EGF – Communicable Diseases Research

Urinary Epidermal Growth Factor Level as a Noninvasive Indicator of Tubular Repair in Patients with Acute Kidney Injury

Article

Published on 2024-04-302024-09-05
Journal: Diagnostics [Category] update2024,

Maternal and neonatal immune response to SARS-CoV-2, IgG transplacental transfer and cytokine profile

Article

Published on 2022-09-272022-11-15
Journal: Frontiers in Immunology [Category] SARS, 진단, 치료기술,

[키워드] 229E antibodies antibody Barcelona Blood blood sample C-terminus cause chemokine collected Concentration concentrations COVID-19 cytokine level cytokine levels cytokine profile cytokine response Cytokines distress domain EGF FGF full-length growth factor higher risk HKU1 human coronavirus Humoral response IFN-α IgA level IgG IgM IL-15 IL-17 IL-7 immune response immunological increased risk induce Infection Inflammatory investigated male Maternal maternal and neonatal immunity mother Neonatal Newborn NL63 non-infected nucleocapsid OC43 outcome outcomes positive positive correlation positive for rRT-PCR Pregnancy pregnant women Preterm birth profiles Questionnaires RANTES recruited reduction robust rRT-PCR SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 detection SARS-COV-2 infection SARS-CoV-2-specific IgG SARS-CoV-2-specific IgGs serology severe COVID-19 Spain Swab Symptom symptomatic tested transfer transplacental transfer. Vaccines variables was increased were infected were recorded women
[DOI] 10.3389/fimmu.2022.999136 PMC 바로가기

SARS-CoV-2 infection- induced growth factors play differential roles in COVID-19 pathogenesis

SARS-CoV-2 감염 유발 성장 인자는 COVID-19 발병 기전에서 다른 역할을 합니다

Article

Published on 2022-09-012022-09-11
Journal: Life sciences [Category] COVID19(2023년), MERS, SARS, 바이오마커, 치료기술,

[키워드] adverse effect adverse effects angiopoietin association COVID-19 COVID-19 pathogenesis COVID-19 patient Critical Critically ill cytokine Cytokine storm Cytokine storms Cytokines D-dimer disease dysregulation EGF elevated Endothelial dysfunction EPO erythropoietin exhibited G-CSF growth factor Growth factors HGF Hospitalized ICU Inflammation Injury inverse correlation investigation marker moderate Myoglobin negative correlation non-ICU occur P-selectin Pathogenesis pathogenesis of COVID-19 pathophysiology PDGF plasma positive correlation reflected remained repair SARS-COV-2 infection selectin specific disease Thromboembolism tissue tissue injury Tissue injury. upregulated vague VEGF was performed
[DOI] 10.1016/j.lfs.2022.120703 PMC 바로가기 [Article Type] Article

Prognostic Significance of Urinary Biomarkers in Patients Hospitalized With COVID-19

COVID-19로 입원한 환자의 요도 바이오마커의 예후적 의미

Article

Published on 2022-02-012022-09-11
Journal: American journal of kidney diseases : the official [Category] COVID19(2023년), SARS, 바이오마커,

[키워드] Acute kidney injury Acute kidney injury (AKI) acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 AKI association Biomarker Chronic kidney disease chronic kidney disease (CKD) cohort study Combination comparable Composite coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) COVID-19 COVID-19 patient COVID-19 prognosis Cox proportional hazard creatinine death defined dialysis discrimination EGF elevated epidermal epidermal growth factor epidermal growth factor (EGF) events Evidence evidence of growth factor highest Hospital admission Hospitalized Improving individual Inflammation Inflammatory Inflammatory marker information Injury investigated KDIGO kidney Kidney disease Kidney injury kidney injury molecule 1 (KIM-1) lower risk MCP-1 Microscopy moderate MONITOR monocyte monocyte chemoattractant protein 1 monocyte chemoattractant protein 1 (MCP-1) neutrophil neutrophil gelatinase-associated lipocalin (NGAL) outcome outcomes Patient patients patients hospitalized patients with COVID-19 Primary outcome prognostic progression Prospective prospective cohort study Protein provided rationale repair respiratory risk Sample size serum creatinine setting severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Significance small sample size subclinical AKI tubular injury Urinalysis urinary urinary biomarkers Urine urine microscopy. with COVID-19
[DOI] 10.1053/j.ajkd.2021.09.008 PMC 바로가기 [Article Type] Article

Comparative Metabolomics and Proteomics Reveal Vibrio parahaemolyticus Targets Hypoxia-Related Signaling Pathways of Takifugu obscurus

Immunology

Published on 2022-01-132022-11-01
Journal: Frontiers in Immunology [Category] COVID-19,

Sample Processing and Stability for Urine Biomarker Studies

소변 바이오마커 연구를 위한 시료 처리 및 안정성

Article

Published on 2021-11-012022-09-11
Journal: The journal of applied laboratory medicine [Category] MERS, SARS, 바이오마커,

