Identification of 1,2,3-triazole-phthalimide derivatives as potential drugs against COVID-19: a virtual screening, docking and molecular dynamic studyCOVID-19에 대한 잠재적 약물로서의 1,2,3-트리아졸-프탈이미드 유도체 식별: 가상 스크리닝, 도킹 및 분자 역학 연구Article Published on 2022-08-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 치료법, [키워드] 123-triazole addition AMES test Analysis Antiviral be positive binding energy calculated complex Compound derivative derivatives docking drug drug candidate drug candidates E35 energy balance exhibited filtered hepatotoxic identification identify in silico inhibitory Interaction investigated M pro MD simulation molecular molecular docking Nucleocapsid proteins other compound other compounds pharmacokinetic phthalimide positive Predictive Prophylaxis protease SARS-CoV-2 SARS-CoV-2 main protease selected target protein target proteins Toxicity toxicity test Treatment triazole Virtual screening [DOI] 10.1080/07391102.2020.1871073 PMC 바로가기 [Article Type] Article
Specific nutrition and metabolic characteristics of critically ill patients with persistent COVID-19Observational Study Published on 2022-07-012022-10-04 Journal: JPEN. Journal of parenteral and enteral nutrition [Category] 임상, [키워드] Admission C-reactive protein Characteristics characteristics of patient characterized cohorts collected constipation coronavirus disease COVID-19 COVID-19 patient Critical Critically ill patient defined demographic data diarrhea energy balance energy deficit Enteral faster gastrointestinal function Hospital stay hypophosphatemia ICU ICU protocol in both group Infection intestinal intubation less Lipid men Mortality mortality rate neuromuscular blockade non-respiratory organ nutrition obese obese patients Patient patients patients with COVID-19 patients without COVID-19 Prone position propofol proportion prospective observational study Protein reduced refeeding syndrome risk Screening Sedation severity scores significantly more SOFA score SOFA scores Specific syndrome target underfeeding. variables with COVID-19 [DOI] 10.1002/jpen.2334 PMC 바로가기 [Article Type] Observational Study
Binge Watching during COVID-19: Associations with Stress and Body WeightCOVID-19 동안의 폭식: 스트레스 및 체중과의 연관성Article Published on 2021-09-282022-09-12 Journal: Nutrients [Category] 진단, [키워드] binge watching BMI Body condition consequence COVID-19 COVID-19 pandemic COVID-related stress cross-sectional eating behavior Effect emotional energy balance Frequency greater highlight increase increase in increasingly individual Intervention investigated lack obesity obesogenic pandemic participant reported Stress triggers Variation weight [DOI] 10.3390/nu13103418 PMC 바로가기 [Article Type] Article
Adhesive rolling of nanoparticles in a lateral flow inspired from diagnostics of COVID-19Research article Published on 2021-04-012022-10-05 Journal: Extreme Mechanics Letters [Category] 진단, [키워드] addition Adhesive Analysis Antigen binding coated with COVID-19 develop diagnostic tests diagnostics energy balance faster Guidance Infectious disease lack lateral flow Lateral flow device LFD Ligand Local Micro-/nano-fluid dynamics mimicking MOST Nanoparticle adhesion parameters receptor Spread triggered Vaccines [DOI] 10.1016/j.eml.2021.101239 [Article Type] Research article
Susceptibility and Severity of Viral Infections in Obesity: Lessons from Influenza to COVID-19. Does Leptin Play a Role?Review Published on 2021-03-202022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] adaptive immune system adipose approach association blunt Cell chronic complications Concentration concerning contribute Control COVID-19 determinant dysregulation Effect Effectiveness energy balance energy metabolism ER stress expressed Factors immune immune response immune system impair impairment Infection Infectious disease Inflammation inflammatory state Influenza influenza epidemic Interaction Leptin leptin resistance lesson mechanism metabolic microenvironment Multiple obesity outcome overcome pandemic Physical inactivity pleiotropic produced receptor reduced Regulatory Research responsible SARS-CoV2 severity Signaling Surveillance susceptibility tissue Vaccine vaccine-induced immune responses viral infection viral infections [DOI] 10.3390/ijms22063183 PMC 바로가기 [Article Type] Review
Metabolic Impacts of Confinement during the COVID-19 Pandemic Due to Modified Diet and Physical Activity HabitsReview Published on 2020-05-262022-10-30 Journal: Nutrients [Category] Coronavirus, MERS, SARS, [키워드] activity acute sedentary lifestyle arising cardiovascular disease Chronic diseases condition consequence Consequences COVID-19 COVID-19 pandemic Deleterious detrimental effect diabetes diet dietary intake energy balance Evidence exacerbate Factor fat habit Health help hypertension identify Impact increase increases in Inflammatory cytokines insulin resistance involved mechanism metabolic metabolic consequence metabolic consequences metabolic disorder metabolic syndrome mitigate physical activity Physical inactivity positive positive energy balance potential risk promoted reduce reduced reducing reduction in risk sarcopenia severe COVID-19 severely ill patient step reduction syndrome total body fat turn while with COVID-19 [DOI] 10.3390/nu12061549 PMC 바로가기 [Article Type] Review