Active components in Ephedra sinica stapf disrupt the interaction between ACE2 and SARS-CoV-2 RBD: Potent COVID-19 therapeutic agents
Ephedra Sinica STAPF의 활성 성분은 ACE2와 SARS-COV-2 RBD 사이의 상호 작용을 방해합니다 : 강력한 COVID-19 치료제
Article
[키워드] 293T-ACE2
4-hydroxy-6-methoxyquinoline-2-carboxylic acid (PubChem CID: 22017520)
4-hydroxyquinoline-2-carboxylic acid (PubChem CID: 3845)
4,6-dihydroxyquinoline-2-carboxylic acid (PubChem CID: 440752)
ACE2
ACE2-RBD
activity
alleviate
angiotensin
Angiotensin-converting enzyme
angiotensin-converting enzyme 2
Asia
Asthma
binding domain
Calu
calu-3 cells
carboxylic acid
carried
cells
Chinese
Cold
component
Compound
compounds
cough
COVID-19
COVID-19 therapeutic agent
Deterioration
disrupt
disrupting
docking
domain
effort
ephedra
Ephedra sinica
Ethanol
HPLC
hydrogen
Hydrogen bond
hydroxy
indicated
inhibit
inhibit SARS-CoV-2
inhibiting
Inhibition assays
inhibitory activity
Interaction
Isolation
knock-out
Lung diseases
material
mechanism
molecular docking
NMR
observé
potent
potential therapeutic agent
potential therapeutic agents
PPI
PPI inhibitor
Prevent
protein-protein interaction
provided
pseudoviruses
PubChem
quinoline
Quinoline-2-carboxylic acid
S protein
SARS-CoV-2
SARS-CoV-2 RBD
SARS-CoV-2 S
SARS-CoV-2 S protein
SARS-CoV-2 virus
SARS-CoV-2 virus infection
Spike protein
SPR
Structure
structures
suggested
surface plasmon
surface plasmon resonance
Symptom
TCM
the SARS-CoV-2
therapeutic agents
these compound
these compounds
Traditional Chinese medicine
treat
viropexis
virus infection
were used
[DOI] 10.1016/j.jep.2021.114303 PMC 바로가기 [Article Type] Article
[DOI] 10.1016/j.jep.2021.114303 PMC 바로가기 [Article Type] Article