Bio-efficacy of insecticidal molecule emodin against dengue, filariasis, and malaria vectorsarticle Published on 2023-05-312024-09-01 Journal: Environmental Science and Pollution Research International [Category] 말라리아, [키워드] Artemia nauplii Aspergillus terreus Danio rerio emodin Mosquitocidal odorant binding proteins [Article Type] article
In Silico Screening of Natural Products as Potential Inhibitors of SARS-CoV-2 Using Molecular Docking Simulation분자 도킹 시뮬레이션을 사용한 SARS-CoV-2의 잠재적 억제제로서의 천연물 스크리닝Article Published on 2022-03-012022-09-11 Journal: Chinese journal of integrative medicine [Category] SARS, 치료제, [키워드] 3CL 3CL pro ABL1 acting activated acute respiratory syndrome acute respiratory syndrome coronavirus angiotensin angiotensin converting enzyme anti-SARS-CoV-2 berbamine betulinic acid binding affinity calcineurin carried Cepharanthine chymotrypsin Chymotrypsin-like protease Compound compounds coronavirus derivative drug emodin enzyme glucogallin homolog human coronaviruses in-silico juglanin leukemia molecular molecular docking molecular docking studies Molecular docking study MOST murine natural natural products-derived anti-SARS-CoV-2 candidates NFAT non-structural protein nonstructural proteins nsp10 nsp13 nsp14 Nsp15 Other Papain Papain-like protease performed Potential product protease Protein quercetin RdRP receptor RNA-dependent RNA polymerase S protein SARS-CoV-2 screened Screening Serine serine 2 severe acute respiratory syndrome Coronavirus Simulation spike glycoprotein structural proteins T-cell T-cells tanshinone tanshinone I target target protein target proteins these compound these compounds transmembrane [DOI] 10.1007/s11655-021-3504-5 PMC 바로가기 [Article Type] Article
Exploration of the Mechanism of Lianhua Qingwen in Treating Influenza Virus Pneumonia and New Coronavirus Pneumonia with the Concept of “Different Diseases with the Same Treatment” Based on Network PharmacologyResearch Article Published on 2022-02-082022-10-31 Journal: Evidence-based Complementary and Alternative Medicine : eCAM [Category] COVID-19, [키워드] 3CL ACE2 angiotensin-converting enzyme 2 Apoptosis binding biological process biological processes cell proliferation component components concept COX2 cytokine Cytoscape database DAVID docking docking result emodin enrichment analysis exploration FIVE IL-17 IL-6 immune system Influenza virus interleukin-6 Intervention Invasion involved KEGG Kyoto Luteolin MAPK mechanism metabolism Necrosis network New Novel coronavirus Occurrence Ontology pathway Pathway enrichment analysis Pathways Pharmacology Pneumonia protease Protein quercetin Regulation Result rutin screened Seven T cell receptor target targets TNF Toll-like receptor treating Treatment was used [DOI] 10.1155/2022/5536266 PMC 바로가기 [Article Type] Research Article
Photodynamic Inactivation of Human CoronavirusesArticle Published on 2022-01-082022-10-28 Journal: Viruses [Category] COVID-19, [키워드] absence Antiviral antiviral activity Antiviral effect antiviral property assays Betacoronavirus concentrations coronavirus CoVs cultured cell damaged demonstrated digestion dose-dependent manner doses emodin expand experiments HCoV-229E HCoV-OC43 herpes simplex Human human cells human coronavirus inactivation inhibited lentivirus Local microorganisms natural product oxygen PDI photodynamic inactivation photosensitizer PhytoQuin prevented Protein pseudotyped reactive oxygen specy Replication RNase ROS S protein SARS-CoV-2 spike susceptible the SARS-CoV-2 Viral RNA virus viruses [DOI] 10.3390/v14010110 PMC 바로가기 [Article Type] Article
Amantadine inhibits known and novel ion channels encoded by SARS-CoV-2 in vitroArticle Published on 2021-12-012022-10-04 Journal: Communications Biology [Category] SARS, 신약개발, 치료제, [키워드] amantadine anti-influenza drug approved drugs binding block cellular clinical study conserved Coronaviruses COVID-19 COVID-19 patients COVID-19 treatment derivative Effect emodin evaluated expression identify in vitro indicated inhibit inhibitor ion channel blocker molecular molecular basis Molecular medicine NMR Oocyte ORF10 ORF7b pathophysiology SARS-CoV-2 suggested target Treatment viral infection Xanthene [DOI] 10.1038/s42003-021-02866-9 PMC 바로가기 [Article Type] Article
Antiviral Activities of Halogenated Emodin Derivatives against Human Coronavirus NL63Article Published on 2021-11-112022-10-30 Journal: Molecules [Category] COVID-19, MERS, [키워드] 1,3,8-trihydroxy-6-methylanthracene-9,10-dione activity analogue antiviral activities antiviral activity comparable coronavirus COVID-19 COVID-19 outbreak derivative derivatives drug effective electrophilic emodin generate halogenated emodin HCoV-NL63 human coronavirus human coronavirus NL63 Imatinib IMPROVE initial Modification natural NL63 plant plants reaction Remdesivir respiratory SAR SARS-CoV-2 significantly Toxicity Treatment Vaccine Vero cells Viral diseases [DOI] 10.3390/molecules26226825 PMC 바로가기 [Article Type] Article
