Highly sensitive aptasensor for the detection of SARS-CoV-2-RBD using aptamer-gated methylene blue@mesoporous silica film/laser engraved graphene electrodeArticle Published on 2022-11-012022-11-15 Journal: Biosensors & bioelectronics [Category] COVID19(2023년), SARS, 치료기술, [키워드] absence acute respiratory syndrome Analysis aptamer Aptamer gated-mesoporous silica film aptasensor C-reactive protein Coronavirus-2 Coverage detect Electrochemical measurement electrostatic encapsulation group high affinity indicated influenza A virus limit of detection phosphate porous probe Saliva SARS-CoV-2-RBD SARS-CoV-2-RBD. the receptor-binding domain was recorded [DOI] 10.1016/j.bios.2022.114556 PMC 바로가기
A lipid nanoparticle platform for mRNA delivery through repurposing of cationic amphiphilic drugsResearch article Published on 2022-10-012022-10-05 Journal: Journal of controlled release : official journal o [Category] 신약개발, [키워드] addition approach approval bovine CAD cancer cell cationic Cationic amphiphilic drugs Cationic lipid Cell Cellular delivery component Corneal COVID-19 mRNA vaccines drug drug combination Drug repurposing Efficiency encapsulation epithelial cell epithelial cells eyes functional healthcare HeLa cell in vitro in vivo Lipid lipid component Lipid nanoparticles Liposome LNP maintain Messenger RNA mRNA nanomedicine Patient pharmacological platform primary cell RNA RNA therapeutics selected small molecule drug subsequent Therapies Vesicle was obtained [DOI] 10.1016/j.jconrel.2022.08.009 [Article Type] Research article
Liposome encapsulated clodronate mediated elimination of pathogenic macrophages and microglia: A promising pharmacological regime to defuse cytokine storm in COVID-19Review article Published on 2022-09-012022-10-05 Journal: Medicine in Drug Discovery [Category] 신약개발, 치료제, [키워드] activated macrophage Activation administration adverse effect alleviate Brain Clinical management Clodronate COVID-19 COVID-19 vaccine COVID-19 vaccines Cytokine storm death depleting discharge dysregulation encapsulation event Factor Host immune response immunogenic reaction immunological induce Inflammation life-threatening Liposomal clodronate Liposome Macrophage microglia microglial microglial cell Mortality multiorgan failure new SARS-CoV-2 offer pathogenic phagocytic cell pharmacological positive proinflammatory public health reactive reported resulting SARS-CoV-2 infected individuals SARS-COV-2 infection therapeutic strategy variant while [DOI] 10.1016/j.medidd.2022.100136 [Article Type] Review article
Modulating Fingolimod (FTY720) Anti-SARS-CoV-2 Activity Using a PLGA-Based Drug Delivery SystemArticle Published on 2022-07-182022-10-04 Journal: ACS applied bio materials [Category] COVID19(2023년), SARS, 신약개발, [키워드] activity Anti-SARS-CoV-2 Activity Antiviral antiviral activity cell line Combination concentrations confocal microscopy COVID-19 COVID-19 case Cytometry death delivery develop Disease progression drug Drug repurposing encapsulation exhibit fingolimod Flow FTY720 less Lysosomes macropinocytosis nanoparticle Nanotechnology. occur pathway PLGA PLGA-based nanoparticles reduce Safe System therapy for COVID-19 Toxicity Treatment Vaccine viral infection Viral transmission [DOI] 10.1021/acsabm.2c00349 PMC 바로가기 [Article Type] Article
Lung targeted liposomes for treating ARDSARDS 치료를 위한 폐 표적 리포솜Article Published on 2022-06-012022-09-11 Journal: Journal of controlled release : official journal o [Category] 치료제, [키워드] accumulate accumulation acute respiratory distress acute respiratory distress syndrome Administered administration alveolar approach ARDS BAL Bronchoalveolar lavage C57BL/6 characterized combined treatment COPD COVID-19 COVID-19 infections cysteine cytokine secretion distal DPPC drug Efficiency encapsulation endotracheal exhibited Gas exchange Hypoxemia IL-1β IL-6 impair infections Inflammation Inflammatory marker inflammatory markers intravenous intravenously lipid composition Lipid nanoparticles lipopolysaccharide Liposome lung lung damage Lung diseases lung disorders lung endothelial lung epithelial Lung inflammation Lungs Macrophage macrophages marker medication Methylprednisolone mice mortality rate mortality rates MPS mucolytic agent Mucus N-acetyl cysteine NAC nanoparticle Nanotechnology nitric oxide outcome Patient penetration provided pulmonary Pulmonary. reached reduce reducing Region respiratory respiratory distress Respiratory distress syndrome secretion steroid syndrome therapeutic therapeutic effect therapeutic efficacy TNFα Treatment Treatment outcome were assessed [DOI] 10.1016/j.jconrel.2022.03.028 PMC 바로가기 [Article Type] Article
