Structural insight into the recognition of the linear ubiquitin assembly complex by Shigella E3 ligase IpaH1.4/2.5Shigella E3 리가제 IpaH1.4/2.5에 의한 선형 유비퀴틴 조립 복합체 인식에 대한 구조적 통찰Article Published on 2023-03-312024-08-22 Journal: Disaster Medicine and Public Health Preparedness [Category] 세균성이질, [키워드] crystal structure effector Shigella flexneri ubiquitin ligase.
Central and effector memory T cells in peripheral blood of patients with interstitial pneumonia: preliminary clues from a COVID-19 studyArticle Published on 2022-10-102022-11-15 Journal: Respiratory Research [Category] COVID19(2023년), SARS, 바이오마커, [키워드] acute phase addition affected Analysis biological marker CD3+ cells CD4 CD8 Cell cell population central memory Central memory T cells control group control patient controls COVID-19 COVID-19 diagnosis cross-sectional decrease described differential expression disease early phase effector effector memory Effector memory T cells flow cytometry group homeostasis hospital Hospital admission immune increase interstitial interstitial lung involvement interstitial pneumonia lymphocyte subpopulation Lymphocyte subpopulations memory memory T memory T cells Patient patients with pneumonia performed Peripheral blood peripheral lymphocyte Pneumonia positive pre-existing T-cell protocol reactivity recruited Research Respiratory disease SARS-CoV-2 SARS-CoV-2 PCR severe COVID-19 patients significant decrease significant increase study participant study period subpopulations subset T cell T-cell therapeutic viral respiratory infections were assessed [DOI] 10.1186/s12931-022-02190-8 PMC 바로가기
Identification of serum metabolites enhancing inflammatory responses in COVID-19Article Published on 2022-10-012022-11-15 Journal: Science China. Life sciences [Category] COVID19(2023년), SARS, 치료제, [키워드] activate Activation acute respiratory syndrome Administered agmatine alleviate Antiviral caused changed characterized circulating metabolite coronavirus Coronavirus disease 2019 COVID-19 COVID-19 infection COVID-19 patient COVID-19 patients cytokine production drug Effect effector elevated elicit embryonic exhibiting fibroblast identification IFNs IL-6 IL-6 level Inflammation Inflammatory cytokine Inflammatory response interferon regulatory factor interferons IRFs macrophages metabolite metabolites metabolites. metabolome mice molecular mechanism NF-κB NF-κB pathway Proinflammatory cytokine putrescine responsible resulting SARS-CoV-2 serum severity significantly stages strong immune response systemic inflammatory responses Tandem mass spectrometry tested the disease TNF type I interferon underlie wildtype [DOI] 10.1007/s11427-021-2099-7 PMC 바로가기
Epigenetic activation of antiviral sensors and effectors of interferon response pathways during SARS-CoV-2 infectionArticle Published on 2022-09-012022-11-15 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), SARS, 바이오마커, 진단, [키워드] Activation Affect Antiviral Biomarker blood cell change changes in Cohort coronavirus COVID-19 COVID-19 disease COVID-19 patient COVID-19 patients DNA DNA methylation effector Epigenetic epigenetics expression expression of gene Hospitalized identify Infection intensive care unit Interaction interferon response involved lesion management Methylation MOST outcomes pathology pathophysiology pathway Patient populations Potential treatment recent reported SARS-CoV-2 SARS-COV-2 infection Severity of infection shown subset Symptom Symptoms the disease transcriptomics upper respiratory tract [DOI] 10.1016/j.biopha.2022.113396 PMC 바로가기
A disturbed balance between blood complement protective factors (FH, ApoE) and common pathway effectors (C5a, TCC) in acute COVID-19 and during convalesce Research Published on 2022-08-112022-10-05 Journal: Scientific Reports [Category] SARS, 바이오마커, 치료법, [키워드] activate Activation acute COVID-19 affected Blood C-reactive protein C5a Cluster collected complement Complement activation complex conditions convalescent plasma treatment correlated COVID-19 COVID-19 patients CRP death Deep venous thrombosis demonstrated DVT effector electronic medical records element elevated event HMGB1 homeostasis IgA IgG IgM IL-6 immune response immune system immunological Immunological response incidence Increased Infection Inflammatory response investigated knowledge marker Mortality Necrosis non-specific pathway Patient patients hospitalized PCR-confirmed diagnosis protective factor RAGE remained SARS-COV-2 infection SARS-CoV-2 spike protein shown tissue Treatment viral burden Viral load was collected were assessed [DOI] 10.1038/s41598-022-17011-7 [Article Type] Research
