Cathepsin K deficiency prevented stress-related thrombosis in a mouse FeCl 3 modelOriginal Article Published on 2024-05-042024-09-05 Journal: Cellular and Molecular Life Sciences [Category] update2024, [키워드] Apoptosis Cathepsin K chronic stress endothelial injury thrombosis [DOI] 10.1007/s00018-024-05240-0 PMC 바로가기 [Article Type] Original Article
Prognostic value of von Willebrand factor and ADAMTS13 in patients with COVID-19: A systematic review and meta-analysisReview article Published on 2022-10-012022-10-05 Journal: Thrombosis research [Category] 바이오마커, 진단, [키워드] ADAMTS13 addition Admission Analysis analyzed Antigen cause cleaving Clinical outcome Coagulation Coagulopathy Cochrane Library cofactor coronavirus disease COVID-19 COVID-19 patient Critical database death deficiency defined Effect endothelial injury estimate fixed FVIII ICU immunothrombosis increase indicated intensive care involved Ligand Meta-analysis metalloproteinase Mortality motif no significant difference non-ICU non-survivor outcome outcomes Patient patients with COVID-19 performed plasma poor prognosis Prognosis protease Quantitative random Result risk SARS-CoV-2 searched severe disease course subgroup analysis survivor Survivors systematic review the Newcastle-Ottawa Scale variable von Willebrand factor vWF Web of Science [DOI] 10.1016/j.thromres.2022.08.017 [Article Type] Review article
The impact of platelets on pulmonary microcirculation throughout COVID-19 and its persistent activating factorsArticle Published on 2022-09-282022-11-15 Journal: Frontiers in Immunology [Category] 치료제, [키워드] activate activating addition aggregation antiplatelet Blood coagulation factor complex convalescent COVID-19 COVID-19 patients disease severity disorders endothelial injury Factor Gas exchange hypercoagulability hypercoagulable hypercoagulable states Hypoxemia hypoxia immune cells impaired lung function impairment incidence Inflammation Inflammatory mediators inhibiting Intervention intrinsic involved Lung function manifestation marker microvesicle Microvesicles Mild Mortality Phosphatidylserine Platelet platelet activation Platelets promote PROTECT pulmonary permeability pulmonary vasculitis reactivity reducing resulting risk severe cases stages the disease therapy Thromboembolism thrombosis thrombotic event tissue Treatment vessel walls with COVID-19 [DOI] 10.3389/fimmu.2022.955654 PMC 바로가기
Circulating Endothelial Cells: A New Possible Marker of Endothelial Damage in Kawasaki Disease, Multisystem Inflammatory Syndrome in Children and Acute SARS-CoV-2 InfectionArticle Published on 2022-09-032022-11-15 Journal: International Journal of Molecular Sciences [Category] SARS, 바이오마커, 치료기술, [키워드] acute COVID-19 Biomarker Cell CellSearch characterized children circulating circulating endothelial cells conducted coronary artery lesions correlation COVID-19 damage decrease disease Diseases endothelial Endothelial cell Endothelial dysfunction endothelial injury enrolled incidence Inflammatory Kawasaki disease lesion mechanism Mild MIS-C multicenter multisystem inflammatory syndrome in children New Patient patients pediatric Prospective Study SARS-CoV-2 syndrome systemic inflammation Vascular injury Whole blood [DOI] 10.3390/ijms231710106 PMC 바로가기
Identification of bronchoalveolar and blood immune-inflammatory biomarker signature associated with poor 28-day outcome in critically ill COVID-19 patients중환자 COVID-19 환자에서 좋지 않은 28일 결과와 관련된 기관지 폐포 및 혈액 면역 염증 바이오마커 식별Article Published on 2022-06-092022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 바이오마커, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Admission assays BAL BAL fluid BALF Biological biological profile biomarker signature Blood blood concentration bronchoalveolar Bronchoalveolar lavage Characteristics clinical Clinical outcome Concentration coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Critical Critically ill critically ill COVID-19 patients Critically ill patient critically ill patients cytokine defined described eicosanoid Eicosanoids elicited ELISA endothelial injury exhibited fiberoptic bronchoscopy Health Organization identification IFN-γ IL-10 IL-22 IL-5 IL-6 Infection Inflammatory response intensive care intensive care unit interferon Local metabolomic analysis neutrophil outcome Patient performed phenotype respiratory SARS-CoV-2 scale severe acute respiratory syndrome Coronavirus type I interferon Vascular Vasoactive VEGF WHO-CPS World Health Organization [DOI] 10.1038/s41598-022-13179-0 PMC 바로가기 [Article Type] Article