Detecting SARS-CoV-2 Orf3a and E ion channel activity in COVID-19 blood samplesResearch Article Published on 2021-09-142022-10-30 Journal: Journal of Clinical and Translational Science [Category] COVID-19, [키워드] 4-aminopyridine absence Blood blood circulation blood sample channel activity detection Concordance COVID-19 COVID-19 infected patients COVID-19 patients detect emodin Hypothesis increase in individuals inhibited Myocardium other organ positive potassium ion SARS-CoV-2 SARS-CoV-2 ORF3a upper respiratory tract virus virus spread [DOI] 10.1017/cts.2021.856 PMC 바로가기 [Article Type] Research Article
Reynoutria Rhizomes as a Natural Source of SARS-CoV-2 Mpro Inhibitors–Molecular Docking and In Vitro StudyArticle Published on 2021-07-292022-10-28 Journal: Pharmaceuticals [Category] COVID-19, [키워드] Polygoni cuspidati rhizoma Reynoutria sachalinensis acute lung injury acute respiratory syndrome antiviral activity binding site butanol China Chinese Compound coronavirus Coronavirus disease 2019 COVID-19 COVID-19 (Coronavirus disease 2019) docked drug Effect emodin explain fluorescent food fraction Fractions gallate H1N1 identify in vitro inhibitory moderate natural pandemic Patient peptide plant polymerized Prevent Proanthocyanidins provide Replication Research responsible resveratrol rhizome SARS-CoV-2 SARS-CoV-2 main protease SARS-CoV-2 Mpro Shu Source Spread Supportive treatment TCM tested Traditional treat Treatment vanicoside virus [DOI] 10.3390/ph14080742 PMC 바로가기 [Article Type] Article
Drugs repurposed for COVID-19 by virtual screening of 6,218 drugs and cell-based assay6,218 개의 약물 및 세포 기반 분석의 가상 스크리닝에 의해 Covid-19에 대한 용도가 변경된 약물408 Published on 2021-07-272022-08-31 Journal: Proceedings of the National Academy of Sciences of [Category] 신약개발, 치료제, [키워드] anti-SARS-CoV-2 activities Anti-SARS-CoV-2 Activity antiviral agent Antiviral agents antiviral drug antiviral drugs antiviral efficacy applied approach approved approved drug approved drugs Calu Calu-3 caused cell-based assay clinical trial clinically Compound Computational methods concentrations COVID-19 COVID-19 pandemic docking docking-based virtual screening drug drug combination drug combinations Drug repurposing drugs Effect Efficacy emodin False positive False positives Health human Calu-3 cells human lung cells IMPROVE infectious viruses inhibit SARS-CoV-2 inhibiting Interaction omipalisib predicted protease recent reduce reduced Remdesivir Replication reported Repurposed drugs resulting risk RNA-dependent RNA polymerase SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication screened Seven Significance similarity Spread synergistic synergistic effects therapy tipifarnib Toxicity treating COVID-19 Treatment Vero cells Virtual screening viruses [DOI] 10.1073/pnas.2024302118 PMC 바로가기 [Article Type] 408
Revealing the therapeutic targets and molecular mechanisms of emodin-treated coronavirus disease 2019 via a systematic study of network pharmacology네트워크 약리학에 대한 체계적인 연구를 통해 2019 년 에모딘 처리 된 코로나 바이러스 질병의 치료 표적 및 분자 메커니즘을 드러냅니다.Research Paper Published on 2021-06-152022-09-10 Journal: Aging (Albany NY) [Category] 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 B-cell B-cell lymphoma Bacterial BCL2L1 bioinformatics Biomarker Biomarkers Cancer candidate gene CASP3 caspase caspase-3 colony stimulating factor complications coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 CSF2 CXCL8 developmental Diabetic diabetic complications docking Effect EGFR emodin endothelial epidermal epidermal growth factor exhibited Factor GO analysis growth factor IL-17 IL1B Infection interleukin interleukin-8 involved KEGG leads lipopolysaccharide MAPK MAPK signaling MAPK1 MAPK14 MCL1 mitogen mitogen-activated protein kinase molecular molecular docking molecular mechanism molecular mechanisms molecule myeloid cell Necrosis network pharmacology pathway Pathways pertussis pharmacological pharmacological mechanism pharmacological target Protein protein kinase Proteoglycan proteoglycans PTGS2 RAGE receptor receptor signaling reproduction reproductive respiratory screened severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 shown signaling pathway suggested target targets therapeutic target TNF TNF signaling TP53 treating COVID-19 Treatment treatment of COVID-19 Tumor tumor necrosis tumor necrosis factor Vascular VEGFA [DOI] 10.18632/aging.203098 PMC 바로가기 [Article Type] Research Paper