The S1 spike protein of SARS-CoV-2 upregulates the ERK/MAPK signaling pathway in DC-SIGN-expressing THP-1 cellsResearch Paper Published on 2024-03-052024-09-05 Journal: Cell stress & chaperones [Category] update2024, [키워드] DC-SIGN dendritic cell ERK NF-κB SARS-CoV-2 S1 [DOI] 10.1016/j.cstres.2024.03.002 PMC 바로가기 [Article Type] Research Paper
Hypoxia signaling in human health and diseases: implications and prospects for therapeutics Reviews Published on 2022-07-072022-10-05 Journal: Signal Transduction and Targeted Therapy [Category] 신약개발, [키워드] Activation addition biological processes Cancer Cell cell metabolism cell proliferation cellular pathways change Chronic diseases disease Diseases downstream gene drugs Endoplasmic reticulum ERK expression Extracellular Factor Glycolysis Health hypoxia immune response implication Infection interact involved kinase mammalian cells mechanism Metastasis microbe Molecular oxygen NF-κB nuclear oxygen pathogenic pathway question Rapamycin reaction regulate respond responses Signaling Stress subsequent therapeutic therapeutic target tumorigenesis [DOI] 10.1038/s41392-022-01080-1 [Article Type] Reviews
Scutellarein Inhibits LPS-Induced Inflammation through NF-κB/MAPKs Signaling Pathway in RAW264.7 Cells스쿠텔라레인은 RAW264.7 세포에서 NF-κB/MAPK 신호 전달 경로를 통해 LPS 유도 염증을 억제합니다Article Published on 2022-06-122022-09-11 Journal: Molecules [Category] 유전자 메커니즘, [키워드] addition Anti-inflammatory can be used Cell cells Chinese composed Compound COVID-19 Cyclooxygenase cytokine Cytokines determine diploid endotoxin ERK expression Extracellular family Gram-negative bacteria Helicase IL-1β Immune cell immune cells immune system Inflammation Inflammatory inflammatory disorder inflammatory disorders inhibit interleukin interleukin-1β involved IκBα JNK kinases lipopolysaccharide LPS LPS-induced inflammation MAPK mechanism mitogen NF-kB NF-кB nitric oxide nitric oxide synthase no effect nuclear outer membrane p65 pathway Pathways pro-inflammatory mediators proinflammatory mediators protein kinase required SARS Coronavirus SCU scutellarein scutellarein (SCU). secretion shown stimulate stimulated TNF-α Topic treat Treatment Tumor tumor necrosis tumor necrosis factor tumor necrosis factor-α was reduced western blot [DOI] 10.3390/molecules27123782 PMC 바로가기 [Article Type] Article
Inhibition of IRAK4 dysregulates SARS-CoV-2 spike protein-induced macrophage inflammatory and glycolytic reprogrammingIRAK4의 억제는 SARS-CoV-2 스파이크 단백질 유도 대식세포 염증 및 해당과정 재프로그래밍을 조절하지 못함Article Published on 2022-05-192022-09-11 Journal: Cellular and Molecular Life Sciences [Category] Coronavirus, COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, [키워드] ACE2 activate AKT baseline blockade CCL2 cells citrate counteract Critical dysregulated ERK expression Glycolysis human SARS-CoV-2 Hyperactivation IL-6 IL-8 impair independent Inflammatory Inflammatory marker inflammatory markers inhibition inhibitor Innate immunity irak4 IRAK4 inhibitor IRF5 IRF7 knockdown Lactate LDHA Macrophage macrophages metabolic activity mitochondrial Mitochondrial oxidative phosphorylation molecular mechanism monokines murine models NF-κB NF-κB activation oxidative oxidative phosphorylation phenotype Phosphorylation promoted Protein reduction response responsible reversal SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein severe COVID-19 patient severe COVID-19 patients shown Signaling siRNA spike Spike protein succinate suppression Therapeutic strategies therapy TLR TLR-mediated TLR2 TLR7 TLRs TNFα treated Treatment triggered without affecting [DOI] 10.1007/s00018-022-04329-8 PMC 바로가기 [Article Type] Article
