Endoplasmic reticulum localized TMEM33 domain-containing protein is crucial for all life cycle stages of the malaria parasitearticle Published on 2024-04-302024-09-01 Journal: Molecular Microbiology [Category] 말라리아, [키워드] autophagy drug resistance Endoplasmic reticulum malaria Plasmodium berghei TMEM33 [Article Type] article
Benzomorphan and non-benzomorphan agonists differentially alter sigma-1 receptor quaternary structure, as does types of cellular stressOriginal Article Published on 2024-01-092024-09-05 Journal: Cellular and Molecular Life Sciences [Category] update2024, [키워드] Endoplasmic reticulum MAM Mitochondria neurodegenerative disorders sigma-1 receptor [DOI] 10.1007/s00018-023-05023-z PMC 바로가기 [Article Type] Original Article
Pharmaceutical agent cetylpyridinium chloride inhibits immune mast cell function by interfering with calcium mobilizationArticle Published on 2023-08-242024-09-05 Journal: Food and chemical toxicology : an international jo [Category] update2024, [키워드] antimicrobial calcium cetylpyridinium chloride cytoplasmic pH degranulation Endoplasmic reticulum inositol 1,4,5-triphosphate mast cell microtubule plasma membrane potential quaternary ammonium compound [DOI] 10.1016/j.fct.2023.113980 PMC 바로가기 [Article Type] Article
Heteromeric clusters of ubiquitinated ER-shaping proteins drive ER-phagyarticle Published on 2023-05-242024-09-05 Journal: Nature [Category] update2024, [키워드] autophagy Endoplasmic reticulum neurodegeneration Ubiquitylation [DOI] 10.1038/s41586-023-06090-9 PMC 바로가기 [Article Type] article
Collagen‐Specific HSP47 + Myofibroblasts and CD163 + Macrophages Identify Profibrotic Phenotypes in Deceased Hearts With SARS‐CoV ‐2 InfectionsBrief Communication Published on 2023-02-152024-09-05 Journal: Journal of the American Heart Association [Category] update2024, [키워드] Basic Science Research Biomarkers cardiac fibrosis Cell Signalling/Signal Transduction Clinical studies COVID‐19 Endoplasmic reticulum fibrosis heat shock proteins human autopsy Stress [DOI] 10.1161/JAHA.122.027990 PMC 바로가기 [Article Type] Brief Communication
SARS-CoV-2 Diverges from Other Betacoronaviruses in Only Partially Activating the IRE1α/XBP1 Endoplasmic Reticulum Stress Pathway in Human Lung-Derived CellsArticle Published on 2022-10-262022-11-15 Journal: mBio [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, 치료기술, [키워드] activate Activation activities activity acute respiratory syndrome betacoronaviruses Cell cellular change coronavirus country Critical death downstream Endoplasmic reticulum enzyme ER stress examined expression of gene functions Gene Expression HCoV-OC43 Host host cell host cells host immune system Human human cell human cells imperative individual induce infect Infection inhibit interact IRE1α pathway less limit MERS-CoV MHV Middle East molecular mechanism mRNA murine OC43 Other other coronavirus pathway Prevent processed Replication required Respiratory Coronavirus respiratory syndrome coronavirus Reticulum RNase SARS-CoV SARS-CoV-2 SARS-COV-2 infection severe respiratory disease signaling pathway similarity splice Spread Stress tested the interferon transcription factor Trigger unfolded protein response UPR Vaccine viral replication virus XBP1 [DOI] 10.1128/mbio.02415-22 PMC 바로가기
Endoplasmic reticulum secretory pathway: Potential target against SARS-CoV-2Article Published on 2022-10-152022-11-15 Journal: Virus research [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] accelerate acute respiratory syndrome approach approved benefit caused cell membrane Clinical use coronavirus Coronavirus disease 2019 COVID-19 death demonstrated dependent on drug effort Endoplasmic reticulum ERS pathway Extensive feasibility globe inhibitor New overcome pathway pharmacological Potential Protein protein translation regulatory agencies Replication resulting SARS-CoV-2 SARS-COV-2 infection secretory pathway shown suppress targeting the SARS-CoV-2 therapeutic option unfolded protein response virion [DOI] 10.1016/j.virusres.2022.198897 PMC 바로가기
Inhibition of major histocompatibility complex-I antigen presentation by sarbecovirus ORF7a proteinsArticle Published on 2022-10-112022-11-16 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] absence acute respiratory syndrome Affect Amino acid Antigen Antigen presentation biological activity caused CD8 Cell complex Coronavirus-2 Cytotoxic T cells dissemination down-regulation downregulating Endoplasmic reticulum expressed histocompatibility complex human populations immune responses Immunity induce infected with SARS-CoV-2 Infection inhibited inhibition mechanism MHC-I MHC-I down-regulation ORF7a orf7a protein peptide Peptide loading complex persistence physically prevented reduced sarbecovirus SARS-CoV SARS-CoV-2 T cells variety viral peptide Viral proteins [DOI] 10.1073/pnas.2209042119 PMC 바로가기
ORF8 protein of SARS-CoV-2 reduces male fertility in miceSARS-CoV-2의 ORF8 단백질은 쥐의 수컷 생식력을 감소시킵니다Article Published on 2022-09-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] abnormality accompanied acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Administered Analysis Antibody titer Antibody titers Betacoronavirus body weight can be used circulating Col1a1 convalescent patient coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cultured cells decreased expression dependent on Endoplasmic reticulum examined Food Intake Gene Expression genus genus Betacoronavirus Human in vivo indicated Infection infertility inhibited inhibitor injection male mice Morphological N-terminal observation Open reading frame open reading frames ORF8 ORF8 protein oxygen peptide peptide sequence plasma sample plasma samples Protein provide reactive oxygen specy reduce reproductive reproductive system respiratory SARS-CoV-2 secretion sequence severe acute respiratory syndrome Coronavirus signal peptide testes the patient translated vitality [DOI] 10.1002/jmv.27855 PMC 바로가기 [Article Type] Article
Repurposing the mitotic machinery to drive cellular elongation and chromatin reorganisation in Plasmodium falciparum gametocytes Research Published on 2022-08-272022-10-05 Journal: Nature Communications [Category] 신약개발, [키워드] cellular chromatin complex components cytoplasmic disrupt driven by Endoplasmic reticulum falciform involved kinetochore protein malaria membrane Microscopy microtubule organizing center microtubule-associated protein mitotic nuclear nuclear envelope nuclear membrane Plasmodium falciparum Prevent Protein Proteins repurposing [DOI] 10.1038/s41467-022-32579-4 [Article Type] Research