Construction and evaluation of a self-replicative RNA vaccine against SARS-CoV-2 using yellow fever virus repliconArticle Published on 2022-10-202022-11-15 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 진단, [키워드] acute respiratory syndrome antibody Antigen C57BL/6 caused cells co-expressed construction coronavirus coronavirus disease COVID-19 effective vaccine Efficacy Electroporation elicit ENCODE ENhance evaluated Fever gene encoding Host host genome immune response Immunity IMPROVE Infection Innate immunity kidney mice mRNA vaccine pandemic Protein qRT-PCR Replication replicon responses RNA RNA vaccine robust S protein expression Safe SARS-CoV-2 significantly higher single dose Specific T-cell response T-cell Response the S protein Vaccine vaccine administration vaccine platform virus [DOI] 10.1371/journal.pone.0274829 PMC 바로가기
Structural investigations of proteins encoded by SARS-CoV-2Article Published on 2022-09-012022-11-16 Journal: FEBS Open Bio [Category] SARS, 변종, 유전자 메커니즘, [키워드] antibodies articles bases categories cellular cleaved commenced coronavirus COVID COVID-19 pandemic cysteine proteases described ENCODE Evolution example expressed Final Genome include knowledge MN908947.3 molecular mechanism other coronaviruses pandemic polyprotein positive-sense Protein protein structure purified reported Research ribonuclease RNA genome RNAs SARS-CoV-2 selected sequenced single-stranded small molecule drugs Spike protein structural property the disease the spike protein translation Vaccines variant viral transcript were expressed [DOI] 10.1002/2211-5463.13465 PMC 바로가기
SARS-CoV-2 ORF6 disrupts innate immune signalling by inhibiting cellular mRNA exportArticle Published on 2022-08-252022-11-15 Journal: PLoS Pathogens [Category] SARS, 유전자 메커니즘, 치료제, [키워드] accessory proteins affected Antiviral antiviral responses Betacoronavirus blocked caused Cell cellular COVID-19 disrupt ENCODE etiological agent expression Factor Health host cell identify in vitro Infectious disease inhibit inhibiting innate immune interact Interaction IRF1 mechanism modulating Molecular biology mRNA mRNA export ORF6 predicted Protein Replication RIG-I SARS-CoV-2 SARS-COV-2 infection supress utilised viral replication virus [DOI] 10.1371/journal.ppat.1010349 PMC 바로가기
Roles and functions of SARS-CoV-2 proteins in host immune evasion숙주 면역 회피에서 SARS-CoV-2 단백질의 역할과 기능Review Published on 2022-08-082022-09-11 Journal: Frontiers in Immunology [Category] SARS, 치료법, [키워드] accessory protein accessory proteins activator acute respiratory syndrome acute respiratory syndrome coronavirus coronavirus described ENCODE evade Frame function functions Genome Host host immune system IFN-β IFNs immune immune evasion inhibiting interferon interferons IRF3 mechanism mechanisms NF-κB nine non-structural protein non-structural proteins nsp1 Nsp12 nsp13 nsp14 Nsp15 nsp5 NSP6 NSP8 Nsps nuclear nuclear translocation Open reading frame ORF10 ORF3b ORF6 ORF8 Orf9b Perspective Phosphorylation Protein Regulatory role SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 proteins severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Signaling STAT2 STATs structural proteins suppress TBK1 Transcription type I type I and III interferons variety Viral protein Viral proteins [DOI] 10.3389/fimmu.2022.940756 PMC 바로가기 [Article Type] Review
Heterologous saRNA Prime, DNA Dual-Antigen Boost SARS-CoV-2 Vaccination Elicits Robust Cellular Immunogenicity and Cross-Variant Neutralizing Antibodies이종 saRNA 프라임, DNA 이중 항원 부스트 SARS-CoV-2 백신 접종으로 강력한 세포 면역원성과 교차 변형 중화 항체 유도Article Published on 2022-07-152022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료법, [키워드] Adenovirus animal model animal models B.1.617.2 Beta boost CD4+ CD8+ T-cell combinations COVID-19 D614G mutation Delta distribution DNA dual dual antigen ENCODE enhanced expression followed by furin furin cleavage region Glutamine Heterologous highest homologous homologous or heterologous Humoral response humoral responses IgG immune response immune responses immunogenicity lipid carrier MHC class I MHC class I and II mice motif N antigen Neutralizing nucleic acid nucleocapsid omicron peptide peptides prefusion conformation prime proline prolines protease pseudovirus receiving regimen regimens Region response RNA vaccine SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant self-amplifying RNA sequence sera serotype spike Stimulation strain Strains Support T-cell T-cell responses vaccination Vaccine Vaccines variant wild type Wuhan [DOI] 10.3389/fimmu.2022.910136 PMC 바로가기 [Article Type] Article
