Efficacy and safety – Communicable Diseases Research

Preclinical efficacy and safety of novel SNAT against SARS-CoV-2 using a hamster model

Article

Published on 2022-12-012022-11-15
Journal: Drug delivery and translational research
[Category] COVID19(2023년), SARS, 치료제,

Immunogenicity and safety of BNT162b2 mRNA vaccine in Chinese adults: A phase 2 randomised clinical trial

Article

Published on 2022-12-012022-10-06
Journal: The Lancet Regional Health - Western Pacific
[Category] 진단,

[키워드] acute respiratory syndrome Administered Adults adverse event AEs age analysis assessment assigned BNT162b2 BNT162b2 mRNA BNT162b2 mRNA vaccine China Chinese clinical trial Complete Completed conducted coronavirus COVID-19 development dose double-blind Efficacy and safety enrolled Follow-up geometric mean titer GMT GMTs Han Chinese healthy immune response immunogenicity immunogenicity endpoint Inc independent individual injection intramuscular Intramuscular injection investigators Laboratory parameters management messenger Messenger RNA Mild moderate mRNA vaccine Neutralising Antibodies neutralising antibody of BNT162b2 participant Participants pharmaceutical Placebo placebo-controlled trial randomisation randomised Randomly reactogenicity receive recipients recruited reduced remained reported resolved Result robust Safety SARS-CoV-2 SARS-CoV-2 variant SCR second dose sera serious AE seroconversion rate severity Shanghai Sponsor statisticians stratified T-cell Response the placebo group Tolerability Treatment Trial utilised vaccination vaccination. vaccine administration were blinded
[DOI] 10.1016/j.lanwpc.2022.100586 PMC 바로가기 [Article Type] Article

Efficacy and safety of nitazoxanide in treating SARS-CoV-2 infection: a systematic review and meta-analysis of blinded, placebo-controlled, randomized clinical trials

Article

Published on 2022-11-012022-11-15
Journal: European Journal of Clinical Pharmacology
[Category] SARS, 치료제,

[키워드] 95% CI 95% confidence interval addition anti-inflammatory effect antiparasitic antiviral activity blinded clinical benefit continuous variable COVID-19 D-dimer D-dimer level death dichotomous variable Disease progression Effect effect size Efficacy and safety element eligibility enrolled Evidence Frequency ICU admission in vitro individual Inflammation Invasive mechanical ventilation lactate dehydrogenase LDH magnitude Meta-analysis Mild moderate Moderate COVID-19 nitazoxanide no difference Patient patients peer-reviewed performed Placebo placebo-controlled positive positive RT-PCR Primary outcome randomized clinical trial RCT RCTs receiving reducing reduction in reported risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infection. secondary outcome serum biomarker SMD standardized mean difference systematic review tested to define treat treated Viral load WBC were used White blood cell with COVID-19
[DOI] 10.1007/s00228-022-03380-5 PMC 바로가기

Traditional Chinese medicine combined with Moxibustion in the treatment of “long-COVID”: A protocol for systematic review and meta-analysis

Article

Published on 2022-10-282022-11-16
Journal: Medicine
[Category] meta-analysis,

Acupuncture for dry eye disease after recovery from COVID-19: A protocol for systematic review and meta-analysis

Article

Published on 2022-10-282022-11-16
Journal: Medicine
[Category] meta-analysis,

B.1.351 SARS-CoV-2 Variant Exhibits Higher Virulence but Less Viral Shedding than That of the Ancestral Strain in Young Nonhuman Primates

Article

Published on 2022-10-262022-11-16
Journal: Microbiology Spectrum
[Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘,

[키워드] addition Alpha animal model association B.1.351 Beta caused changes in Characteristics Chinese circulating Clinical signs contribute determine distribution drugs early stage Efficacy and safety elevated exhibited IFN-γ IL-17 Infection Inflammatory Inflammatory cytokine interferon gamma interleukin 17 investigated less Lower respiratory tract lung tissue mechanisms mutated Necrosis NHP NHPs nonhuman primate pathogenesis of SARS-CoV-2 pathogenic pathogenicity pathological changes primate provide pulmonary inflammation reduced replicated Research rhesus macaque SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 vaccine SARS-CoV-2 variant SARS-CoV-2 variants severe lung injury shedding spike-specific T-cell response strain Strains tissue TNF-α Transmission upper respiratory tract Vaccine variant variants of concern viral distribution viral shedding virulence virulence. virulent VoC VOCs were infected
[DOI] 10.1128/spectrum.02263-22 PMC 바로가기

A Randomized Phase 2/3 Study of Ensitrelvir, a Novel Oral SARS-CoV-2 3C-Like Protease Inhibitor, in Japanese Patients with Mild-to-Moderate COVID-19 or Asymptomatic SARS-CoV-2 Infection: Results of the Phase 2a Part

Article

Published on 2022-10-182022-11-15
Journal: Antimicrobial Agents and Chemotherapy
[Category] COVID19(2023년), SARS, 치료제,

[키워드] acute respiratory syndrome All adverse event Asymptomatic baseline clinical coronavirus coronavirus disease COVID-19 Culture demonstrated double-blind Efficacy and safety ensitrelvir fumaric acid greater group groups intention-to-treat population Japan Japanese log median time Mild Mild-to-moderate moderate multicenter novel oral Part Patient phase phase 2/3 Placebo positive Primary outcome proof-of-concept study protease Protease inhibitor Randomized receive reduced registry Result S-217622 SARS-CoV-2 SARS-CoV-2 3C-like protease inhibitor SARS-CoV-2 clearance SARS-COV-2 infection SARS-CoV-2 RNA SARS-CoV-2 viral the SARS-CoV-2 tissue Treatment viral clearance Viral RNA viral titer viral titer.
[DOI] 10.1128/aac.00697-22 PMC 바로가기

Comparative efficacy and safety of pharmacological interventions for severe COVID-19 patients: An updated network meta-analysis of 48 randomized controlled trials

Article

Published on 2022-10-142022-11-15
Journal: Medicine
[Category] meta-analysis, 진단,

An overview on nanoparticle-based strategies to fight viral infections with a focus on COVID-19

Article

Published on 2022-10-082022-11-15
Journal: Journal of Nanobiotechnology
[Category] COVID19(2023년), SARS, 치료제,

Systematic Down-Selection of Repurposed Drug Candidates for COVID-19

Article

Published on 2022-10-062022-11-15
Journal: International Journal of Molecular Sciences
[Category] COVID19(2023년), SARS, 변종, 신약개발, 치료제,