle Published on 2023-12-212024-09-05 Journal: bioRxiv [Category] update2024, [키워드] COVID-19 dsRNA primary nasal cultures SARS-CoV-2 spike cleavage variants of concern [DOI] 10.1101/2023.08.24.553565 PMC 바로가기 [Article Type] Article
Double-stranded RNA immunohistochemistry as a screening tool for viral encephalitisOriginal Article Published on 2023-08-042024-09-05 Journal: Nuklearmedizin [Category] update2024, [키워드] dsRNA metagenomic sequencing viral encephalitis [DOI] 10.1093/ajcp/aqad039 PMC 바로가기 [Article Type] Original Article
Engineered Gut Symbiotic Bacterium-Mediated RNAi for Effective Control of Anopheles Mosquito Larvae엔지니어링된 장내 공생 세균 매개 RNAi를 통한 안opheles 모기 유충의 효과적인 제어Article Published on 2023-07-172024-08-01 Journal: Microbiology Spectrum [Category] 말라리아, [키워드] dsRNA gut symbiotic bacterium Mosquito RNase III symbiont-mediated RNAi [DOI] 10.1128/spectrum.01666-23 PMC 바로가기
C57Bl/6N mice have an attenuated lung inflammatory response to dsRNA compared to C57Bl/6J and BALB/c micearticle Published on 2023-02-212024-09-05 Journal: Journal of Inflammation (London, England) [Category] update2024, [키워드] BALB/c C57BL/6J C57Bl/6N dsRNA Inflammation lung Mouse models poly(I:C) respiratory viral infection [DOI] 10.1186/s12950-023-00331-4 PMC 바로가기 [Article Type] article
Virtual Screening and Quantum Chemistry Analysis for SARS-CoV-2 RNA-Dependent RNA Polymerase Using the ChEMBL Database: Reproduction of the Remdesivir-RTP and Favipiravir-RTP Binding Modes Obtained from Cryo-EM Experiments with High Binding AffinityArticle Published on 2022-09-202022-11-15 Journal: International Journal of Molecular Sciences [Category] SARS, 신약개발, 치료법, 치료제, [키워드] acute respiratory syndrome adopted affinity Analysis anti-SARS-CoV-2 anti-viral activity approved binding affinity binding free energy ChEMBL Chemistry clinical development Compound coronavirus coronavirus disease COVID-19 Cryo-electron microscopy cryo-EM cryo-EM structure database docking drug drug candidates drug library drug repositioning drugs dsRNA fragment molecular orbital calculation Frequency frequency analysis interactions mode molecular Novel coronavirus ONIOM geometry optimization calculation pathogenic PDB performed predicted quantum quantum chemistry calculation RdRP reported reproduction RNA RNA-dependent RNA polymerase SARS-CoV-2 Screening screenings significantly suggested Treatment Virtual screening was performed [DOI] 10.3390/ijms231911009 PMC 바로가기
Viral cross-class transmission results in disease of a phytopathogenic fungus Research Published on 2022-08-312022-10-05 Journal: The ISME Journal [Category] 유전자 메커니즘, [키워드] Asymptomatic B. cinerea Botrytis cinerea Brassica carried change characterized Contact Cross-species transmission described disease dsRNA Efficiency fungal fungi groups growth Implications Infection isolate mycelial no significant difference occur pathogen pathogenicity phenotypical plant provide RNA RNA sequencing spore Strains Transmission transmitted vectors virus [DOI] 10.1038/s41396-022-01310-y [Article Type] Research
Expression Profile and Localization of SARS-CoV-2 Nonstructural Replicase Proteins in Infected CellsArticle Published on 2022-08-312022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, 치료기술, 치료법, [키워드] acute respiratory syndrome analyzed antibody antiviral strategy caused coronavirus COVID-19 pandemic determine diagnosis of SARS-CoV-2 diagnostics different time points diffusion dsRNA expression expression profile foci function Gene Expression immunofluorescence assay indicated Infection Localization mechanism mechanisms N protein nonstructural protein nsp13 nsp14 Nsp15 NSP2 Nsp3 Nsp9 Postinfection potential molecular profile Protein protein-protein interaction Proteins provide regulated replicase replicase proteins Replication responsible SARS-CoV-2 SARS-CoV-2-infected cell subcellular distribution subcellular localization suggested viral growth virus replication [DOI] 10.1128/spectrum.00744-22 PMC 바로가기
The intersection molecule MDA5 in Cancer and COVID-19Article Published on 2022-08-312022-11-15 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, 치료법, 치료제, [키워드] anti-tumor immunity antiviral response Autoimmune diseases cancer cell cGAS-STING connection COVID-19 cytoplasmic damaged dead Defense dsRNA evade function Host IFN immunomodulatory factor induce Inflammatory cytokines innate immune responses innate immune system interferon Intersection MDA5 mechanism Melanoma nucleic acid PAMPs pathogen-associated molecular pattern pattern recognition receptor Pattern recognition receptors pattern recognition receptors. PRRs recognizing RNA SARS-CoV-2 SARS-CoV-2 virus infection signaling pathway subsequent Trigger triggering Viral RNA virus [DOI] 10.3389/fimmu.2022.963051 PMC 바로가기