Research Progress on Spike-Dependent SARS-CoV-2 Fusion Inhibitors and Small Molecules Targeting the S2 Subunit of SpikeReview Published on 2024-04-302024-09-05 Journal: Viruses [Category] update2024, [키워드] Arbidol Entry inhibitor fusion inhibitor molecular docking S2 segment S2 subunit SARS-CoV-2 Spike dependent surface plasmon resonance toremifene [DOI] 10.3390/v16050712 PMC 바로가기 [Article Type] Review
Natural products as a source of Coronavirus entry inhibitorsCellular and Infection Microbiology Review Published on 2024-02-212024-09-05 Journal: Frontiers in Cellular and Infection Microbiology [Category] update2024, [키워드] Antiviral coronavirus COVID-19 Entry inhibitor fusion inhibitor natural product SARS-CoV-2 [DOI] 10.3389/fcimb.2024.1353971 PMC 바로가기 [Article Type] Cellular and Infection Microbiology Review
An engineered recombinant protein containing three structural domains in SARS-CoV-2 S2 protein has potential to act as a pan-human coronavirus entry inhibitor or vaccine antigenCoronaviruses Published on 2023-08-112024-09-05 Journal: Emerging Microbes & Infections [Category] update2024, [키워드] coronavirus Entry inhibitor pan-human coronavirus stem helix Vaccine [DOI] 10.1080/22221751.2023.2244084 PMC 바로가기 [Article Type] Coronaviruses
Comparison of SARS-CoV-2 entry inhibitors based on ACE2 receptor or engineered Spike-binding peptidesVaccines and Antiviral Agents Published on 2023-08-092024-09-05 Journal: Journal of virology [Category] update2024, [키워드] ACE2 Entry inhibitor SARS-CoV-2 spike [DOI] 10.1128/jvi.00684-23 PMC 바로가기 [Article Type] Vaccines and Antiviral Agents
Cellular electrical impedance to profile SARS-CoV-2 fusion inhibitors and to assess the fusogenic potential of spike mutantsArticle Published on 2023-03-262024-09-05 Journal: Antiviral Research [Category] update2024, [키워드] cell-cell fusion Cellular electrical impedance Entry inhibitor SARS-CoV-2 spike [DOI] 10.1016/j.antiviral.2023.105587 PMC 바로가기 [Article Type] Article
Teicoplanin derivatives block spike protein mediated viral entry as pan-SARS-CoV-2 inhibitorsArticle Published on 2023-01-032024-09-05 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] update2024, [키워드] angiotensin converting enzyme 2 Entry inhibitor SARS-CoV-2 Spike protein Teicoplanin [DOI] 10.1016/j.biopha.2023.114213 PMC 바로가기 [Article Type] Article
Sertraline Is an Effective SARS-CoV-2 Entry Inhibitor Targeting the Spike ProteinArticle Published on 2022-12-212023-07-11 Journal: Journal of Virology [Category] COVID19(2023년), [키워드] Entry inhibitor Inflammation SARS-CoV-2 sertraline spike [DOI] 10.1128/jvi.01245-22 PMC 바로가기
State-of-the-art and emerging antivirals for chronic hepatitis B infectionReview Published on 2022-12-012023-06-13 Journal: Expert opinion on pharmacotherapy [Category] B형 간염, [키워드] Antisense oligonucleotide capsid assembly modulator cccDNA Entry inhibitor functional cure nucleic acid polymer nucleoside nucleotide Small interfering RNA [DOI] 10.1080/14656566.2022.2144219 [Article Type] Review
Broad Tricyclic Ring Inhibitors Block SARS-CoV-2 Spike Function Required for Viral EntryArticle Published on 2022-10-142022-11-16 Journal: ACS Infectious Diseases [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 acute respiratory syndrome affected angiotensin-converting enzyme 2 binding binding pocket block blocked broad inhibitor candidate cell-cell fusion cellular circulating SARS-CoV-2 variant Compound conformational change conserved coronavirus Critical Entry inhibitor entry inhibitors entry pathway facilitate function glycoprotein host cell Infection inhibitory effect interfere mode of action plasma membrane receptor Receptor binding domain required Ring SARS-CoV SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 spike selective significantly Small molecules spike subsequent tested the SARS-CoV-2 these compound Tricyclic Trigger viral entry viral spike [DOI] 10.1021/acsinfecdis.1c00658 PMC 바로가기
Systematic virtual screening in search of SARS CoV-2 inhibitors against spike glycoprotein: pharmacophore screening, molecular docking, ADMET analysis and MD simulationsArticle Published on 2022-10-012022-11-15 Journal: Molecular diversity [Category] COVID19(2023년), SARS, 치료제, [키워드] absence acting acute respiratory syndrome Amino acid Analysis Anti-viral binding site catalytic coronavirus disease Coronavirus-2 COVID-19 distribution docking score effective Entry inhibitor glycoprotein host cell in silico inhibitor Interaction less Ligand MD simulation MD simulations medications metabolism molecular molecular docking nucleic acid offered performed Precision research finding residue SARS CoV-2 spike spike glycoprotein stability starting point target Toxicity viral entry Virtual screening [DOI] 10.1007/s11030-022-10394-9 PMC 바로가기