Biological and Immune Responses to Current Anti-SARS-CoV-2 mRNA Vaccines beyond Anti-Spike Antibody ProductionAnti-Spike 항체 생산을 넘어 현재의 Anti-SARS-CoV-2 mRNA 백신에 대한 생물학적 및 면역 반응Review Published on 2022-05-142022-09-11 Journal: Journal of Immunology Research [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] administration anti-SARS-CoV-2 vaccines anti-spike antibodies antibodies antibody waning antiviral antibodies appear Biological booster carried Cell clinical observation coding current disease distribution effective Efficiency emergence encapsulation Express Factor help immune system Infection injected intramuscularly lack mass vaccination memory B cell memory B cells mRNA not limited oral mucosa pandemic plasma membrane Production PROTECT Protein response RNA molecules RNA virus SARS-COV-2 infection SARS-CoV-2 pandemic SARS-CoV-2 spike protein spike Spike protein the SARS-CoV-2 the Spike tissue vaccination Vaccine Viral viral variant Viral variants virtue [DOI] 10.1155/2022/4028577 PMC 바로가기 [Article Type] Review
Airway Delivery of Hydrogel-Encapsulated Niclosamide for the Treatment of Inflammatory Airway DiseaseArticle Published on 2022-01-192022-10-29 Journal: International Journal of Molecular Sciences [Category] Coronavirus, [키워드] activated administration Affect airway airway epithelial cell airway epithelium anthelminthic applied Asthma asthmatic Calu-3 cells chronic obstructive circumvent CLCA1 clearance comparable Compound COVID-19 delivery disease drugs Effect effective encapsulation Ex vivo examined explained fibrosis glycol human airway epithelial hydrospheres in vitro in vivo Inflammatory inflammatory airway disease Influenza inhibit inhibited inhibitory effect intratracheal instillation Local mice Nanospheres niclosamide pro-inflammatory problems proinflammatory pulmonary disease repurposing respiratory syncytial virus SARS-CoV-2 secretion Side effects TMEM16A TMEM16F Trachea tracheas Treatment viral respiratory infections were assessed while [DOI] 10.3390/ijms23031085 PMC 바로가기 [Article Type] Article
A Dispersion Corrected DFT Investigation of the Inclusion Complexation of Dexamethasone with β-Cyclodextrin and Molecular Docking Study of Its Potential Activity against COVID-19β-Cyclodextrin과 Dexamethasone의 포함 복합체에 대한 분산 수정 DFT 조사 및 COVID-19에 대한 잠재적 활성에 대한 분자 도킹 연구Article Published on 2021-12-152022-09-10 Journal: Molecules [Category] SARS, 치료제, [키워드] β-cyclodextrin 6LU7 active site active sites activity approach AutoDock AutoDock vina binding Bioavailability calculated Cavity characterization complex complexation computation COVID-19 Density functional theory Dexamethasone DFT-D4 dispersion encapsulation ENhance free energy functional hydrogen Hydrogen bond hydrogen bonds inhibitor inhibitory activity Interaction investigated investigation molecular docking Molecular docking study non-covalent interactions PDB PDB ID PDB ID: 6LU7 Potential predicted protease Protease inhibitor Protein reducing SARS CoV-2 Side effects significantly target protein therapeutic activity van der Waal van der Waals interactions was performed [DOI] 10.3390/molecules26247622 PMC 바로가기 [Article Type] Article
Successful Treatment of Acute Myeloid Leukemia with CPX-351 in 2 Patients in the United Kingdom during the COVID-19 PandemicConference abstract Published on 2021-11-232022-10-05 Journal: Blood [Category] 치료법, [키워드] Administered AML appropriate patient approved Asymptomatic benefit blood count Bone marrow change Chemotherapy Comorbidity Complete complications consolidation COVID-19 COVID-19 infection COVID-19 pandemic CPX-351 curative intent Day declined demonstrated Diabetic diagnosed disease download drug history eligible encapsulation Europe fatigue female figure FLT3 group hemoglobin IDH2 Immunocompromised patients Immunosuppression Infection infection rate Intensive IV infusion Jazz male mutated Mutation myeloid myelosuppression nephropathy neutropenic sepsis neutrophil neutrophil count NPM1 occurred pandemic Patient PCR swab Pediatric patient Platelet positive receiving remained risk risk factor Sepsis significantly speaker SRSF2 Symptom synergistic the disease the patient The United States Tolerability treated Treatment Two patient type 2 diabetes United Kingdom White blood cell wild-type working [DOI] 10.1182/blood-2021-146524 [Article Type] Conference abstract
Polymer-Based Nanosystems—A Versatile Delivery ApproachReview Published on 2021-11-112022-10-30 Journal: Materials [Category] COVID-19, [키워드] carrier Concentration Degradation delivery drug clearance drug delivery drugs encapsulation Genes immunomodulatory property inherent linear morphology novel nanocarriers Polymer polymer-based nanoparticles raised reduce stability sustained Targeted delivery Vaccine Vaccine adjuvants vaccine delivery Vaccine development [DOI] 10.3390/ma14226812 PMC 바로가기 [Article Type] Review