ER, endoplasmic reticulum – Communicable Diseases Research

The SARS-CoV2 envelope differs from host cells, exposes procoagulant lipids, and is disrupted in vivo by oral rinses

Research Article

Published on 2022-04-152023-06-16
Journal: Journal of Lipid Research
[Category] COVID19(2023년), MERS, SARS,

SARS-CoV-2 accessory protein ORF8 is secreted extracellularly as a glycoprotein homodimer

Article

Published on 2022-02-112023-06-16
Journal: The Journal of Biological Chemistry
[Category] COVID19(2023년), MERS, SARS,

Cetylpyridinium chloride (CPC) reduces zebrafish mortality from influenza infection: Super-resolution microscopy reveals CPC interference with multiple protein interactions with phosphatidylinositol 4,5-bisphosphate in immune function

Article

Published on 2022-02-092023-06-14
Journal: Toxicology and applied pharmacology
[Category] COVID19(2023년), MERS, SARS,

[키워드] Ag, antigen ATP, adenosine triphosphate BSA, bovine serum albumin BT, Tyrodes-bovine serum albumin cetylpyridinium chloride CMC, critical micelle concentration CPC, cetylpyridinium chloride CT, cytoplasmic tail DC, duct of Cuvier DNP, anti-dinitrophenyl dpf, days post fertilization dpi, days post infection ER, endoplasmic reticulum FPALM, fluorescence photoactivation localization microscopy HA, hemagglutinin hpf, hours post fertilization hpi, hours post-infection IAV, influenza type A virus IgE, immunoglobulin E Influenza IP₃, inositol 1,4,5-triphosphate LDH, lactate dehydrogenase MARCKS, myristoylated alanine-rich C-kinase substrate MDCK, Madin-Darby Canine Kidney NIH-3T3, mouse embryo fibroblast cells, 3-day transfer, inoculum 3 × 10⁵ cells PBS, phosphate buffered saline PH, pleckstrin homology Phosphatidylinositol 4,5-bisphosphate PIP₂, phosphatidylinositol 4,5-bisphosphate PLCγ, phospholipase C gamma PM, plasma membrane quaternary ammonium compound RBL-2H3, rat basophilic leukemia cells, clone 2H3 ROI, region of interest SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 SEM, standard error of the mean SOCE, store-operated Ca²⁺ entry Super-resolution microscopy zebrafish
[DOI] 10.1016/j.taap.2022.115913 PMC 바로가기 [Article Type] Article

Allotypic variation in antigen processing controls antigenic peptide generation from SARS-CoV-2 S1 spike glycoprotein

Research Article

Published on 2021-10-222022-10-30
Journal: The Journal of Biological Chemistry
[Category] COVID-19, SARS,

[키워드] acute respiratory syndrome Allotype allotypes Analysis analyzed antigen processing antigenic peptide antigenic peptides approach breadth Cell contribute Control coronavirus coronavirus disease COVID-19, coronavirus disease 19 Critical cytotoxic determinant Endoplasmic reticulum enzyme enzyme mechanism Epitopes ER, endoplasmic reticulum ERAP1 ERAP1, endoplasmic reticulum aminopeptidase 1 genetic variability glycoprotein hallmark heterogeneity histocompatibility complex HLA HLA, human leukocyte antigen immune response immune system gene Immunity individuals Infection Ligand mechanism MHC MHC, major histocompatibility complex Pathogens PCA, principal component analysis peptide peptides Population precursor produced producing Proteolytic processing proteomic proteomics PSM, peptide-spectrum match reaction regulate response SARS-CoV-2 S1 spike SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 sequence severity significant difference SNPs spike glycoprotein suggested T-lymphocyte trimming underlie vaccination Variability Variation while
[DOI] 10.1016/j.jbc.2021.101329 PMC 바로가기 [Article Type] Research Article

Exosome-mediated mRNA delivery in vivo is safe and can be used to induce SARS-CoV-2 immunity

Research Article

Published on 2021-10-012022-10-30
Journal: The Journal of Biological Chemistry
[Category] COVID-19, SARS,

