Analysis of transcriptomics data from COVID-19 patients: a pilot researchShort Communication Published on 2024-01-192024-09-05 Journal: Folia Microbiologica [Category] update2024, [키워드] COVID-19 Differentially expressed genes enriched pathways Gene enrichment analysis RNA-Seq SARS-CoV-2 transcriptomics [DOI] 10.1007/s12223-024-01130-x PMC 바로가기 [Article Type] Short Communication
Combining metabolome and clinical indicators with machine learning provides some promising diagnostic markers to precisely detect smear-positive/negative pulmonary tuberculosis대사체와 임상 지표를 기계 학습과 결합하면 도말 양성/음성 폐결핵을 정확하게 감지하는 몇 가지 유망한 진단 마커를 제공합니다.Article Published on 2022-08-252022-09-11 Journal: BMC Infectious Diseases [Category] Coronavirus, 바이오마커, 치료기술, [키워드] Amino acid Analysis best Biomarker Biomarkers cause Characteristics Combination conducted Control controls COVID-19 death death case death cases detect Diagnosis diagnostic diagnostic biomarker Diagnostic biomarkers discriminant analysis dysfunction enriched pathways fatty Fatty acid feature global pandemic high accuracy Infectious disease machine machine learning marker metabolisms metabolite metabolome metabolomic metabolomic analysis metabolomic profiling metabolomics Mycobacterium tuberculosis Mycobacterium tuberculosis (Mtb) offer Patient patients performed plasma Precision provide pulmonary tuberculosis R package random Random forest Seven significant enrichment smear Smear-positive/negative pulmonary tuberculosis Support SVM TB patient three group three groups Tuberculosis Tuberculosis (TB) was performed [DOI] 10.1186/s12879-022-07694-8 PMC 바로가기 [Article Type] Article
Multi-staged gene expression profiling reveals potential genes and the critical pathways in kidney cancer Research Published on 2022-05-042022-10-05 Journal: Scientific Reports [Category] 바이오마커, [키워드] appear applied approach ARHGAP26 Cancer Cell CHAF1A CNPPD1 collected complex complex disease Critical database dataset death diabete diagnostic differentially expressed gene Differentially expressed genes disease disease onset DLC1 enriched pathways event FDX1 gene expression dataset Gene expression profiling information Interaction ITGBL1 kidney Kidney diseases LAMP2 MAP3K13 MAPK molecular MTO1 NSMAF pathophysiology pathway phenotype PPP2R5E progression PRSS23 receptor renal Research reveal SCARB2 Stage STAMBP survival SYNJ1 tight junction TPGS2 YY1 [DOI] 10.1038/s41598-022-11143-6 [Article Type] Research
Innate immune response analysis in COVID-19 and kawasaki disease reveals MIS-C predictorsCOVID-19 및 가와사키병의 타고난 면역 반응 분석은 MIS-C 예측 인자를 밝힙니다Article Published on 2022-03-012022-09-11 Journal: Journal of the Formosan Medical Association = Taiw [Category] SARS, 변종, 치료기술, [키워드] acute SARS-CoV-2 infection Adults analyses Analysis ArrayExpress association Blood blood cell Blood cells CASP1 CD14 CD36 children Cohort correlated COVID-19 COVID-19 diagnosis COVID-19 severity dataset determine disease downloaded dysregulated dysregulation enriched pathway enriched pathways expression level FCGR2A gene expression signature genetic polymorphisms HLA-DOB IFI16 IFNAR1 immune dysregulation immune response immune responses increased expression Inflammatory Innate innate immune innate immune gene innate immune genes innate immune response Innate immunity Interaction interactions irak4 IRF3 Kawasaki disease MIS-C moderate Multisystem inflammatory syndrome network network analysis NLRP3 pathway Patient PELI1 polymorphism predict predictor predisposition Pycard reveal SARS-CoV-2 infections severe COVID-19 severity STAT3 STING susceptibility syndrome TLR2 TLR7 TLR8 Transcriptome transcriptome datasets transcriptomes variant variants was used with COVID-19 [DOI] 10.1016/j.jfma.2021.06.009 PMC 바로가기 [Article Type] Article
Effects of poor sleep on the immune cell landscape as assessed by single-cell analysisArticle Published on 2021-11-252022-10-04 Journal: Communications Biology [Category] 바이오마커, [키워드] Affect Analysis analyzed Autoimmunity B cells blood sample CD4 Cell cells cellular and molecular cellular senescence Cytometry Diseases distribution Effect enriched pathways Frequency gene signatures healthy immune Immune cell increased risk Infection Inflammation interactions intercellular marker mechanism participant pathologic condition pathway plasma Poor predisposition public health reduced Regulatory Risk factors single-cell Single-cell RNA sequencing subset transcriptional upregulated [DOI] 10.1038/s42003-021-02859-8 PMC 바로가기 [Article Type] Article
