Multisystem Inflammatory Syndrome in Children During Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Delta and Omicron Variant Circulation-United States, July 2021-January 2022Article Published on 2022-10-032022-11-16 Journal: Clinical Infectious Diseases: An Official Publicat [Category] COVID19(2023년), SARS, 변종, [키워드] Care center Child children circulation Control coronavirus 2 COVID-19 Delta died eligible patient Epidemiology Inflammatory intensive care MIS-C multisystem inflammatory syndrome in children omicron Patient prevention reported respiratory SARS-CoV-2 syndrome [DOI] 10.1093/cid/ciac471 PMC 바로가기
Efficacy and safety of SARS-CoV-2 vaccination in patients with inflammatory bowel disease on immunosuppressive and biological therapy: Prospective observational studyObservational Study Published on 2022-09-022022-10-05 Journal: PLoS ONE [Category] SARS, 임상, 진단, [키워드] adverse event Anaphylactic reaction antibody BNT162b2 combination therapy COVID-19 COVID-19 pandemic dose Efficacy and safety eligible patient evaluate evaluated event geometric group Health immunosuppressive indicated Inflammatory bowel disease Local majority MONITOR Patient patients Prospective prospective observational study SARS-CoV-2 SARS-CoV-2 IgG antibody SARS-CoV-2 vaccination significant difference therapy treated U/mL vaccination vaccination against COVID-19 Vaccine vaccine administration [DOI] 10.1371/journal.pone.0273612 PMC 바로가기 [Article Type] Observational Study
Comparison between the persistence of post COVID-19 symptoms on critical patients requiring invasive mechanical ventilation and non-critical patientsObservational Study Published on 2022-08-222022-10-04 Journal: PLoS ONE [Category] SARS, 임상, [키워드] addition adjusted affected association Asymptomatic Care Cognitive impairment collected complications coronavirus disease COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 symptom Critical develop discharged Dyspnea eligible patient evaluate fatigue Follow-up headache Health Assessment hospital Hospital stay Hospitalization ICU IMV intubation Invasive mechanical ventilation median age men multisystemic Multivariate analysis Musculoskeletal musculoskeletal symptom Neuropsychiatric participant Patient patients performed persistence physician predominant proportion Psychological questionnaire reported required Respiratory disease severe COVID-19 disease significant difference Symptom Symptoms syndrome [DOI] 10.1371/journal.pone.0273041 PMC 바로가기 [Article Type] Observational Study
Association between tocilizumab, sarilumab and all-cause mortality at 28 days in hospitalised patients with COVID-19: A network meta-analysis코로나19로 입원한 환자에서 토실리주맙, 사릴루맙, 28일 후 모든 원인 사망률 사이의 연관성: 네트워크 메타 분석Meta-Analysis Published on 2022-07-082022-09-11 Journal: PLoS ONE [Category] meta-analysis, 임상, 진단, [키워드] 28-day mortality all-cause mortality antagonist association choice clinician Consistency Corticosteroid Corticosteroids COVID-19 patient deaths demonstrated dependent on Effect eligible patient Evidence hospitalised patient Hospitalised patients in-hospital mortality inconsistency initiated interleukin-6 interleukin-6 receptor invasive ventilation Meta-analysis Network meta-analysis Non-invasive not dependent Odds ratio Odds ratios P-value Patient Placebo randomisation randomised randomised comparison receiving receptor antagonist REMAP-CAP REMAP-CAP trial sarilumab Tocilizumab Trial usual care Ventilation with COVID-19 [DOI] 10.1371/journal.pone.0270668 PMC 바로가기 [Article Type] Meta-Analysis
Effect of treatment interruptions and outcomes in cancer patients undergoing radiotherapy during the first wave of COVID-19 pandemic in a tertiary care instituteObservational Study Published on 2022-07-042022-10-05 Journal: Journal of the Egyptian National Cancer Institute [Category] 임상, [키워드] Analysis Cancer cancer patient Care clinically cohorts of patients Comorbidities conducted COVID-19 COVID-19 pandemic COVID-19 patient disease Disease progression Effect effect of treatment eligible patient First wave Follow-up fraction Fractions general condition Immunosuppression impacted India less material Observational cohort study outcome outcomes Patient patients patients died patients treated positive Primary outcome Radiation radiation therapy Radiotherapy recovering from COVID-19 reported retrospective significant difference the patient Treatment Treatment interruption Treatment outcome treatment outcomes two groups [DOI] 10.1186/s43046-022-00129-0 PMC 바로가기 [Article Type] Observational Study
Effect of a home-based inspiratory muscular training programme on functional capacity in patients with chronic COVID-19 after a hospital discharge: protocol for a randomised control trial (InsCOVID trial)퇴원 후 만성 COVID-19 환자의 기능 능력에 대한 가정 기반 흡기 근육 훈련 프로그램의 효과: 무작위 대조 시험 프로토콜(InsCOVID 시험)Article Published on 2022-07-012022-09-11 Journal: BMJ Open Respiratory Research [Category] 임상, [키워드] 1:1 acute respiratory syndrome acute respiratory syndrome coronavirus Admission analysis of variance approved baseline blinded coronavirus COVID-19 COVID-19 patients Declaration of Helsinki discharged Effect eight eligible patient enrolled Ethics evaluate exercise exercise intolerance fatigue finding functional functional capacity groups Helsinki hospital Hospital admission hospital discharge IMPROVE inspiratory muscle Intervention muscles muscular National outcome Patient peer-reviewed Pneumonia primary endpoint protocol pulmonary rehabilitation randomised randomised controlled trial receive registration number Regulation Research Research Ethics Research Ethics Committee respiratory muscles Supervised exercise Symptom symptomatic Symptoms the primary endpoint Trial usual care usual care alone variance [DOI] 10.1136/bmjresp-2022-001255 PMC 바로가기 [Article Type] Article