[키워드] 48 hour 48 hours acute kidney Acute kidney injury Alpha Biomarker Biomarkers biospecimen handling biospecimen storage centrifugation chitinase collected Concentration condition conditions COVID-19 COVID-19 pandemic current demonstrated determine Device Effect EGF epidermal epidermal growth factor Foley catheter freezing growth factor handling hospitalized patient IL-12p70 IL-13 IL-18 IL-1β IL-2 IL-4 IL-6 IL-8 interferon gamma interleukin investigated Kidney injury MCP-1 measurement monocyte monocyte chemoattractant protein-1 Necrosis neutrophil New notable osteopontin processing Protein protein stability reference standard remained Research robust Sample significant difference significant differences spot tested TNF-α Tumor tumor necrosis tumor necrosis factor tumor necrosis factor alpha UMOD Urinalysis urinalysis. Urine Variation variations were used YKL-40
[DOI] 10.1093/jalm/jfab082 PMC 바로가기 [Article Type] Article

Presentation of cytokine profile in relation to oxidative stress parameters in patients with severe COVID-19: a case-control pilot study

Research Article

Published on 2021-10-142022-10-31
Journal: F1000Research [Category] COVID-19, MERS, SARS,

Longitudinal urinary biomarkers of immunological activation in covid-19 patients without clinically apparent kidney disease versus acute and chronic failure

임상 적으로 명백한 신장 질환이없는 COVID-19 환자에서 급성 및 만성 부전이없는 환자에서 면역 학적 활성화의 종 방향 비뇨기 바이오 마커

Article

Published on 2021-10-042022-08-31
Journal: Scientific Reports [Category] MERS, SARS, 바이오마커, 유전자 메커니즘,

[키워드] Activation Acute kidney injury Admission affected APACHE Biomarker Blood CCL23 Chronic kidney disease clinical status clinically collected condition correlated COVID-19 Critical cross-sectional cross-sectional study CXCL6 DCN death demise dysfunction EGF ferritin followed by Gender Hospital admission IFNg IgM and IgG IL-12 IL-15 IL-18 IL-2 IL-5 IL-6 immune activation immune response immune system immunological immunology inflammatory markers kidney Kidney disease Kidney function Kidney injury LAG-3 longitudinal marker MCP-1 MCP-3 MMP7 modulate modulating Nephrology Non-survivors Patient patients PD-L1 PGF predicted Probability procalcitonin PTN Serum level Seven Spike protein Steroids trajectory unique urinary Urine Viral viral burden
[DOI] 10.1038/s41598-021-99102-5 PMC 바로가기 [Article Type] Article

Diverse Humoral Immune Responses in Younger and Older Adult COVID-19 Patients

Research Article

Published on 2021-06-292022-10-29
Journal: mBio [Category] COVID-19, MERS, SARS,

[키워드] acute respiratory syndrome age Amino acid antibody antibody reactivity Antibody Response antigenic B.1.1.7 B.1.526 B1.351 CD40 ligand chemokine clinical outcomes Clinical severity clinical variables Cohort collected coronavirus Coronaviruses correlation COVID-19 cytokine Cytokine analysis EGF elevated Endemic Endemic coronaviruses epidermal epitope Epitopes Frame group growth factor HCoV-NL63 HCoV-OC43 human coronavirus OC43 Humoral immunity IgG antibody IL-10 IL-15 in vitro transcription individual interferon IP-10 mechanically ventilated membrane MERS-CoV Microarray Middle East Mutation nucleocapsid Older Older age older patient ORF overlap overlapping P.1 Patient patients probe profiles Protein Proteins Region respiratory syndrome coronavirus response SARS-CoV SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 spike SARS-CoV-2 variant selected serum sample significantly significantly higher subset systemic cytokine the N protein the S1 protein translation Ventilated Viral variants
[DOI] 10.1128/mBio.01229-21 PMC 바로가기 [Article Type] Research Article

Viral fibrotic scoring and drug screen based on MAPK activity uncovers EGFR as a key regulator of COVID-19 fibrosis

MAPK 활성을 기반으로 한 바이러스성 섬유증 스코어링 및 약물 스크리닝은 COVID-19 섬유증의 주요 조절자로서 EGFR을 밝혀냅니다

Article

Published on 2021-05-272022-09-10
Journal: Scientific Reports [Category] 신약개발, 치료제,

[키워드] ACE2 activity Analysis Antiviral antiviral activity approach Cell cell line Cell signalling Cluster cluster of gene complication of COVID-19 correlation COVID-19 COVID-19 progression COVID-19 research COVID-19 treatment Data mining Data processing downregulate drug Drug discovery dual EGF EGFR entry receptor epidermal epidermal growth factor ErbB ERK fibrosis growth factor Host Idiopathic pulmonary fibrosis imaging in vitro infected cells inhibitor inhibitors involved lung cells machine learning MAPK molecular basis Patient phenotype predicted provide pulmonary fibrosis quantified responsible RNA-sequencing SARS-CoV-2 SARS-CoV-2-infected cell SARS-CoV-2-infected cells sequencing data Signaling the cells transcriptomic transcriptomic data Treatment understanding utility Virtual drug screening
[DOI] 10.1038/s41598-021-90701-w PMC 바로가기 [Article Type] Article