Decrypting the role of predicted SARS-CoV-2 miRNAs in COVID-19 pathogenesis: A bioinformatics approachCOVID-19 발병 기전에서 예측된 SARS-CoV-2 miRNA의 역할 해독: 생물정보학 접근Article Published on 2021-09-012022-09-11 Journal: Computers in biology and medicine [Category] SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Analysis Apoptosis apoptotic pathway apoptotic pathways approach bioinformatics computational tool computational tools Coronavirus-2 COVID-19 COVID-19 pathogenesis dataset deregulated down-regulated down-regulated gene e genes enriched pathways function functional enrichment Genes global pandemic Host immune immune responses immune system infected cells infections influence immune responses involved KEGG pathway analysis microRNA miRNA miRNAs modulating molecular mechanism p53 Pathogenesis pathogenicity pathway predicted progression provide regulated Repository SARS-CoV-2 SARS-CoV-2 infected cell SARS-CoV-2 infected cells SARS-CoV-2 miRNA SARS-CoV2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Signaling significantly survival target the SARS-CoV-2 transcriptomic profile up-regulated viral miRNA viral miRNAs viral pathogenesis virus [DOI] 10.1016/j.compbiomed.2021.104669 PMC 바로가기 [Article Type] Article
Quantitative proteomics of hamster lung tissues infected with SARS-CoV-2 reveal host factors having implication in the disease pathogenesis and severitySARS-CoV-2에 감염된 햄스터 폐 조직의 정량적 단백질체학은 질병 발병기전 및 중증도에 영향을 미치는 숙주 인자를 나타냅니다Article Published on 2021-07-012022-09-11 Journal: FASEB journal : official publication of the Federa [Category] SARS, 유전자 메커니즘, [키워드] acute infection acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition alveolar damage Analysis carried clinical parameter Clinical parameters coagulation cascade complement convalescence coronavirus COVID-19 COVID-19 patient COVID-19 patients DAD differential expression differentially expressed differentially expressed proteins Diffuse alveolar damage effort enriched pathways evaluate expression Factor Ferroptosis groups hamster hamsters histopathological Host in vivo infected with SARS-CoV-2 involved isolates Local lung Lung function Lung pathology lung proteome lung tissue lung tissues mass spectrometry Mesocricetus Orbitrap Pathogenesis pathological change pathophysiological Pathway analysis platelet activation Post-infection progression protective role Protein proteomic proteomics Pulmonary Surfactant Quantitative reported resolved SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis SARS-CoV-2-infected hamster SARS-CoV-2-infected hamsters severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severity SFTPB SFTPD significantly surfactant Syrian golden hamster Syrian Golden hamsters the disease tissue sample tissue samples [DOI] 10.1096/fj.202100431R PMC 바로가기 [Article Type] Article
Human coronaviruses in idiopathic Parkinson’s disease: Implications of SARS-CoV-2’s modulation of the host’s transcriptome특발성 파킨슨병의 인간 코로나바이러스: SARS-CoV-2의 숙주 전사체 조절의 의미Article Published on 2021-04-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] SARS, 유전자 메커니즘, 치료기술, [키워드] among others analyses Analysis comparison Control coronavirus determine disease Diseases Effect enriched pathways enrichment analyses enrichment analysis false discovery rate FDR Gene Expression Gene ontology Gene Set Enrichment Analyses GSEA head Head-to-head comparisons Host Human human coronavirus human coronaviruses Huntington's disease immune response indicated modulation mononuclear cell motor nucleus mRNA NAFLD neurodegeneration neurodegenerative Neuroinvasive nigra not limited Ontology overlap overlapping parasitism parkinson s disease Parkinson's Disease Pathogenesis pathway Patient PBMC performed Peripheral blood Perturbation retrieved SARS-CoV-2 SARS-COV-2 infection scrutiny statistically significant substantia substantia nigra Surveillance tissue tissues Transcriptome transcriptomic Whole blood [DOI] 10.1016/j.meegid.2021.104733 PMC 바로가기 [Article Type] Article
Investigation of COVID-19 comorbidities reveals genes and pathways coincident with the SARS-CoV-2 viral diseaseCOVID-19 동반 질환 조사에서 SARS-CoV-2 바이러스 질환과 일치하는 유전자 및 경로 밝혀Article Published on 2020-11-302022-09-10 Journal: Scientific Reports [Category] SARS, 유전자 메커니즘, [키워드] allele alleles Analysis Bioinformatics analysis Comorbidities Comorbidity condition conducted conjunction COVID-19 COVID-19 pandemic COVID-19 severity Data integration dataset datasets diabetes enriched pathway enriched pathways evaluated human disease hypertension immune system information initiated investigation knowledge Lung diseases mechanism mouse model Mouse models Ontology pathway Pathway analysis Pathways performed phenotype Phenotypes Phenotypic analysis Predictive medicine Reactome Research reveal SARS-COV-2 infection SARS-CoV-2 virus significant enrichment subsequent the SARS-CoV-2 the SARS-CoV-2 virus viral disease virus [DOI] 10.1038/s41598-020-77632-8 PMC 바로가기 [Article Type] Article
The Roles of Bursal Nonapeptide (BP9) on AIV Vaccine Immune Response in Chick Immunization and on Avian Immature B CellArticle Published on 2019-01-012023-06-21 Journal: Protein and peptide letters [Category] 조류인플루엔자, [키워드] AIV inactivated vaccine Antibody Response Bursal nonapeptide (BP9) DT40 cells enriched pathways functionalbiological processes.. [DOI] 10.2174/0929866526666190730101455