Rational development of a combined mRNA vaccine against COVID-19 and influenza Research Published on 2022-07-012022-10-05 Journal: NPJ Vaccines [Category] 임상, 진단, 치료기술, 치료법, [키워드] Antigen Cellular immune response characterized clinical outcomes COVID-19 COVID-19 pandemic Delta demonstrated dose elicited ENCODE Final H1N1 highlight IAV immunization Influenza influenza A influenza A virus mice morbidity and mortality mRNA vaccine platform Protective antibody RBD respiratory diseases robust S protein SARS-CoV-2 Seasonal influenza the receptor-binding domain the SARS-CoV-2 Vaccine vaccine platform variants virus [DOI] 10.1038/s41541-022-00478-w [Article Type] Research
Human ACE2 Polymorphisms from Different Human Populations Modulate SARS-CoV-2 Infection다양한 인간 집단의 인간 ACE2 다형성이 SARS-CoV-2 감염을 조절합니다Article Published on 2022-06-302022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 variant ACE2 variants acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect Asian caused cell entry receptor cells contrary coronavirus COVID-19 COVID-19 mortality COVID-19 pandemic COVID-19 symptom COVID-19 symptoms death determinant E35K ENCODE environmental factor Ethnic groups expression Genetic genetic determinant hACE2 high variability Host Human human ACE2 Human genome human population Infection modulate pandemic polymorphism Polymorphisms Population populations PROTECT Protective protective effect reduced risk SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe COVID-19 severity of COVID-19 surface expression susceptibility Symptoms two allele Two alleles variant virus infection wild-type [DOI] 10.3390/v14071451 PMC 바로가기 [Article Type] Article
Neutralizing Potency of Prototype and Omicron RBD mRNA Vaccines Against Omicron Variant오미크론 변이체에 대한 프로토타입 및 오미크론 RBD mRNA 백신의 중화 효능Article Published on 2022-06-302022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Against Antisera booster CD4 coronavirus Delta domain dose effective effective vaccine Effective vaccines Efficacy ENCODE expressing feasibility Heterologous heterologous immunization highlighting IFN-γ IL-2 immunization immunization program increase in induce information mice mRNA mRNA vaccine Mutation neutralization neutralization titer neutralization titers Neutralizing Neutralizing antibodies neutralizing antibody omicron Omicron variant opposite potency prototype RBD Receptor binding domain Receptor-binding domain respiratory SARS-CoV-2 SARS-CoV-2 vaccine severe acute respiratory syndrome Coronavirus significantly Spike protein Strains T cell T cell response T cell responses the RBD the spike protein urgency Vaccine Vaccines variant wildtype [DOI] 10.3389/fimmu.2022.908478 PMC 바로가기 [Article Type] Article
Nucleopore Traffic Is Hindered by SARS-CoV-2 ORF6 Protein to Efficiently Suppress IFN-β and IL-6 SecretionIFN-β 및 IL-6 분비를 효율적으로 억제하기 위해 SARS-CoV-2 ORF6 단백질에 의해 핵공 이동이 방해됨Article Published on 2022-06-112022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Activation addition antagonistic antiviral response block cascade characterized clinical outcomes contributing to counteract Critical cytokine Cytokines cytoplasm cytoplasmic demonstrated ENCODE exacerbated Factors feature Genes Host host immune system IFN-β IL-6 immune immune evasion Infection Inflammation interferon interferon antagonist interleukin interleukin-6 MAVS MDA-5 mechanism Messenger RNA movement mRNA multifunctional NF-κB not affected novel SARS-CoV-2 virus nuclear translocation nucleus occurred ORF6 pro-inflammatory cytokine pro-inflammatory cytokines Protein reported RIG-I SARS-CoV-2 SARS-CoV-2 ORF6 protein SARS-CoV-2 virus Signaling STAT suppresse suppression the SARS-CoV-2 Traffic transcription factor transcription factors transcriptional viral infection viral pathogenesis virulence virus [DOI] 10.3390/v14061273 PMC 바로가기 [Article Type] Article
Of mice and human-specific long noncoding RNAs마우스 및 인간 특이적 긴 비암호화 RNAReview Published on 2022-06-012022-09-11 Journal: Mammalian genome : official journal of the Interna [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE2 gene acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 approach BAC Bacterial bacterial artificial chromosome Cell culture cell culture system cell culture systems chromosome complement conducted coronavirus coronavirus disease Coronavirus disease-19 COVID-19 effort ENCODE etiologic agent example exceeded Genome highlight in vivo integration lncRNA long noncoding RNA mechanism mice MOST mouse offer pandemic protein-coding genes random receptor Regulation SARS-CoV-2 severe acute respiratory syndrome Coronavirus upstream Vascular [DOI] 10.1007/s00335-022-09943-2 PMC 바로가기 [Article Type] Review