Global Regulatory and Public Health Initiatives to Advance Pediatric Drug Development for Rare DiseasesArticle Published on 2022-11-012022-11-16 Journal: Therapeutic innovation & regulatory science [Category] 신약개발, [키워드] advance affected approach children clinical trials COVID-19 COVID-19 pandemic development disease drug ecosystem Efficacy effort engage equity facilitate Follow-up include initiative key factor lack outcome measure Patient pediatric pediatric drug development promote Public public health rare disease rare diseases Regulatory Regulatory policy. Study design Therapies Trial trials [DOI] 10.1007/s43441-022-00409-w PMC 바로가기
Old drugs, new tricks: leveraging known compounds to disrupt coronavirus-induced cytokine stormArticle Published on 2022-10-102022-11-16 Journal: NPJ Systems Biology and Applications [Category] COVID19(2023년), SARS, 신약개발, [키워드] acute respiratory distress agonists Antimicrobials approach approved drugs automated biological pathway candidate drug Combination competing complex Compound compounds COVID-19 infection Cytokine storm Dexamethasone disrupt downstream interaction driving drug drug combination Drug discovery drugs drugs targeting dysregulation Effects element engage functional Host host immune system identify immune in silico Approach Interaction Intervention less mTOR inhibitor other disease peer-reviewed predicted Regulatory scored signaling cascade significantly subset suppressor syndrome target while [DOI] 10.1038/s41540-022-00250-9 PMC 바로가기
Too Healthy to Fall Sick? Longevity Expectations and Protective Health Behaviours during the First Wave of COVID-19Research article Published on 2022-10-012022-10-05 Journal: Journal of Economic Behavior & Organization [Category] 유전자 메커니즘, [키워드] age Ageing assessment Care Characteristics conditions COVID-19 death decrease engage estimate Europe exhibiting expectation expected forgone medical treatment Gender Health Health behaviours health capital Health status healthy Hypothesis increase increase in individual level individuals information instrumental variables less Longevity longevity expectations pandemic parental private information Probability Protective Protective behaviours retirement risk share sick social distancing Standard deviation survey Treatment Wave [DOI] 10.1016/j.jebo.2022.08.015 [Article Type] Research article
An ACE2-dependent Sarbecovirus in Russian bats is resistant to SARS-CoV-2 vaccinesArticle Published on 2022-09-222022-11-15 Journal: PLoS Pathogens [Category] SARS, 진단, [키워드] acute respiratory syndrome Asia bat bats Cell cell entry circulating COVID-19 pandemic Cross reactivity engage facilitate Health host cell Human human ACE2 human cells human pathogen identify individual infect Invasion Lineage majority monoclonal antibody outbreak pseudotype RBD receptor Receptor binding domain sarbecovirus SARS-CoV SARS-CoV-1 and -2 SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 vaccine serological serum tested the RBD Vaccine virus virus while [DOI] 10.1371/journal.ppat.1010828 PMC 바로가기
Photochemical Identification of Auxiliary Severe Acute Respiratory Syndrome Coronavirus 2 Host Entry Factors Using μMapArticle Published on 2022-09-142022-11-16 Journal: Journal of the American Chemical Society [Category] SARS, 변종, [키워드] ACE2 ACE2 expression acute respiratory syndrome auxiliary cell entry complex coronavirus coronavirus 2 COVID-19 pandemic Critical Delta eight engage ENhance enzyme expression facilitate Factor Genetic Host human cell identification identify identifying labeling lymphocyte membrane fusion pathophysiology platform powerful tool Protein receptor receptors respiratory SARS-CoV-2 significantly spike variant systemically the spike protein tissues transmembrane serine protease viral entry Wuhan [DOI] 10.1021/jacs.2c06806 PMC 바로가기