[키워드] ACE2, angiotensin-converting enzyme II adverse effect antibody approach BCA, bicinchoninic acid BLI, bioluminescent imaging can be used Cationic lipid CDM, chemically defined media Cell cellular characterized COVID19 CTCS, clarified tissue culture supernatant CVS, concentrated vesicle suspension DOPE, dioleoyl phosphatidylethanolamine dose DOTAP, dioleoyl-3-trimethylammonium propane DTZ, diphenylterazine elicited encapsulation ER, endoplasmic reticulum EV, extracellular vesicle Evidence Exosome Exosomes Extracellular vesicles form functional had no human cell Humoral response HUVEC, human umbilical vein endothelial cell immunogenic induce injection Lipid nanoparticle lipofection LNP LNP, Lipid Nanoparticle long-lasting luciferase expression mice mRNA NTA, nanoparticle tracking analysis nucleocapsid ORF, open reading frame pfPBS, particle-free PBS previous study Protein repeated responses Safe SARS-CoV-2 immunity SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 SEC, size-exclusion chromatography Skeletal muscle spike sustained T-cell tested the SARS-CoV-2 tissue Toxicity vitreous fluid
[DOI] 10.1016/j.jbc.2021.101266 PMC 바로가기 [Article Type] Research Article

Receptor binding, immune escape, and protein stability direct the natural selection of SARS-CoV-2 variants

Research Article

Published on 2021-09-172023-06-15
Journal: The Journal of Biological Chemistry
[Category] MERS, SARS,

Recombinant SARS-CoV-2 envelope protein traffics to the trans -Golgi network following amphipol-mediated delivery into human cells

Accelerated Communication

Published on 2021-07-052022-10-30
Journal: The Journal of Biological Chemistry
[Category] COVID-19,

[키워드] trans-Golgi network acute respiratory syndrome AF488, Alexa Flour 488 amphipol antiviral therapies approach Cell cells cellular conserved coronavirus CoV CoV, coronavirus delivery disrupt E protein envelope envelope protein ER, endoplasmic reticulum ERGIC, ER–Golgi complex intermediate compartment expression human cell insertion ion channel LAMP1, lysosomal-associated membrane protein 1 Lysosomes membrane membrane protein Membrane proteins membranes NBD, nitrobenzoxadiazole NIH, National Institutes of Health Particle Pathogenesis plasma membrane Polymer progeny Protein purification recombinant S2-E-NBD, NBD-labeled S2-E S2-E, SARS-CoV-2 envelope protein SARS SARS-CoV-2 envelope SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 TGN, trans-Golgi network vesicles WGA, wheat germ agglutinin
[DOI] 10.1016/j.jbc.2021.100940 PMC 바로가기 [Article Type] Accelerated Communication

Antigen presentation in SARS-CoV-2 infection: the role of class I HLA and ERAP polymorphisms

Review

Published on 2021-05-102023-06-16
Journal: Human immunology
[Category] MERS, SARS,

[키워드] ACE2, angiotensin-converting enzyme-2 receptor ARDS, acute respiratory distress syndrome COVID-19, Coronavirus disease 2019 CTL, Cytotoxic T lymphocytes ER, endoplasmic reticulum ERAP, endoplasmic reticulum aminopeptidase ERAPs ERGIC, ER Golgi Intermediate Compartment GWAS, genome-wide association study HLA HLA, between Human Leukocyte Antigen IRAP, insulin-regulated aminopeptidase MERS-CoV, Middle East respiratory syndrome coronavirus MHC, major histocompatibility complex Polymorphisms RDB, receptor-binding domain SARS-CoV-2 SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 SNP, single nucleotide polymorphism, NMD, nonsense-mediated-decay TAP, transporter associated with antigen processing TMPRSS2, type II transmembrane serine protease WHO, World Health Organization
[DOI] 10.1016/j.humimm.2021.05.003 PMC 바로가기 [Article Type] Review

Dissecting lipid metabolism alterations in SARS-CoV-2

Review

Published on 2021-02-082023-06-15
Journal: Progress in lipid research
[Category] MERS, SARS,

