Modeling the Enzymatic Mechanism of the SARS-CoV-2 RNA-Dependent RNA Polymerase by DFT/MM-MD: An Unusual Active Site Leading to High Replication RatesArticle Published on 2022-09-122022-11-15 Journal: Journal of Chemical Information and Modeling [Category] SARS, 유전자 메커니즘, 치료제, [키워드] absence Activation Antiviral assist cellular compensated computation COVID-19 diffusion duplication Efficiency Enzymes highlight histidine Inclusion infecting Infection lack leading less Lower lysine mechanism modeling nucleotide Pandemics performed polymerase polymerases Rate reactive reactivity Replication replication of SARS-CoV-2 RNA RNA genome RNA viruses RNA-dependent RNA polymerase SARS-CoV-2 genome Site subsequent the SARS-CoV-2 viral genome Viral RNA virus [DOI] 10.1021/acs.jcim.2c00802 PMC 바로가기
Recruitment of pregnant women to randomised trials of COVID 19 treatments, and pharmaceutical treatments received outside such trials: A research articleCOVID 19 치료법의 무작위 시험에 임산부 모집 및 그러한 시험 이외의 약물 치료: 연구 기사Article Published on 2022-08-012022-09-11 Journal: European journal of obstetrics, gynecology, and re [Category] 임상, 치료법, 치료제, [키워드] Administered administration Case report case reports Case series case sery clinical trial registry controlled trials COVID 19 COVID-19 COVID-19 pandemic de-duplication duplication early phase eligible enrolled excluded identify information NIH observational studies participated Pregnancy pregnant women randomised Randomised trial randomised trials Randomized controlled trials recommendations registries reported Research searched Seven systematic review Treatment Trial trials with COVID-19 women [DOI] 10.1016/j.ejogrb.2022.05.009 PMC 바로가기 [Article Type] Article
Chromosome-level and haplotype-resolved genome provides insight into the tetraploid hybrid origin of patchouli Research Published on 2022-06-182022-10-05 Journal: Nature Communications [Category] 변종, 유전자 메커니즘, [키워드] Bioactivity biosynthetic gene chromosome components determine duplication Genome genomic identify occurred offer Patchouli Pogostemon provide Research resource reveal whole genome [DOI] 10.1038/s41467-022-31121-w [Article Type] Research
Most published systematic reviews of remdesivir for COVID-19 were redundant and lacked currencyResearch article Published on 2022-06-012022-10-05 Journal: Journal of clinical epidemiology [Category] 임상, [키워드] approach clinical Completeness COVID-19 cross-sectional duplication Europe Inclusion Living evidence median MOST objective PMC PROSPERO provided randomized trial Registered Remdesivir Result searched setting survival systematic review systematic reviews trials [DOI] 10.1016/j.jclinepi.2022.02.006 [Article Type] Research article
Virtual screening of approved clinic drugs with main protease (3CL pro) reveals potential inhibitory effects on SARS-CoV-2주요 프로테아제 (3CL PRO)가있는 승인 된 클리닉 약물의 가상 스크리닝Article Published on 2022-02-012022-08-31 Journal: Journal of biomolecular structure & dynamics [Category] COVID19(2023년), MERS, SARS, 치료제, [키워드] 3CL 3CL pro 3CLpro active sites approved approved drugs Capastat Carfilzomib drug drug library duplication high affinity inhibit inhibitory effect molecular molecular dynamics Molecular dynamics simulation Novel coronavirus protease responsible reveal saquinavir SARS-CoV-2 tested Treatment treatment of COVID-19 Viomycin Virtual screening [DOI] 10.1080/07391102.2020.1817786 PMC 바로가기 [Article Type] Article
Extensive progressive heterotopic ossification post-Covid-19 in a man남성의 코로나19 이후 광범위한 진행성 이소성 골화Case Reports Published on 2022-02-012022-09-11 Journal: Bone [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] ACVR1 affecting association Atypical Brain cause characteristic characterized classic Clinical severity Clinical significance coding region coding regions congenital malformation COVID-19 Deletion deletions disorder duplication duplications elbows exonic regions Extensive fascia fibrodysplasia ossificans progressiva form Genetic great toe Hallux valgus healthy Heterotopic ossification include Infection Local mechanism muscle reported SARS-CoV-2 SARS-COV-2 infection severe SARS severe SARS-CoV-2 skeletal skeletal muscles Soft tissue soft tissues spinal cord suffered surgery swelling systemic inflammation trauma variant [DOI] 10.1016/j.bone.2021.116287 PMC 바로가기 [Article Type] Case Reports