Remdesivir and three other drugs for hospitalised patients with COVID-19: final results of the WHO Solidarity randomised trial and updated meta-analyses코로나19 입원 환자를 위한 렘데시비르 및 기타 3가지 약물: WHO 연대 무작위 시험의 최종 결과 및 업데이트된 메타 분석Meta-Analysis Published on 2022-05-212022-09-11 Journal: Lancet (London, England) [Category] 신약개발, 임상, 치료제, [키워드] 1:1 allocation Analysis antiviral drugs assigned average both groups Characteristics Compliance controls country COVID-19 COVID-19 diagnosis database death died discharge discharged disease severity drug drugs eligible patient Endpoint enrolled exclusion Final futility hospital Hospital mortality hospitalised hospitalised patient Hospitalised patients Hydroxychloroquine in both groups in-hospital mortality Inpatient Inpatients interferon ISRCTN Kaplan-Meier Local Lopinavir meta-analyses Meta-analysis Mortality mortality analysis mortality rate ratio no significant effect occurred Open-label outcome oxygen participant Patient patients patients with COVID-19 Placebo placebos primary endpoint progressed progression proportion randomisation Randomised trial Randomly rate ratio receive recruited regions Registered Remdesivir reported secondary Secondary endpoints solidarity Solidarity trial Standard of care study drug the WHO treatment period Trial Ventilated Ventilation were given WHO [DOI] 10.1016/S0140-6736(22)00519-0 PMC 바로가기 [Article Type] Meta-Analysis
Study protocol to test the efficacy of self-administration of dexmedetomidine sedative therapy on anxiety, delirium, and ventilator days in critically ill mechanically ventilated patients: an open-label randomized clinical trial중환자 기계 환기 환자의 불안, 섬망 및 인공 호흡기 일에 대한 덱스메데토미딘 진정 요법의 자가 투여 효과를 테스트하기 위한 연구 프로토콜: 공개 라벨 무작위 임상 시험Article Published on 2022-05-162022-09-11 Journal: Trials [Category] 임상, [키워드] addition aggregate alertness alleviate alteration Anxiety approach approaches assigned Care change clinical Clinical practice clinical trial Consistency Course COVID-19 case COVID-19 pandemic Critically ill delirium Depression dexmedetomidine distress Efficacy eligible Eligible participants eligible patient Eligible patients enrolment equipment extubation finding flexible functional Functional status healthcare ICU ICU care ICU patient ICU Patients identify impacted imperative intensive care intensive care unit life management Mechanical mechanical ventilation mechanical ventilatory support mechanically ventilated mechanically ventilated patient mechanically ventilated patients medication Open-label opioid outcome Oxygenation Pain Patient patient symptom Patient symptoms physical Post-traumatic stress disorder Protective protocol Psychological well-being Quality of life randomization Randomized randomized clinical trial Randomly receiving recruitment Secondary objective Secondary objectives Sedation sedative Self-management Side effects significantly study population subset Symptom therapy Trial trial enrolment usual care ventilator ventilator-free day Ventilator-free days ventilatory support [DOI] 10.1186/s13063-022-06391-w PMC 바로가기 [Article Type] Article
Opportunities and counterintuitive challenges for decentralized clinical trials to broaden participant inclusion Reviews Published on 2022-05-052022-10-05 Journal: NPJ Digital Medicine [Category] 바이오마커, 유전자 메커니즘, 임상, [키워드] approach build clinical trial complex consequence DCT elements eligible patient Evidence exclusion Gender groups Implementing improvement Inclusion infection control medication opportunity participant Patient populations provide recruit recruitment reduce reducing required Research researcher Traditional Travel Trial US FDA while [DOI] 10.1038/s41746-022-00603-y [Article Type] Reviews
Venovenous extracorporeal membrane oxygenation in patients with acute covid-19 associated respiratory failure: comparative effectiveness studyObservational Study Published on 2022-05-042022-10-05 Journal: The BMJ [Category] COVID19(2023년), SARS, 임상, [키워드] 95% confidence interval adherence adjusted Admission baseline calculated clinically suspected competing country driving ECMO effective Effectiveness eligible patient estimate event extracorporeal membrane oxygenation FIVE Follow-up fraction hospital hypoxaemia intensity intensive care Laboratory mechanical ventilation Mortality observational study outcome oxygen PaO Patient Primary outcome Probability reduction in mortality Respiratory failure risk SARS-COV-2 infection Secondary analyses selected severity Treatment Treatment effectiveness Weighting [DOI] 10.1136/bmj-2021-068723 PMC 바로가기 [Article Type] Observational Study