New insights into antibody levels against SARS-CoV-2 for healthcare personnel vaccinated with tozinameran (Comirnaty)Article Published on 2022-11-032022-11-15 Journal: PLoS ONE [Category] SARS, 진단, [키워드] activated addition addressed administration Alto Andújar antibody booster dose COVID-19 determine Dilution Elecsy Evolution exhibited Germany Guadalquivir healthcare personnel Healthcare professional humoral IgG in vitro infected patients material Neutralizing antibodies New non-infected pandemic platform Roche SARS-CoV-2 SARS-CoV-2 vaccine second dose serum sample Spike protein subject Thermo Fisher Scientific titer total antibody vaccination Vaccine Volunteer volunteers [DOI] 10.1371/journal.pone.0276968 PMC 바로가기
Comparison of SARS-CoV-2 spike antibody quantitative titer reporting using the World Health Organization International Standard Units by four commercial assaysArticle Published on 2022-11-012022-11-15 Journal: Journal of Clinical Virology [Category] SARS, 진단, [키워드] Abbott Accuracy antibodies antibody Antibody Response Antibody titer Architect BAU BNT162b2 ChAdOx1-S collected comparable correlation COVID-19 DiaSorin effective Elecsy elicited Genscript greater IgG immune response Immunoglobulin indicated individual International LIAISON Moderna mRNA-1273 naïve Neutralizing antibody titer Oxford-AstraZeneca Pfizer/BioNTech plasma protective immunity Quantitative Quantitative serological assays ranged regression analysis response Roche SARS-CoV-2 SARS-CoV-2 IgG SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 vaccination sensitivity seroconverted serological serological response significantly higher specificity Standard tested the WHO unit Vaccine Vaccines virus neutralization assays WHO WHO International Standard World Health Organization [DOI] 10.1016/j.jcv.2022.105292 PMC 바로가기
Concordance of SARS-CoV-2 Antibody Results during a Period of Low PrevalenceArticle Published on 2022-10-262022-11-15 Journal: mSphere [Category] COVID19(2023년), SARS, 진단, [키워드] 95% confidence interval Abbott acute respiratory syndrome Analysis anti-SARS-CoV-2 anti-SARS-CoV-2 antibody anti-SARS-CoV-2 IgG Antigen antigens Architect assays CDC collected combinations Concentration Concordance contributed coronavirus coronavirus disease COVID-19 Elecsy ELISA enzyme-linked immunosorbent evaluate False positivity first test Frequency IgG IgG antibodies immunoassay immunoassays Immunoglobulin individual investigated low prevalence nucleocapsid nucleocapsid protein pandemic participant Participants performed Period positive positive result Prevalence produced proportion quantified Research Result Roche SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 IgG SARS-CoV-2 IgG antibody sequential test sera serological test seropositive specimen Spike protein subset Support target tested the SARS-CoV-2 The United States Vaccine vaccine availability [DOI] 10.1128/msphere.00257-22 PMC 바로가기
Evaluation of ECLIA antigen detection tests as screening methods for COVID-19 in comparison with molecular analysisArticle Published on 2022-10-012022-11-15 Journal: Irish Journal of Medical Science [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] Antigen antigen detection antigen test approach assumed COVID-19 cycle threshold diagnosis of COVID-19 Diagnostic methodology Elecsy electrochemiluminescence immunoassay evaluate Germany gold standard molecular analysis Patient positive processed Roche Diagnostics rRT-PCR RT-qPCR SARS CoV SARS-CoV-2 SARS-CoV-2 viral screening method selected sensitivity Sensitivity and specificity Support Swab viral loads [DOI] 10.1007/s11845-021-02863-1 PMC 바로가기
Reactogenicity and immunogenicity of the second COVID-19 vaccination in patients with inborn errors of immunity or mannan-binding lectin deficiencyArticle Published on 2022-09-142022-11-15 Journal: Frontiers in Immunology [Category] SARS, 진단, 치료기술, [키워드] activity Adverse reaction analyzed Anti-SARS-CoV-2 S antibody Antibody Response Autoimmune Autoimmune diseases B-lymphocytes Cell Cohort cohort of patient comparable Course COVID-19 COVID-19 vaccination CVID deficiency detect Disease activity dysfunction effective Efficacy and safety Elecsy flow cytometry healthy control humoral humoral immune response Hypogammaglobulinemia IFN-gamma immune system Immunity immunization immunoassay immunodeficiency immunoglobulin replacement therapy in healthy individuals increased risk individual Interferon-gamma lymphocyte neutralization Patient Phenotyping pneumococcal provide reactogenicity receptor Safe SARS-COV-2 infection selective Seven subjects Support syndrome T cell response T-lymphocites the disease triggering underlying disease vaccination vaccine response Vero E6 Virus neutralization was performed well X-linked agammaglobulinemia XLA [DOI] 10.3389/fimmu.2022.974987 PMC 바로가기