Acute Mesenteric Ischemia in COVID-19 PatientsReview Published on 2021-12-302022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] Acute mesenteric ischemia adjust affected anticoagulant therapy Artery article association bowel C reactive protein COVID-19 COVID-19 patients CRP Cytokines duplication Endothelitis feature Fluid management help Hospitalized hospitalized COVID-19 patients hypercoagulability ICU Patients information intestinal involved Ischemia Laboratory Leukocytosis management mechanism Mesenteric Microvascular thrombosis offer outcome Pathways patients reported risk factor SARS-CoV-2 SARS-COV-2 infection surgery thromboemboembolism Thromboembolism Thromboprophylaxis understanding Vascular viability was performed Web of Science [DOI] 10.3390/jcm11010200 PMC 바로가기 [Article Type] Review
Template switching and duplications in SARS-CoV-2 genomes give rise to insertion variants that merit monitoringArticle Published on 2021-11-302022-10-31 Journal: Communications Biology [Category] COVID-19, SARS, [키워드] Affect Analysis antigenic B.1.1.7 B.1.351 B.1.617.2 consensus genome Course COVID-19 pandemic Deletion duplication Effect escaped Evidence furin site Genome informatics genomes higher infectivity identify insertion mechanism N-terminal domain Neutralizing antibodies new SARS-CoV-2 nucleotide substitution pandemic pathogenicity polymerase predicted Protein researcher SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 variants Sequencing subgenomic RNAs switching T-cell immunity Template the S protein the SARS-CoV-2 the Spike thought unique variant variants virulence virus [DOI] 10.1038/s42003-021-02858-9 PMC 바로가기 [Article Type] Article
Dynamic genome plasticity during unisexual reproduction in the human fungal pathogen Cryptococcus deneoformans인간 곰팡이 병원체 암호화 코커스 데네 노모 인에서의 단성 재생산 동안의 동적 게놈 소성Research Article Published on 2021-11-292022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adaptation addition Aneuploidy azole Cancer Cell cell cycle cell-cell fusion cells characterization characterized chromosome chromosomes concert conditions contributed copy number Critical Cryptococcus Cryptococcus neoforman Cryptococcus neoformans cyclin cyclins defect detect differentially expressed diploid duplication dynamic early phase eukaryotic events Evidence evidence of Evolution example form fungal fungi generate genes encoding Genetic Genome hallmark haploid Host host infection Implications in some increase independent instance intrinsic isolates kinase kinases lead maintain maintenance mechanism meiosis meiotic mitotic molecular mechanism molecular mechanisms nourseothricin nuclear nuclear fusion occur organism Organisms pathogen pathway plasticity ploidy polyploid public health Regulatory reporter serotype sexual development survival uracil VAR Variation [DOI] 10.1371/journal.pgen.1009935 PMC 바로가기 [Article Type] Research Article
Gilteritinib for Relapsed Acute Myeloid Leukaemia with FLT3 Mutation during the COVID-19 Pandemic: Real World Experience from the UK National Health ServiceConference abstract Published on 2021-11-232022-10-05 Journal: Blood [Category] 변종, [키워드] 95%CI Administered Allogeneic AML approved ASXL1 board Cell Chemotherapy clinically clinician collected Complete COVID-19 COVID-19 pandemic criteria curative database de novo disease domain dose download duplication education effective ELN European experience figure FLT3 Follow-up funding Gilteritinib haematological disorder healthcare hospital Hospital admission IDH1 IDH2 immunosuppressive infected with SARS-CoV-2 information inhibitor Intensive Jazz less majority male median median age Morphological Mortality Most patient mutated Mutation mutations myeloid National Health Service network neutropenia NHS nosocomial not differ NPM1 outcome pandemic Patient patients performance status Physicians proceed reached reducing Registered reported resource resources response Result risk RUNX1 Sequencing significantly speaker Support survival Takeda the median therapy Toxicity TP53 Transmission Treatment tyrosine United Kingdom [DOI] 10.1182/blood-2021-150169 [Article Type] Conference abstract