[키워드] AA, arachidonic acid ACE2, angiotensin-converting enzyme 2 AUC, area under curve coronavirus COVID-19 COVID-19, coronavirus disease 19 cPLA2 α, cytosolic phospholipase A2α CTD, C-terminal domain DAGs, diacylglycerols DHA, C22:6 docosahexaenoic acid DIC, disseminated intravascular coagulation DMV, double-membrane vesicles DPA, C22: 5 docosapentaenoic acid DVT, deep vein thrombosis dyslipidaemia EBOV, Ebola virus EPA, C20:5 eicosapentaenoic acid ER, endoplasmic reticulum ERGIC, ER-Golgi intermediate compartment GM3, monosialodihexosyl ganglioside HDL, high density lipoproteins IDL, intermediate density lipoproteins IFNα, interferon α ISTH, International Society on Thrombosis and Haemostasis LC-MS, liquid chromatography LDs, lipid droplets lipid metabolism LMs, lipid mediators LPA, lysophosphatidic acid LPC, lysophosphatidylcholine LPE, lysophosphatidylethanolamine LPLs, Lysophospholipids MCS, membrane contact site MERS-CoV, Middle East respiratory syndrome coronavirus MVB, multivesicular body NEFAs, non-esterified fatty acids NET, neutrophil extracellular trap NPC1, receptor Niemann-Pick C1 NTD, N-terminal domain ORF, open-reading frame PAF, platelet-activating factor PAs, phosphatidic acids PCs, phosphatidylcholines PEs, phosphoethanolamines PI3K, phosphoinositide 3-kinase PLA2, phospholipase A2 plasmenyl-PC, plasmenyl phosphatidylcholine PSTPIP2, proline-serine-threonine phosphatase-interacting protein 2 PtdIns, Phosphoinositides PtdIns(3,5)P₂, bisphosphate phosphatidylinositol 3,5-bisphosphate PtdIns3P, monophosphate phosphatidylinositol 3-phosphate PUFAs, poly-unsaturated fatty acids QqQ, triple quadrupoles RBD, receptor-binding domain RO, replication organelles RvE3, resolvin E3 S protein, spike protein S1P, sphingosine 1-phosphates SARS-CoV-2 SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 SARS-CoV, severe acute respiratory syndrome SMs, sphingomyelins SPE, solid-phase extraction SPME, solid-phase microextraction SREBPs, sterol regulatory element-binding proteins TAGs, triacylglycerols TC, total cholesterol TMPRSS2, type II transmembrane serine host cell protease VLDL, very low-density lipoproteins VTE, venous thromboembolism.
[DOI] 10.1016/j.plipres.2021.101092 PMC 바로가기 [Article Type] Review

Screening for natural and derived bio-active compounds in preclinical and clinical studies: One of the frontlines of fighting the coronaviruses pandemic

Review

Published on 2020-08-292023-07-01
Journal: Phytomedicine : international journal of phytother
[Category] SARS,

[키워드] 3CL^pro, 3C-Like protease ACE2, angiotensin-converting enzyme 2 Antiviral ARDS, acute respiratory distress syndrome CC₅₀, Half maximal cytotoxic concentration CD13, Human aminopeptidase N receptor clinical trials COVID-19 COVID-19, Corona virus disease 2019 DPP4, dipeptidyl peptidase 4 EC₅₀, half maximal effective concentration ER, endoplasmic reticulum EtOAc, Ethyl acetate EtOH, Ethanol FDA, Food and Drug Administration HCoV-229E, human coronavirus 229E HCoV-HKU1, Human coronavirus Hong Kong University 1 HCoV-NL63, human coronavirus NL63 HCoV-OC43, human coronavirus OC43 HIV, Human immunodeficiency virus IC₅₀, Half maximal inhibitory concentration IL-6, interleukin 6 IL-6R, Interleukin-6 receptor MERS-CoV, Middle East respiratory syndrome coronavirus MHV-A59, Coronavirus Murine hepatitis virus N, Unaltered natural product natural products ND, Natural product derivative Nsp3, Non-structural proteins proteases 3 Nsp5, Non-structural proteins proteases 5 ORF1a/b, Nonstructural open‐reading frames Patent protection RdRp, RNA dependent RNA polymerase RNA, Ribonucleic acid SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 SARS-CoV, severe acute respiratory syndrome coronavirus TEM, Transmission electron microscope
[DOI] 10.1016/j.phymed.2020.153311 PMC 바로가기 [Article Type] Review