Generative artificial intelligence to produce high-fidelity blastocyst-stage embryo imagesOriginal Article Embryology Published on 2024-06-102024-09-05 Journal: Human Reproduction [Category] update2024, [키워드] artificial intelligence assisted reproductive technology embryo images embryogenesis generative adversarial networks Image processing IVF reproductive medicine time-lapse microscopy [DOI] 10.1093/humrep/deae064 PMC 바로가기 [Article Type] Original Article Embryology
Identification of side effects of COVID-19 drug candidates on embryogenesis using an integrated zebrafish screening platformarticle Published on 2023-10-092024-09-05 Journal: Burma Med J [Category] update2024, [키워드] Disease model embryogenesis heart development phenotypic screening zebrafish [DOI] 10.1038/s41598-023-43911-3 PMC 바로가기 [Article Type] article
Single-cell analysis reveals transcriptomic and epigenomic impacts on the maternal–fetal interface following SARS-CoV-2 infectionarticle Published on 2023-07-032024-09-05 Journal: Nature cell biology [Category] update2024, [키워드] embryogenesis epigenomics [DOI] 10.1038/s41556-023-01169-x PMC 바로가기 [Article Type] article
Sex-biased expression of the TLR7 gene in severe COVID-19 patients: Insights from transcriptomics and epigenomicsArticle Published on 2022-12-012022-11-16 Journal: Environmental research [Category] 유전자 메커니즘, [키워드] acute phase analyzed Blood Cohort coronavirus disease COVID-19 COVID-19 patient CpG DNA DNA methylation dose downregulated embryogenesis epidemiological data epigenomic epigenomics Evidence expression female females gene product Genetic variation Genome-wide association studies Host inactivation incidence incidence of COVID-19 independent insight long-COVID-19 male males Methylation n-Counter. nasal patients Post-infection RNAseq Saliva Severe case severe COVID-19 severity Sex significantly higher stratified suggested timepoint TLR7 TLR7 gene transcriptomics with COVID-19 [DOI] 10.1016/j.envres.2022.114288 PMC 바로가기
Molecular diversity and phenotypic pleiotropy of ancient genomic regulatory loci derived from human endogenous retrovirus type H (HERVH) promoter LTR7 and HERVK promoter LTR5_Hs and their contemporary impacts on pathophysiology of Modern HumansArticle Published on 2022-11-012022-11-15 Journal: Molecular genetics and genomics : MGG [Category] SARS, 유전자 메커니즘, 진단, [키워드] affected Analysis Ape apes azoospermia Brain brain regions Cancer Cell cell type cells Central nervous system cognitive Consensus conserved coronavirus COVID-19 COVID-19 pandemic database defined disorders DNA sequence dominant element embryogenesis event Evidence Evolution expressed expression fetal functional gene signature Genes genes encoding Genome genomic germline global pandemic Glutamatergic GSEA HERV HERVs Human human cell Human embryogenesis human endogenous retrovirus Human endogenous retrovirus type H (HERVH) Human endogenous retrovirus type K (HERVK) human physiology Human spermatogenesis identification Impact implicated include Infection inheritance insertion Interaction Lineage loci LTR LTR5_Hs LTR7 subfamilies majority mammalian Mammalian offspring survival genes marker Metastasis Monkey morphological feature morphologically MOS naïve neoplasm Neoplasm metastasis Neural Neuron neurons New World non-human primates observation offspring Oligospermia pathogen pathology pathophysiology Phenotypes phenotypic physiological Pleiotropy Population population-level effect primate Primate evolution promoter protein-protein interaction Protein–protein interactions at synapses proteomics Quantitative Radial rare disease recessive regulated Regulatory regulatory element regulatory sequence Release replicate representing Retrotransposition retroviral retrovirus SARS-CoV-2 SARS-CoV-2 coronavirus Schizophrenia sequence significantly Spread Stage survival synaptic Synaptic transmission Synaptic transmission. target the SARS-CoV-2 timeline traits Transmission trigeminal undergo viral genome viral infection viral infections virus viruses [DOI] 10.1007/s00438-022-01954-7 PMC 바로가기