Markers of endothelial cell activation are associated with the severity of pulmonary disease in COVID-19내피 세포 활성화의 마커는 COVID-19에서 폐 질환의 중증도와 관련이 있습니다Article Published on 2022-05-192022-09-11 Journal: PLoS ONE [Category] 바이오마커, [키워드] activate activated Activation acute respiratory distress acute respiratory distress syndrome Antigen association Biomarker Biomarkers biomarkers of inflammation characterized chemokines coronavirus coronavirus disease Coronavirus disease-19 Coronavirus infection correlated COVID-19 cytokine Cytokines D-dimer death endothelial Endothelial cell endothelial cells endothelial injury Factor Hypothesis individual Inflammatory response inflammatory state low-flow oxygen Lung disease mechanical ventilation nasal nasal cannula obstruction oxygen Oxygen requirement Oxygenation participant patients with COVID-19 plasma Plasma levels pro-inflammatory cytokine pro-thrombotic Proinflammatory cytokine proinflammatory cytokines Protein Proteins pulmonary disease released respiratory distress Respiratory distress syndrome selectin severe coronavirus disease severe COVID-19 severity single center Support syndrome tested thrombosis vascular disease vascular inflammation vWF with COVID-19 worsening [DOI] 10.1371/journal.pone.0268296 PMC 바로가기 [Article Type] Article
Long COVID: The Nature of Thrombotic Sequelae Determines the Necessity of Early AnticoagulationReview Published on 2022-04-052023-07-08 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), [키워드] chronic hypoxia early anticoagulation endothelial injury Extracellular vesicles Inflammation Long COVID Phosphatidylserine thrombosis [DOI] 10.3389/fcimb.2022.861703 PMC 바로가기 [Article Type] Review
COVID-19 and thrombosis: The role of hemodynamicsReview article Published on 2022-04-012022-10-05 Journal: Thrombosis research [Category] COVID19(2023년), SARS, 진단, [키워드] addition addressed adverse outcome Affect Brain characterized classical coronavirus disease COVID-19 COVID-19 case Critical crux Cytokine storm diagnostic Disseminated intravascular coagulation dysfunction Effect endothelial injury expressed Factor growth hemodynamic Hemodynamics hypercoagulability hypothese increased risk Injury investigated kidneys Lungs mechanism Microvascular thrombosis neutrophil offer organ pathway Patient Patient care platelet activation responsible sepsis-induced coagulopathy severe COVID-19 Shear stress Stress the disease therapeutic option thromboembolic complication Thromboembolic events Thromboembolism thrombosis thrombotic thrombotic event thrombus formation venous while [DOI] 10.1016/j.thromres.2022.02.016 [Article Type] Review article
Anti-Endothelial Cell Antibodies are not frequently elevated in hospitalized patients with COVID-19항-내피 세포 항체는 COVID-19로 입원한 환자에서 자주 상승하지 않습니다Article Published on 2022-03-142022-09-12 Journal: Acta bio-medica : Atenei Parmensis [Category] MERS, 진단, [키워드] acute respiratory syndrome Admission Antigen autoantibody Coagulopathy conditions Course COVID-19 COVID-19 patient disease severity elevated Endothelial cell endothelial cells endothelial injury evaluate heterogenous hospitalized patient pathogenic Patient patients patients with COVID-19 Stage thrombotic variety with COVID-19 [DOI] 10.23750/abm.v93i1.10799 PMC 바로가기 [Article Type] Article
Inhibitory effects and mechanisms of the anti-covid-19 traditional Chinese prescription, Keguan-1, on acute lung injury급성 폐 손상에 대한 항 코비드 -19 전통 중국 처방, Keguan-1의 억제 효과 및 메커니즘Article Published on 2022-03-012022-08-31 Journal: Journal of ethnopharmacology [Category] MERS, SARS, 비임상, 치료제, [키워드] acute lung injury Adhesion Molecule Administered administration ALI Alpha ameliorated analysed Ang II Angiotensin II ARDS BALF breath cadherin chemokine Chinese claudin Clinical treatment clinical trial collected coronavirus coronavirus disease COVID-19 demonstrated Diseases Effect ELISA Emerging infectious diseases Endothelial cell endothelial injury expression Factor High dose ICAM-1 IL-1β IL-6 IMPROVE incidence Infectious diseases Inflammation Inflammatory Inflammatory factor inflammatory factors inflammatory protein inhibited Injury interleukin intratracheal instillation Keguan-1 keratinocyte lipopolysaccharide low dose LPS lung Lung injury lung tissue lung tissues Macrophage material mechanism medium dose mice Necrosis neutrophil Neutrophils patients with COVID-19 progression proinflammatory protective mechanism Protein provide pulmonary Pulmonary vascular endothelial injury. randomised reduced reducing Registered Seven significantly Support survival rate TCM therapy tight junction TNF-α Traditional Chinese medicine treat Tumour necrosis factor alpha Vascular VE-cadherin was used western blotting [DOI] 10.1016/j.jep.2021.114838 PMC 바로가기 [Article Type] Article