Respiratory SARS-CoV-2 Infection Causes Skeletal Muscle Atrophy and Long-Lasting Energy Metabolism SuppressionArticle Published on 2024-06-282024-09-05 Journal: Biomedicines [Category] update2024, [키워드] COVID-19 energy metabolism Influenza interferons Long COVID Mitochondria Muscle atrophy Muscle fatigue tumor necrosis factor-alpha [DOI] 10.3390/biomedicines12071443 PMC 바로가기 [Article Type] Article
Muscle abnormalities worsen after post-exertional malaise in long COVIDArticle Published on 2024-01-042024-09-05 Journal: Nature Communications [Category] update2024, [키워드] energy metabolism fatigue Fluorescence imaging metabolomics viral infection [DOI] 10.1038/s41467-023-44432-3 PMC 바로가기 [Article Type] Article
Pan-tissue mitochondrial phenotyping reveals lower OXPHOS expression and function across cancer typesarticle Published on 2023-10-052024-09-05 Journal: Burma Med J [Category] update2024, [키워드] Cancer metabolism energy metabolism [DOI] 10.1038/s41598-023-43963-5 PMC 바로가기 [Article Type] article
Divergent metabolic programmes control two populations of MAIT cells that protect the lungarticle Published on 2023-05-252024-09-05 Journal: Nature cell biology [Category] update2024, [키워드] energy metabolism Innate immune cells Mechanisms of disease T cells [DOI] 10.1038/s41556-023-01152-6 PMC 바로가기 [Article Type] article
COVID-19 in Unvaccinated patients with inherited metabolic disorders: A single center experienceResearch article Published on 2022-11-012022-10-05 Journal: European journal of medical genetics [Category] SARS, 유전자 메커니즘, 진단, [키워드] age Care Clinical course Cohort Complication consequence cough COVID-19 COVID-19 infection COVID-19 pandemic cross-sectional death rate Diagnosis diarrhea disease manifestation disorder disorders energy metabolism Fever had no headache Health high risk Hospitalization hyperammonemia hypoglycemia incidence of COVID-19 Infection infections Inherited metabolic disorders intensive care large cohort males management median age metabolic disorder Mild Most patients outcome pandemic Patient patients positive Positive test required Retrospective study SARS-CoV-2 severe complications single center Symptom symptomatic Symptoms tested thrombosis were infected with COVID-19 [DOI] 10.1016/j.ejmg.2022.104602 [Article Type] Research article
SARS-CoV-2 infection and replication kinetics in different human cell types: The role of autophagy, cellular metabolism and ACE2 expressionArticle Published on 2022-11-012022-11-16 Journal: Life sciences [Category] SARS, 유전자 메커니즘, [키워드] A549 ACE2 ACE2 expression angiotensin ATP synthase autophagy BEAS-2B Brain Caco-2 can be used Cell cell line cell lines cellular cellular metabolism COVID-19 COX endothelial energy metabolism evaluated expression level HEK-293 human cell human cell line in vitro intestine intrinsically investigated kidney liver mechanism metabolism Mitochondria mitochondrial metabolism modified cell line molecular mechanism mRNA expression NDUFS2 overexpressed overexpressing overexpression Protein Replication replication kinetics respiratory tract RT-qPCR SARS-COV-2 infection SARS-CoV-2 replication SH-SY5Y susceptibility susceptible cell TMPRSS2 TMPRSS2 expression uninfected cell various tissue viral infection Viral load viral replication were assessed western blot [DOI] 10.1016/j.lfs.2022.120930 PMC 바로가기
Morphological, cellular, and molecular basis of brain infection in COVID-19 patients코로나19 환자 뇌 감염의 형태적, 세포적, 분자적 기초Article Published on 2022-08-302022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alteration anxiety symptoms Astrocyte astrocytes biogenesis Brain brain damage Brain infection brain tissue brains cellular changes in characterized Cohort contribute coronavirus cortical Cortical atrophy COVID-19 COVID-19 infection COVID-19 patient COVID-19 patients death deregulated died dysfunction elicit energy metabolism Evidence exhibited fatigue FIVE foci functional genetic material guide histopathological sign histopathological signs Hypothesis impairment in vitro independent individual infect infected individual Infection Interaction manifestation manifested mechanism metabolism metabolite metabolites mild infection molecular basis neural stem cell Neurological symptoms neuronal neurons Neuropsychiatric Neurotransmitters NRP1 Patient phenotype Protein reduce Replication SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus Severe COVID-19 Infection Spectrum Support Supporting susceptible syndrome tissue sample viability virus [DOI] 10.1073/pnas.2200960119 PMC 바로가기 [Article Type] Article