OnTrack Chile for people with early psychosis: a study protocol for a Hybrid Type 1 trialArticle Published on 2022-09-052022-10-05 Journal: Trials [Category] 임상, [키워드] adaptation Administered age approach approaches assessment Care Chilean clinics conducted Controlled trial Coordinated specialty care country Course COVID-19 pandemic determine dynamic Early psychosis Effectiveness engage Enrollment episode evaluate expected facilitator feasibility finding Global mental health group help hybrid Hybrid Type 1 trial implementation include individual Intervention Latin Latin America lesson Mental mental health National offered outcome over participant Participants primary care Process protocol provided Psychosis public health RCT Research secondary Specialized coordinated services for first episode psychosis. Study protocol Support Symptom Symptoms Treatment Trial Type unique USA [DOI] 10.1186/s13063-022-06661-7 PMC 바로가기 [Article Type] Article
Identification of a cross-neutralizing antibody that targets the receptor binding site of H1N1 and H5N1 influenza virusesArticle Published on 2022-09-022022-10-06 Journal: Nature Communications [Category] Fulltext, 신종인플루엔자, 진단, [키워드] analyses antibody antiviral drug benefit chimeric conserved cross-neutralization cross-neutralizing cross-protection eight engage epitope overlapping Evidence H1N1 H5N1 identification in vivo Influenza influenza vaccines influenza virus mAb molecular monoclonal antibody neutralization Neutralizing activity offer pandemic receptor binding site residue Surface glycoprotein target Tolerance Vaccine viral challenge virus virus entry viruses [DOI] 10.1038/s41467-022-32926-5 PMC 바로가기 [Article Type] Article
Contributions of the N-terminal intrinsically disordered region of the severe acute respiratory syndrome coronavirus 2 nucleocapsid protein to RNA-induced phase separationArticle Published on 2022-09-012022-11-16 Journal: Protein Science : A Publication of the Protein Soc [Category] SARS, 변종, [키워드] activity acute respiratory syndrome addition affected change coronavirus COVID-19 infections decrease droplet engage Genome genomic RNA host infection induce intrinsically liquid-liquid phase separation modulating molecular Mutation N-terminal N-terminus NMR nucleocapsid protein nucleocapsid protein. omicron phosphorylated post-translational modification Protein Replication RNA RNA concentration SARS-CoV-2 Structural properties the SARS-CoV-2 Transcription undergo variant viral replication virions [DOI] 10.1002/pro.4409 PMC 바로가기
Physical activity and academic achievement: an analysis of potential student- and school-level moderatorsArticle Published on 2022-08-302022-10-05 Journal: The international journal of behavioral nutrition and physical activity [Category] 임상, [키워드] Academic achievement Accelerometers Affect age Analysis analysis baseline Characteristics children collected Course cross-sectional Effect Elementary students engage examined Factor Follow-up Gender GRADE grade 3 Grade 5 Grades Hispanic ethnicity Inconclusive indicated investigated moderate NIH outcomes physical activity proportion recruited Registered Research School Schools socioeconomic status Socioeconomic status. statistically significant student unique while [DOI] 10.1186/s12966-022-01348-3 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Delta variant induces enhanced pathology and inflammatory responses in K18-hACE2 miceArticle Published on 2022-08-292022-11-15 Journal: PLoS ONE [Category] SARS, 변종, 치료제, [키워드] activated Analysis Beta Brain Cell challenge COVID-19 COVID-19 pandemic Delta delta variant Delta VOC Differential gene expression disease dose engage ENhance evaluate experiment Gene Expression highest histopathological host response IFN-γ in silico in vivo induce infiltration Inflammation Inflammatory response interferon response K18-hACE2 mice lung lung tissue magnitude mice nasal no significant difference observation Pathogenesis pathology Pneumonia pro-inflammatory cytokine qRT-PCR analysis Receptor binding RNA-sequencing SARS-CoV-2 strain Strains suggested T-cell TCR Total Transmissibility unique Vaccines variants of concern Viral RNA VoC was performed [DOI] 10.1371/journal.pone.0273430 PMC 바로가기