SARS-CoV-2 can infect human embryosArticle Published on 2022-09-142022-11-15 Journal: Scientific Reports [Category] SARS, 치료기술, 치료제, [키워드] ACE2 antibody canonical Cell cell entry cells co-expressed COVID-19 COVID-19 pandemic Effect Embryo embryogenesis embryos Factor fluorescent glycoprotein Health human tissue identify immunofluorescence implicated implication infect Infection observé organ pandemic Pregnancy reporter reproductive resulting RNA-Seq robust SARS-CoV-2 SARS-COV-2 infection spike Spread susceptibility susceptible Symptom target tissue TMPRSS2 viral entry virions pseudotyped [DOI] 10.1038/s41598-022-18906-1 PMC 바로가기
Sonic hedgehog pathway for the treatment of inflammatory diseases: implications and opportunities for future research염증성 질환 치료를 위한 음파 고슴도치 경로: 향후 연구를 위한 의미 및 기회Editorial Published on 2022-06-012022-09-11 Journal: Journal for immunotherapy of cancer [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Activation acute myeloid leukemia Airway inflammation allergy Arthritis Asthma atopic dermatitis Autoimmune diseases Basal cell basal cell carcinoma Breast cancer Cancer cancer development cancers Cell cellular response component conserved COVID-19 Crohn's disease different diseases disease drugs dysregulation embryogenesis Factors glioma homolog Host human body immune dysregulation immune response immune system evasion implication Infection infections Inflammation Inflammation mediators Inflammatory Influenza inhibit investigated involved lung carcinoma malignancies mechanism medulloblastoma Mutation Pancreatic cancer pathogen pathogen-mediated pathogenic pathway progression receptor receptor inhibitor Research rheumatoid arthritis SARS-CoV-2 viruses shifting signaling pathway targets Therapeutic approach therapeutic strategy tissue homeostasis transcriptional treat Treatment tumors [DOI] 10.1136/jitc-2021-004397 PMC 바로가기 [Article Type] Editorial
Population genomics and geographic dispersal in Chagas disease vectors: Landscape drivers and evidence of possible adaptation to the domestic setting차가스 질병 벡터의 인구 유전체학 및 지리적 분산 : 국내 환경에 대한 조경 동인 및 가능한 적응의 증거Research Article Published on 2022-02-042022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adopted approach approaches Chagas disease Community directional disease disease control dispersal disperse driver Drivers Ecuador effective Elevation embryogenesis evaluated Evidence evidence of evidenced facilitate forest gene flow Genome genomic genomic region identify indicate infestation Intervention involved landscape Local loci mapped occur outlier Population population genomics provided reactive repeated Research Rhodnius Saliva Sequencing Seven SNP marker SNP markers vector vector control zone [DOI] 10.1371/journal.pgen.1010019 PMC 바로가기 [Article Type] Research Article
ROS/RNS Balancing, Aerobic Fermentation Regulation and Cell Cycle Control – a Complex Early Trait (‘CoV-MAC-TED’) for Combating SARS-CoV-2-Induced Cell ReprogrammingImmunology Published on 2021-07-072022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, SARS, [키워드] aerobic fermentation alternative oxidase Anti-viral AOX approach balancing Cell condition Control Critical cycle de novo disease domain effort embryogenesis extension fermentation handling highlight homeostasis Hypothesis identify in vitro initiated lab melatonin mTOR observation Perspective plant plants profile profiles programming progression Prophylactic raised redox biology reprogramming repurposing drugs Research SARS-CoV-2 SARS-COV-2 infection selected Stress survival target gene Therapeutic strategies transcript Transcriptome tubulin variant viral infection virus [DOI] 10.3389/fimmu.2021.673692 PMC 바로가기 [Article Type] Immunology
From Plant Survival Under Severe Stress to Anti-Viral Human Defense – A Perspective That Calls for Common Efforts심한 스트레스를 받는 식물 생존에서 항바이러스 인간 방어까지 – 공동의 노력이 필요한 관점Immunology Published on 2021-06-152022-09-12 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, [키워드] administration aerobic fermentation alternative oxidase alternative oxidase (AOX) Anti-viral Anti-viral therapy applied approach attack Cell cells combating common complex Critical de novo develop early cell reprogramming embryogenesis explain Genes highlighting Human Hypothesis identify in vitro knowledge organism Perspective plant profile programming promote reprogramming ReprogVirus Resilience SARS-CoV-2 selected somatic embryogenesis Stress stress tolerance Support survival target gene transcript turn Viral diseases virus virus attacks virus-infected cell [DOI] 10.3389/fimmu.2021.673723 PMC 바로가기 [Article Type] Immunology