Diffusion-Induced Ingress of Angiotensin-Converting Enzyme 2 into the Charge Conducting Path of a Pentacene Channel for Efficient Detection of SARS-CoV-2 in Saliva SamplesArticle Published on 2022-10-282022-11-15 Journal: ACS Sensors [Category] COVID19(2023년), SARS, 치료기술, [키워드] accelerate ACE2 angiotensin-converting enzyme 2 Angiotensin-converting enzyme 2 (ACE2) biosensor can be used channel charge Conducting correlation COVID-19 detection diagnostic test disease efficient false-negative field-effect transistor. gold standard growth handling highest integration Laboratory Large-scale testing less medium molecular Organic field-effect transistor path pathogen platform POC point-of-care Rapid receptor remote monitoring reported Saliva Sample SARS-CoV-2 sensitivity specimens Spread statistical analysis the disease the epidemic the SARS-CoV-2 virus the spike protein transfer Viral RNA viral titer virus [DOI] 10.1021/acssensors.2c01287 PMC 바로가기
The Efficient and Practical virus Identification System with ENhanced Sensitivity for Solids (EPISENS-S): A rapid and cost-effective SARS-CoV-2 RNA detection method for routine wastewater surveillance고형물에 대한 감도가 향상된 효율적이고 실용적인 바이러스 식별 시스템(EPISENS-S): 일상적인 폐수 감시를 위한 빠르고 비용 효율적인 SARS-CoV-2 RNA 검출 방법Article Published on 2022-10-152022-09-11 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] applicability centrifugation city collected Concentration confirmed COVID-19 case COVID-19 demonstrated Detection sensitivity efficient Epidemiology evaluated examined followed by heat heat-inactivated identification Japan magnitude Mild multiplex normalized pellet Pepper mild mottle virus plant primer Primers qPCR qPCR quantification Quantification method quantified ranged reported reverse primer reverse primers RNA concentration RNA concentrations RNA extraction SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 RNA detection sensitivity Solid subsequent Surveillance System target targets the SARS-CoV-2 Treatment virus wastewater Wastewater-based epidemiology [DOI] 10.1016/j.scitotenv.2022.157101 PMC 바로가기 [Article Type] Article
Efficient electrochemical oxidation of COVID-19 treatment drugs favipiravir by a novel flow-through Ti/TiO2-NTA/Ti4O7 anodeResearch article Published on 2022-10-012022-10-05 Journal: Electrochimica Acta [Category] 치료법, 치료제, [키워드] accelerated COVID-19 degradation mechanism drug Effect effective Efficiency efficient Electrochemical oxidation electron transfer Evolution exhibited Favipiravir FIVE flow-through investigated oxygen parameter porous remained significantly stability Ti4O7 TiO2 nanotubes Treatment was reduced were used [DOI] 10.1016/j.electacta.2022.141055 [Article Type] Research article
Efficient antibody evasion but reduced ACE2 binding by the emerging SARS-CoV-2 variant B.1.640.2Article Published on 2022-09-012022-11-16 Journal: Cellular and Molecular Immunology [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 binding antibody efficient reduced SARS-CoV-2 variant [DOI] 10.1038/s41423-022-00870-5 PMC 바로가기
Efficient discovery of SARS-CoV-2-neutralizing antibodies via B cell receptor sequencing and ligand blockingArticle Published on 2022-08-012022-11-15 Journal: Nature biotechnology [Category] SARS, 진단, [키워드] ACE2 acute respiratory syndrome angiotensin-converting enzyme 2 antibody Antigen approach approved B cell binding Candidates Combination coronavirus coronavirus disease COVID-19 described efficient inefficient Ligand mAb mAbs monoclonal antibody Neutralizing Neutralizing antibodies Prevent Protein receptor SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2-neutralizing antibody Sequencing specificity therapy [DOI] 10.1038/s41587-022-01232-2 PMC 바로가기