Kinetics of anti-SARS-CoV-2 antibody titer in healthy adults up to 6 months after BNT162b2 vaccination measured by two immunoassays: A prospective cohort study in JapanArticle Published on 2022-09-092022-11-15 Journal: Vaccine [Category] SARS, 진단, [키워드] Abbott acute respiratory syndrome Adults age anti-RBD Anti-RBD antibody anti-RBD antibody response anti-receptor-binding domain anti-SARS-CoV-2 antibody Anti-SARS-CoV-2 S antibody Antibody Response Antibody titer Architect Architect SARS-CoV-2 IgG II Quant assays blood sample BNT162b2 BNT162b2 mRNA vaccine BNT162b2 vaccine collected comparable Coronavirus-2 correlation dose Elecsy Elecsys Elecsys Anti-SARS-CoV-2 S evaluated first vaccination geometric GMT GMT ratio GMTs healthcare healthy immunoassay immunoassays Japan Kinetics mRNA vaccine no significant difference Older age Participants prospective cohort study RBD Roche Diagnostics SARS-CoV-2 SARS-CoV-2 IgG second vaccination Sex significantly lower Spearman vaccination were measured [DOI] 10.1016/j.vaccine.2022.08.018 PMC 바로가기
Antinucleocapsid Antibodies After SARS-CoV-2 Infection in the Blinded Phase of the Randomized, Placebo-Controlled mRNA-1273 COVID-19 Vaccine Efficacy Clinical TrialArticle Published on 2022-09-012022-11-15 Journal: Annals of internal medicine [Category] COVID19(2023년), SARS, 진단, [키워드] Analysis antibody blinded clinical COVID-19 Delta diagnosed Diagnosis double-blind Efficacy Elecsy evaluate evaluated had no higher odd immunoassay increase in Infection Infectious disease injection median Moderna mRNA-1273 occurred Odds ratio Older omicron participant PCR PCR-confirmed COVID-19 phase Phase 3 Placebo placebo recipient placebo-controlled polymerase chain Randomized risk Sample size SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 viral Seroconversion serum sample severe COVID-19 Swab tested The United States Treatment Trial vaccination Vaccination Status Vaccine vaccinee [DOI] 10.7326/M22-1300 PMC 바로가기
Performance analysis among multiple fully automated anti-SARS-CoV-2 antibody measurement reagents: A potential indicator for the correlation of protection in the antibody titer여러 완전 자동화된 anti-SARS-CoV-2 항체 측정 시약 간의 성능 분석: 항체 역가의 보호 상관 관계에 대한 잠재적 지표Article Published on 2022-09-012022-09-11 Journal: Journal of infection and chemotherapy : official j [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] access acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis analyzed anti-SARS-CoV-2 antibody antibody Antibody detection antibody tests Antibody titer Architect automated Clinical use coronavirus correlated correlation COVID-19 detection diagnosed Elecsy Elecsys evaluate expected FIVE IgG IgM Infection late stage linearity neutralizing antibody Patient performance positive Precision Quantitative reagent reference values respiratory SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 IgM SARS-COV-2 infection serum sample serum samples severe acute respiratory syndrome Coronavirus sVNT virus-neutralizing was used [DOI] 10.1016/j.jiac.2022.05.016 PMC 바로가기 [Article Type] Article
Humoral and Cellular Immune Responses to Vector, Mix-and-Match, or mRNA Vaccines against SARS-CoV-2 and the Relationship between the Two Immune ResponsesArticle Published on 2022-08-312022-11-15 Journal: Microbiology Spectrum [Category] SARS, 진단, 치료기술, [키워드] Abbott acute respiratory syndrome Affect affected affecting age age and sex analyzed anti-SARS-CoV-2 antibody Antibody detection BAU binding antibody unit BNT162b2 cellular Cellular immune response cellular immune responses ChAdOx1 nCoV-19 coronavirus correlation Cutoff demonstrated determine Effect Elecsy evaluated Factor female first vaccination Genscript group humoral humoral immune responses immune immune response immune responses interferon gamma investigated male mix-and-match vaccine mRNA mRNA vaccine mRNA-1273 neutralizing antibody predict Qiagen QuantiFERON RBD regimen regimens relationship response robust Roche SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 neutralization second vaccination Sex subject T cell response T cell responses the receptor-binding domain vaccination Vaccine vaccine group vector vector vaccine venous blood was collected were used [DOI] 10.1128/spectrum.02495-21 PMC 바로가기
Detecting Waning Serological Response with Commercial Immunoassays: 18-Month Longitudinal Follow-up of Anti-SARS-CoV-2 Nucleocapsid AntibodiesArticle Published on 2022-08-312022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 진단, 치료기술, 치료제, [키워드] Abbott Accuracy acute respiratory syndrome adjusted Analysis anti-SARS-CoV-2 anti-SARS-CoV-2 immune response antibodies antibody Antibody concentrations Antibody detection Architect cohorts commercial immunoassay conducted convalescent individual coronavirus coronavirus disease COVID-19 cumulative dependent on Detection limit Elecsy ELISA enzyme-linked immunosorbent evaluated Follow-up Health care worker heterogenous highest IgG immune responses immunoassay immunoassays incidence individual Infection longitudinal lowest nucleocapsid protein Patient Reinfection response Roche SARS-CoV-2 SARS-CoV-2 IgG SARS-COV-2 infection SARS-CoV-2 infections selected serological serological kinetics serum serum antibody Surveillance tested the SARS-CoV-2 threshold unique waning antibody. [DOI] 10.1128/spectrum.00986-22 PMC 바로가기