SARS-CoV-2 infection impairs the insulin/IGF signaling pathway in the lung, liver, adipose tissue, and pancreatic cells via IRF1SARS-CoV-2 감염은 IRF1을 통해 폐, 간, 지방 조직 및 췌장 세포의 인슐린/IGF 신호 전달 경로를 손상시킵니다Article Published on 2022-08-012022-09-11 Journal: Metabolism: clinical and experimental [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] Activation adeno-associated virus adipose Adipose tissue AKT ameliorated analyzed association Autopsy Calu3 Calu3 cell CaLu3 cells Cell cell survival cells condition contribute COVID-19 COVID-19 pathology COVID-19 patient COVID-19 patients COVID-19 severity Critical critical patient critical patients cytokine determine Dexamethasone diabetes Diabetic diabetic patients Dihydrotestosterone Endocrine energy metabolism European population evaluate Evidence exacerbated exhibited Gain Gene Expression Genes GFP HEK293T Hospitalized Host human ACE2 human cells hyperglycemia impair impairment infected with SARS-CoV-2 insulin insulin resistance Insulin signaling Insulin/IGF signaling pathway interferon regulatory factor Interferone intron IRF1 liver lung Lungs male Male sex MAPK metabolic metabolic abnormalities Metabolic abnormality metabolism mouse model mTOR Multiorgan dysfunction Multiple organ damage Non-COVID-19 Non-COVID-19 patients obese obesity Older Older age Organoid overexpressing pancreatic Pancreatic cell pancreatic islets pathology patients patients with COVID-19 PI3K potential mechanism Prevalence provide Regulation reported Repository risk factor Risk factors SARS-CoV-2 SARS-CoV-2 infected cell SARS-CoV-2 infected cells SARS-COV-2 infection serotype severe COVID-19 severity Signaling signaling pathway significantly stem cell survival tissue tissue damage Tissue damage. tissues Transcriptome transcriptome dataset transcriptome datasets Transgenic mouse variant Whole blood whole blood transcriptome with COVID-19 [DOI] 10.1016/j.metabol.2022.155236 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Achieves Immune Escape by Destroying Mitochondrial Quality: Comprehensive Analysis of the Cellular Landscapes of Lung and Blood Specimens From Patients With COVID-19SARS-CoV-2, 미토콘드리아 품질을 파괴하여 면역 탈출 달성: COVID-19 환자의 폐 및 혈액 표본의 세포 환경에 대한 종합 분석Article Published on 2022-07-012022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료제, [키워드] activated activating alveolar alveolar epithelial cell alveolar epithelial cells alveolar macrophage Alveolar macrophages analyzed antiviral immunity B cell B cells blocked Blood calcium cell count Comprehensive coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients crossfire cytokine Cytokine storm dataset Defense Degradation energy metabolism epithelial epithelial cell epithelial cells escape exacerbated excessive inflammation explain expression Gene Expression HIF1a Host IFI27 immune immune cells Immune escape Inflammation inhibited Interaction interferon landscape lung tissue Lungs Macrophage macrophages manifestation MCU metabolic pathway metabolism Mitochondria mitochondrial mitochondrial fission mitochondrial functions mitochondrial quality. pathway patients with COVID-19 Perspective plasma pro-inflammatory Regulatory T cell regulatory T cells released Replication respiratory capacity resulting RNA-sequencing SARS-CoV-2 significant changes in Single-cell RNA-sequencing T cells target transformation Tregs type I viral infection [DOI] 10.3389/fimmu.2022.946731 PMC 바로가기 [Article Type] Article
A diabetic milieu increases ACE2 expression and cellular susceptibility to SARS-CoV-2 infections in human kidney organoids and patient cells당뇨병 환경은 인간 신장 오르가노이드 및 환자 세포에서 SARS-CoV-2 감염에 대한 ACE2 발현 및 세포 감수성을 증가시킵니다Article Published on 2022-06-072022-09-11 Journal: Cell Metabolism [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] ACE2 ACE2 expression aerobic aerobic glycolysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 biopsy Cell cells cellular condition COVID-19 COVID-19 pathogenesis Critical develop diabete diabetes diabetes 2 Diabetic diabetic kidney diabetic patient diabetic patients dichloroacetate door energy metabolism enzyme exhibited Glycolysis hallmark human kidney human kidney organoids. increase individual inhibitor Intervention kidney Kidney disease kidney organoid kidney organoids metabolism mitochondrial Organoid organoids Patient prevented programming reduced resulting SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections severe COVID-19 susceptibility Viral detection Viral load [DOI] 10.1016/j.cmet.2022.04.009 PMC 바로가기 [Article Type] Article