Spatially Patterned Neutralizing Icosahedral DNA Nanocage for Efficient SARS-CoV-2 Blocking효율적인 SARS-CoV-2 차단을 위한 공간적으로 패턴화된 중화 정이십면체 DNA 나노케이지Article Published on 2022-07-272022-09-11 Journal: Journal of the American Chemical Society [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] aggregation alleviate anti-SARS-CoV-2 assembly binding binding site blocking composed conformational disease-causing DNA efficient ENhance exhibit form global public health Host induce Infection inhibit inhibitory effect limit moderate multidimensional mutant strain Mutant strains neutralization Neutralizing omicron positioned Prevent provide pseudovirus reagent SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike trimer spike trimer steric the SARS-CoV-2 threat triangular Viral viral infection virus viruses wild-type [DOI] 10.1021/jacs.2c02764 PMC 바로가기 [Article Type] Article
Fluorescent Platforms for RNA Chemical Biology ResearchRNA 화학 생물학 연구를 위한 형광 플랫폼Review Published on 2022-07-272022-09-11 Journal: Genes [Category] 치료제, [키워드] activities activity applied assays binding Biology Biotin change Chemical Chemical biology Clinical research clinically COVID-19 test COVID-19 tests CRISPR Degradation demonstrated detect Drug discovery drugs targeting Efficacy Efficiency efficient energy transfer ENhance enzyme Enzyme labeling example facilitate fit Fluorescence fluorescence anisotropy Fluorescence imaging fluorescent fluorescent assays. Forced In situ hybridization increase invention lAbel labeling living cells Mango microRNA miRNA movement mRNA ncRNAs non-coding RNA Non-coding RNAs Nuclease observation overcome probe Research ribonucleoprotein RNA ROI subcellular T-box tumors [DOI] 10.3390/genes13081348 PMC 바로가기 [Article Type] Review
Studies in the antiviral molecular mechanisms of 25-hydroxycholesterol: Disturbing cholesterol homeostasis and post-translational modification of proteins25-하이드록시콜레스테롤의 항바이러스 분자 메커니즘 연구: 콜레스테롤 항상성 교란 및 단백질의 번역 후 변형Review Published on 2022-07-052022-09-11 Journal: European journal of pharmacology [Category] 치료제, [키워드] 25-Hydroxycholesterol activating Antiviral antiviral activity antiviral drug antiviral drugs Antiviral mechanism binding catalyzed cholesterol cholesterol homeostasis contribute coronavirus disease Coronavirus disease 2019 Efficiency efficient endoglycosidase endosomal pathway global public health glycan glycans glycosylation hydroxylase impair in vitro in vivo inhibiting Innate immunity Lipid Lipid raft liver Maturity mechanisms Modification molecular mechanism nucleic acid outbreak oxysterol oxysterol-binding protein pathway post-translational modification prenylation Previous studies previous study Protein reactive receptor reduce restrict second sensitivity shown Sterol Toxicity Viral protein Viral proteins virus [DOI] 10.1016/j.ejphar.2022.175033 PMC 바로가기 [Article Type] Review
Virus-Like Particles Are Efficient Tools for Boosting mRNA-Induced Antibodies바이러스 유사 입자는 mRNA 유도 항체를 강화하기 위한 효율적인 도구입니다Article Published on 2022-06-162022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] antibodies Antibody Response Antibody responses approved boost COVID-19 economics Efficacy efficient Heterologous heterologous prime-boost heterologous prime-boost vaccination strategies homologous investigated maintain mRNA mRNA-1273 mRNA-1273 vaccine overcome Particle priming reduced regimen SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 variant the antibody response Vaccination strategy Vaccine vaccine candidate Virus-like particle virus-like particles VLP VLPs VOCs were used [DOI] 10.3389/fimmu.2022.864718 PMC 바로가기 [Article Type] Article
Efficient recall of Omicron-reactive B cell memory after a third dose of SARS-CoV-2 mRNA vaccineSARS-CoV-2 mRNA 백신 3차 접종 후 오미크론 반응성 B 세포 기억의 효율적인 회수Article Published on 2022-05-262022-09-11 Journal: Cell [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] added Alpha antibody Antibody titer Antibody titers Antigen B cell memory Beta booster Cell circulating antibodies circulating antibody correlated COVID-19 Delta dose efficient examined fold immune immune memory Immunity IMPROVE increase in limit memory B memory B cell memory B cells mRNA mRNA vaccination mRNA vaccine neutralizing antibody titers omicron Omicron variants quantity RBD-specific memory B cells recall remained response SARS-CoV-2 spike These data vaccination Vaccine variants variants of concern wild-type [DOI] 10.1016/j.cell.2022.04.009 PMC 바로가기 [Article Type] Article