DExD/H-box helicase 9 intrinsically controls CD8 + T cell-mediated antiviral response through noncanonical mechanismsDExD/H-box 헬리카제 9는 비정규 메커니즘을 통해 본질적으로 CD8 + T 세포 매개 항바이러스 반응을 제어합니다Article Published on 2022-02-112022-09-11 Journal: Science Advances [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] activated Activation antiviral immunity antiviral response Apoptosis binding CD8 Control Coordinate COVID-19 patients DHX9 domain effector effector cell ERK event expression Helicase independent independent of intrinsically LCK mechanism nuclear Phosphorylation proliferation proliferative promote PROTECT regulate Regulatory required survival T cell T cells TCR Transcription viral clearance virus infection ZAP70 [DOI] 10.1126/sciadv.abk2691 PMC 바로가기 [Article Type] Article
Long-Term Dietary Taurine Lowers Plasma Levels of Cholesterol and Bile AcidsArticle Published on 2022-02-042023-08-30 Journal: International Journal of Molecular Sciences [Category] E형 간염, [키워드] bile acid cholesterol CYP7A1 ERK FGF21 Taurine [DOI] 10.3390/ijms23031793 PMC 바로가기 [Article Type] Article
TLR2 senses the SARS-CoV-2 envelope protein to produce inflammatory cytokinesArticle Published on 2022-01-222023-06-18 Journal: Nature Immunology [Category] Fulltext, SARS, [키워드] β-Coronavirus COVID-19 Cytokine storm envelope protein ERK IFN-γ Inflammation Inflammatory cytokines MHV NF-κB SARS-CoV-2 TLR2 TNF-α [DOI] 10.1038/s41590-021-00937-x PMC 바로가기 [Article Type] Article
Insights Into Amentoflavone: A Natural Multifunctional BiflavonoidPharmacology Published on 2021-12-222022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] activity addition amentoflavone anti-cancer Anti-inflammatory anti-SARS-CoV-2 Biflavonoid binding Bioavailability biological activities biological activity cancers drug delivery ERK Extracellular in silico Approach insight metabolism molecular docking molecular mechanism molecular target multifunctional Musculoskeletal natural NF-κB nuclear protease RBD RdRP Receptor binding domain recorded Regulation Research RNA-dependent RNA polymerase SARS-CoV-2 Selaginella tamariscina signaling pathway Spike protein therapeutic [DOI] 10.3389/fphar.2021.768708 PMC 바로가기 [Article Type] Pharmacology
The ERK-p38MAPK-STAT3 Signalling Axis Regulates iNOS Expression and Salmonella Infection in Senescent CellsERK-p38MAPK-STAT3 신호 축이 노화 세포에서 iNOS 발현과 살모넬라 감염을 조절한다.Original Research Published on 2021-10-222024-07-29 Journal: Frontiers in Cellular and Infection Microbiology [Category] 살모넬라증, [키워드] ERK iNOS p38 MAPK Salmonella Typhimurium senescence Signalling STAT3 [DOI] 10.3389/fcimb.2021.744013 PMC 바로가기 [Article Type] Original Research
Potential Adjuvant Therapeutic Effect of Lactobacillus plantarum Probio-88 Postbiotics against SARS-COV-2Article Published on 2021-09-242022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] Lactobacillus plantarum adjuvant antiviral activity approach association binding binding affinity Cell conducted coronavirus COVID-19 COVID-19 pandemic develop drug Effect Efficacy effort ERK evaluated Helicase IFN-α IFN-β IL-6 immune regulation in silico in vitro indicated infected cells Infection Inflammatory Inflammatory marker inhibited lactobacillus Microbiome molecular docking pathogen plantaricin postbiotics Potential Prevent reactive oxygen specy reduction in Replication ROS SARS-CoV-2 severity significantly Spread tested Therapeutic approach treated Vaccine variants viral replication virus while [DOI] 10.3390/vaccines9101067 PMC 바로가기 [Article Type] Article