Enhancing the Immunogenicity of RBD Protein Variants through Amino Acid E484 Mutation in SARS-CoV-2Article Published on 2022-09-132022-11-15 Journal: Viruses [Category] SARS, 변종, 진단, 치료기술, [키워드] acid Antibody detection Antibody testing antigenic COVID-19 COVID-19 pandemic Critical E. coli E484K effective Effectiveness Enhancing Escherichia coli Evolution of SARS-CoV-2 expressed expression immunogenicity in vitro mice mutant mutants Neutralizing antibodies nine Protein raise RBD RBD protein recombinant RBD protein SARS-CoV-2 SARS-CoV-2 RBD protein single-point mutants the RBD protein vaccination Vaccine Vaccines variants western blotting wild type [DOI] 10.3390/v14092020 PMC 바로가기
Enhancing COVID Rehabilitation with Technology (ECORT): protocol for an open-label, single-site randomized controlled trial evaluating the effectiveness of electronic case management for individuals with persistent COVID-19 symptomsArticle Published on 2022-09-022022-10-04 Journal: Trials [Category] SARS, 임상, 치료제, [키워드] acute infection addition asked assessment Blended care breathlessness Care chronic condition Cognitive impairment Complete connection Course COVID COVID patient COVID-19 decrease determine disability ECM Effectiveness Electronic case management Enhancing evaluate Evidence fatigue Follow-up group Health help implementation IMPROVE individual Infection Intervention Long Long COVID majority management measure mental health morbidity National Open-label outcome outcomes participant persistent COVID-19 symptom platform Post-COVID rehabilitation. Prevalence Primary outcome protocol Randomized Randomized controlled trial receive rehabilitation resources Result SARS-CoV-2 scale severity Shortness of breath subset suggested Symptom Symptoms technology the WHO total score Treatment treatment guideline Trial usual care while [DOI] 10.1186/s13063-022-06578-1 PMC 바로가기 [Article Type] Article
The COVID-19 pandemic and problematic usage of the internet: Findings from a diverse adult sample in South AfricaResearch article Published on 2022-09-012022-10-05 Journal: Journal of psychiatric research [Category] 변종, [키워드] adaptive age analyses Analysis ANOVA association change clinical variable compulsive coping strategies coronavirus disease coronavirus disease 19COVID-19 COVID-19 COVID-19 pandemic COVID-19 related stress cross-sectional survey cumulative effect sizes Effects Enhancing explained female finding hypothesised implementation indicated lockdown medium other variable partial least square participant populations problematic usage of the internetPUI problems PUI reduce Regression relationship Resilience Result risk SA significantly South Africa South AfricaSA Stress suggested Symptom traits variables was used [DOI] 10.1016/j.jpsychires.2022.06.035 [Article Type] Research article
SARS-CoV-2 potential drugs, drug targets, and biomarkers: a viral-host interaction network-based analysisSARS-CoV-2 잠재적 약물, 약물 표적 및 바이오마커: 바이러스-숙주 상호작용 네트워크 기반 분석Article Published on 2022-07-132022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 바이오마커, 변종, 신약개발, 임상, 치료제, [키워드] Amiodarone Analysis anthracyclines Antibiotics Antiviral antiviral agent Biomarker Blood CDK1 cell cycle CENPF CIT Complete COVID-19 cytarabine daily living diagnostic biomarker Diagnostic biomarkers Differentially expressed genes digitoxin Doxorubicin drug drug target drugs Enhancing enrichment ERG example expression FDA-approved drug FDA-approved drugs FLUOROURACIL gemcitabine global pandemic HMOX1 host cell hydroxyurea identify Infection inhibitors Interaction less mir-93 mitotic MYB omicron Omicron variant pathway Pathways performed Probability prognostic biomarker repositioning retrieved RRM2 SARS-CoV-2 sotalol suggested targets the disease therapeutic TOP2A transcriptomic transmission rate Treatment variant variants viral-host interaction virus [DOI] 10.1038/s41598-022-15898-w PMC 바로가기 [Article Type] Article
Enhancing untargeted metabolomics using metadata-based source annotation Research Published on 2022-07-072022-10-05 Journal: Nature biotechnology [Category] 진단, [키워드] Analysis Applying approach Enhancing Human increase metabolomics molecular features Tandem mass spectrometry [DOI] 10.1038/s41587-022-01368-1 [Article Type] Research