Microbe capture by splenic macrophages triggers sepsis via T cell-death-dependent neutrophil lifespan shortening Research Published on 2022-08-092022-10-05 Journal: Nature Communications [Category] 임상, 진단, [키워드] adaptive attenuate Bacteria CD169 cytokine degrade deplete detrimental downstream effector fungi G-CSF histone hyperinflammation hyphae immature immune dysfunction Immunity induce Infection infiltration Macrophage macrophages mechanism mechanism of action microbial Mortality myeloperoxidase neutralize neutrophil oxidative burst pathogen pathology Patient patient mortality phagocytic plasma promote receptor receptors Sepsis T cell Trigger zone [DOI] 10.1038/s41467-022-32320-1 [Article Type] Research
Potent human broadly SARS-CoV-2-neutralizing IgA and IgG antibodies effective against Omicron BA.1 and BA.2Omicron BA.1 및 BA.2에 효과적인 강력한 인간 SARS-CoV-2 중화 IgA 및 IgG 항체Article Published on 2022-07-042022-09-11 Journal: The Journal of Experimental Medicine [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] animal models antibody Antibody Response Antibody responses Antiviral B-cell boost breadth candidate Cell cellular contribute convalescent COVID-19 demonstrated Diversity effective effector elicited functions Humoral immunity IgA IgA antibodies IgA antibody IgG antibodies IgG antibody immune protection memory B memory B cell memory B-cell monoclonal antibody mucosal tissue mucosal tissues Neutralizing omicron potent prevented provided Receptor-binding domain S2 subunit SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 spike protein SARS-CoV-2 variant serological severe COVID-19 Spike protein the receptor-binding domain the SARS-CoV-2 therapeutic efficacy Treatment Wuhan [DOI] 10.1084/jem.20220638 PMC 바로가기 [Article Type] Article
Mesenchymal stem cell-derived extracellular vesicles for immunomodulation and regeneration: a next generation therapeutic tool? Reviews Published on 2022-07-042022-10-05 Journal: Cell Death & Disease [Category] 바이오마커, [키워드] adipose body fluid Bone marrow Cell Characteristics effector Evidence EVs extracellular vesicle fibrosis heterogeneity highlight immune regulation Intercellular communication mesenchymal stem cell molecular mechanism MSC MSCs overcome paracrine supernatants Support therapeutic therapeutic effect therapy tissue tissue repair Treatment umbilical various tissue Vesicle [DOI] 10.1038/s41419-022-05034-x [Article Type] Reviews
Role of Fc Core Fucosylation in the Effector Function of IgG1 AntibodiesIgG1 항체의 이펙터 기능에서 Fc 코어 푸코실화의 역할Review Published on 2022-06-302022-09-12 Journal: Frontiers in Immunology [Category] MERS, 진단, [키워드] ADCC ADCP antibody Antigen approved B-cell Cancer Cell cellular cytotoxicity Clinical use core decrease Dengue disease severity Effect effector Efficacy ENhance fetal fucosylation function highlighting human IgG1 Fc humoral Humoral response IgG IgG Fc IgG1 IgG1 antibody immune in vitro in vivo Infection Inflammatory diseases knowledge less mAb mAbs Macrophage mechanism Modification monoclonal antibody N-glycan natural immune response natural killer NK cells parasites phagocytosis Platelet polyclonal polymorphonuclear neutrophil pregnant women Regulation reported role SARS-CoV 2 Seven shown significantly therapeutic therapeutic antibodies treat virus virus infection [DOI] 10.3389/fimmu.2022.929895 PMC 바로가기 [Article Type] Review
Immunosuppressant Treatment in Rheumatic Musculoskeletal Diseases Does Not Inhibit Elicitation of Humoral Response to SARS-CoV-2 Infection and Preserves Effector Immune Cell Populations류마티스성 근골격계 질환의 면역억제제 치료는 SARS-CoV-2 감염에 대한 체액 반응의 유발을 억제하지 않고 이펙터 면역 세포 집단을 보존합니다Article Published on 2022-06-102022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료법, [키워드] adaptive addition affected Analysis antibody Antibody Response Antibody responses Arthritis B lymphocytes biologic carried Cellular immune response COVID-19 CTLA4 disease disease-modifying anti-rheumatic drug Disease-modifying anti-rheumatic drugs Diseases DMARD drug effector elicit functional humoral Humoral and cellular immune responses immune immune cell populations immune response immune responses immune system immunological Immunosuppressant include individual Inflammatory Inflammatory arthritis inhibitor inhibitors life-threatening Musculoskeletal Neutralizing activity Pathologies Patient patients treated Population presenting provide RBD protein RBD proteins Re-infections response rheumatic musculoskeletal diseases. SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleocapsid sustained the antibody response TNF-α Treatment virus [DOI] 10.3389/fimmu.2022.873195 PMC 바로가기 [Article Type] Article