Enhancing COVID-19 Epidemic Forecasting Accuracy by Combining Real-time and Historical Data From Multiple Internet-Based Sources: Analysis of Social Media Data, Online News Articles, and Search Queries여러 인터넷 기반 소스의 실시간 및 과거 데이터를 결합하여 COVID-19 전염병 예측 정확도 향상: 소셜 미디어 데이터, 온라인 뉴스 기사 및 검색어 분석Article Published on 2022-06-162022-09-11 Journal: JMIR Public Health and Surveillance [Category] COVID19(2023년), SARS, 변종, [키워드] Accuracy agency Analysis approach articles autoregression model Baidu baseline China Combination confirmed COVID-19 case COVID COVID 19 COVID-19 COVID-19 epidemic COVID-19 outbreak disease Disease surveillance ENhance Enhancing Epidemic epidemic forecasting Epidemics First wave Forecasting greater help highest IMPROVE Infectious disease infectious disease epidemiology Intervention Measures Multiple New online news Outbreaks Pearson correlation predictive power public health resource SARS-CoV-2 SARS-CoV-2 virus search query shown significantly social medial. statistically significant Surveillance tested variant variants virus [DOI] 10.2196/35266 PMC 바로가기 [Article Type] Article
The Efficacy of a Brief, Altruism-Eliciting Video Intervention in Enhancing COVID-19 Vaccination Intentions Among a Population-Based Sample of Younger Adults: Randomized Controlled TrialRandomized Controlled Trial Published on 2022-05-302022-10-04 Journal: JMIR Public Health and Surveillance [Category] COVID19(2023년), SARS, 임상, [키워드] 1:1 Administered adoption Adults age altruism applied assigned booster Canadian change changes in chi-square test Controlled COVID-19 COVID-19 vaccination COVID-19 vaccine deaths demonstrated Digital health digital intervention Diseases Efficacy Enhancing evaluate Health health information health intervention Health promotion Hospitalization Intention Intervention Measures media Model not significant Older online health pandemic participant Pearson performed postintervention Precaution Process prosocial motives provide public health public health authority Randomized Randomized controlled trial RCT receive receiving recommendation recruited reducing Research Sample the vaccine thought Trial vaccinate vaccinated against COVID-19 vaccination Vaccine Vaccine hesitancy vaccine intention vaccine intentions video intervention virus was performed web survey were assessed younger adults Youth [DOI] 10.2196/37328 PMC 바로가기 [Article Type] Randomized Controlled Trial
How Do Point Mutations Enhancing the Basic Character of the RBDs of SARS-CoV-2 Variants Affect Their Transmissibility and Infectivity Capacities?SARS-CoV-2 변종 RBD의 기본 특성을 향상시키는 점 돌연변이가 전염성과 감염력에 어떤 영향을 미칩니까?Review Published on 2022-04-102022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 receptor ACE2 receptors arginine arginine residue arginine residues basic binding affinity cell receptors character charged residues contribute coronavirus coulombic charges COVID-19 creating delta variant difference Effect electrostatic Enhancing glutamic acid host cells increase in Infectivity lysine Mu variant mutations Omicron variant Point Point mutation point mutations RBD RBD-ACE2 Recognition residue Salt Bridge SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Spike protein spike protein RBD Spike proteins Spread spreading capacity surface electrostatic potential the RBD the SARS-CoV-2 the spike protein Transmissibility variants [DOI] 10.3390/v14040783 PMC 바로가기 [Article Type] Review
Enhancing Physical Activity and Psychological Well-Being in College Students during COVID-19 through WeActive and WeMindful InterventionsRandomized Controlled Trial Published on 2022-03-312022-10-04 Journal: International Journal of Environmental Research an [Category] 임상, [키워드] activity aerobic All participant assigned college COVID-19 Effect effective eight Enhancing Follow-up group intensity Intervention moderate participant physical physical activity Qualtrics Randomly Resilience resilience score Resistance training scale significant interaction significantly increased student university students web-based intervention. [DOI] 10.3390/ijerph19074144 PMC 바로가기 [Article Type] Randomized Controlled Trial
Four Weeks Treatment with Glecaprevir/Pibrentasvir + Ribavirin-A Randomized Controlled Clinical Trial글레카프레비르/피브렌타스비르 + 리바비린-A 무작위 대조 임상 시험으로 4주간 치료Randomized Controlled Trial Published on 2022-03-162022-09-11 Journal: Viruses [Category] 임상, 치료제, [키워드] analyzed baseline chronic hepatitis chronic hepatitis C clinical Controlled Controlled trial Course COVID-19 pandemic cure DAA eight Enhancing fibrosis Genotype glecaprevir HCV Health Organization Hepatitis hepatitis C intention to treat Liver fibrosis multicenter naïve open label Patient patients treated pibrentasvir predictor predictors Randomized Randomized controlled trial reducing ribavirin stratified sustained Treatment Trial Viral load virological response Week World Health Organization [DOI] 10.3390/v14030614 PMC 바로가기 [Article Type] Randomized Controlled Trial