erythropoiesis – Communicable Diseases Research

Differential Impact of SARS-CoV-2 Isolates, Namely, the Wuhan Strain, Delta, and Omicron Variants on Erythropoiesis

Article

Published on 2022-08-312022-11-16
Journal: Microbiology Spectrum
[Category] SARS, 변종,

[키워드] ACE2 Affect Blood blood circulation Bone marrow CD45 CD8 Cell COVID-19 patient COVID-19 patients degranulation Delta disease severity dominant erythropoiesis erythropoiesis. Express expressing expression Frequency function functions granzyme hallmark Hematopoiesis hypoxia immature immunosuppressive immunosuppressive properties Impact impair in vitro investigated omicron oxygen Patient prevalent provide RBC RBCs reactive oxygen specy receptor red blood cell reversed ROS SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants significantly strain subpopulation suppress T cell the SARS-CoV-2 these cell tissues TMPRSS2 Transmissibility variant variants Wuhan Wuhan strain
[DOI] 10.1128/spectrum.01730-22 PMC 바로가기

In Vivo Hematopoietic Stem Cell Gene Therapy for SARS-CoV2 Infection Using a Decoy Receptor

유인 수용체를 사용한 SARS-CoV2 감염에 대한 생체 내 조혈 줄기 세포 유전자 치료

Article

Published on 2022-04-012022-09-11
Journal: Human gene therapy
[Category] COVID19(2023년), SARS, 변종,

[키워드] abundance Adenovirus adjust airway Antiviral antiviral efficacy approach approaches Bone marrow CD46 Cell creating cytokine cytokine production decoy decoy receptor diminishe dose effector proteins elements erythrocytes erythroid cells erythropoiesis example expressed expression Gene therapy hematopoietic Hematopoietic stem cell hematopoietic system in vivo in vivo HSC gene therapy. Infection Intervention Intravenous injection less lethal dose Lung pathology mice neutralizing capacity not affect performed Peripheral blood pilot study Prophylaxis reached receptor receptor protein reduced Regulatory resulting rhesus rhesus macaque sACE2 SARS-CoV2 SARS-CoV2 infection SARS-CoV2 vaccine SARS-CoV2 vaccines secreted shown significantly spleen STEM stem cell survived susceptible Symptoms therapy transcriptional transduced Vaccine variant Viremia while β-globin
[DOI] 10.1089/hum.2021.295 PMC 바로가기 [Article Type] Article

Hematopoietic responses to SARS-CoV-2 infection

Review

Published on 2022-03-132023-06-16
Journal: Cellular and Molecular Life Sciences
[Category] MERS, SARS,

[키워드] COVID-19 Cytokine storm erythropoiesis Hematopoietic stem and progenitors Stress hematopoiesis
[DOI] 10.1007/s00018-022-04220-6 PMC 바로가기 [Article Type] Review

Human Erythroid Progenitors Are Directly Infected by SARS-CoV-2: Implications for Emerging Erythropoiesis in Severe COVID-19 Patients

인간 적혈구 전구 세포가 SARS-CoV-2에 직접 감염됨: 중증 COVID-19 환자의 적혈구 생성에 대한 시사점

Report

Published on 2021-02-052022-09-10
Journal: Stem Cell Reports
[Category] MERS, SARS, 치료기술, 치료제,

[키워드] ACE2 ACE2 expression Anemia Bone marrow cause CD34 Cell cells circulating circulation clinical symptom Clinical symptoms colonies colony contribute COVID-19 COVID-19 patient COVID19 defined erythroid erythropoiesis expansion hemoglobin highest Human human hematopoietic stem/progenitor cells hypoxia impairing increase in induce infect Infection initial intensive care local inflammation nucleated red cells progenitor progenitor cell red blood cell red blood cells reduced SARS-CoV-2 SARS-COV-2 infection severe COVID-19 severe COVID-19 patient severe COVID-19 patients Severe patient Spread Stress target cell the patient these cell These cells tissues TMPRSS2 virus
[DOI] 10.1016/j.stemcr.2021.02.001 PMC 바로가기 [Article Type] Report

Prognosis of COVID-19: Red Cell Distribution Width, Platelet Distribution Width, and C-Reactive Protein

Internal Medicine

Published on 2021-02-022022-10-31
Journal: Cureus
[Category] COVID-19,

[키워드] Acute inflammation Admission affected age alteration association Autoimmune baseline C-reactive protein C-reactive protein (CRP category Cell Cell-mediated immunity circulation Clinical outcome college conducted Coronavirus disease 2019 COVID COVID-19 COVID-19 patient CRP Deceased Diagnosis disease disrupt distribution enrolled erythropoiesis family Government of India hematocrit hypoxia immature immune response increase increased mortality Infection Inflammation Lower malignancy management marker mechanical ventilation Ministry of Health moderate Mortality MPV Negative predictive value non-specific non-survivor outcome Patient patients Platelet platelet distribution width Predictive pro-inflammatory state Prognosis prognostic progression raised Red Red cell Red cell distribution width responsible Result Retrospective cross-sectional study sensitivity significantly study population survived survivor the disease Volume Welfare width
[DOI] 10.7759/cureus.13078 PMC 바로가기 [Article Type] Internal Medicine

HIF Prolyl Hydroxylase Inhibitors for COVID-19 Treatment: Pros and Cons

Pharmacology

Published on 2021-01-292022-10-31
Journal: Frontiers in Pharmacology
[Category] COVID-19,

Longitudinal Multi-omics Analyses Identify Responses of Megakaryocytes, Erythroid Cells, and Plasmablasts as Hallmarks of Severe COVID-19

세로 다중 오믹스 분석을 통해 거핵구, 적혈구계 세포 및 형질모세포의 반응을 중증 COVID-19의 특징으로 식별

Article

Published on 2020-12-152022-09-11
Journal: Immunity
[Category] MERS, SARS, 바이오마커, 유전자 메커니즘, 진단,

[키워드] acute respiratory distress adaptive analyzed BCR Biomarker Biomarkers Blood cells cellular characterized circulating co-expression Cohort COVID-19 COVID-19 disease COVID-19 patients Critical Critical illness disease disease trajectory DNA Effect erythroid erythropoiesis expansion fatal disease feature hallmark hypoxic immune Immune cell immune cells immune response immune responses independent Infectious disease interferon longitudinal megakaryocyte Methylation outcome patients patients with COVID-19 performed Peripheral blood peripheral blood samples plasmablast plasmablasts Predictive predictor profiles provide respiratory respiratory distress response RNA-Seq SARS-COV-2 infection scRNA-seq severe COVID-19 severe COVID-19 disease Signaling single-cell skewed Temporal Temporal resolution trajectory Transcriptome Treatment validation virus virus. was performed
[DOI] 10.1016/j.immuni.2020.11.017 PMC 바로가기 [Article Type] Article

Revisiting the treatment of anemia in the setting of chronic kidney disease, hematologic malignancies, and cancer: perspectives with opinion and commentary

Review

Published on 2020-11-012023-07-12
Journal: Expert review of hematology
[Category] SARS,

[키워드] Anemia Management Cancer cancer-Induced Anemia Chronic kidney disease erythropoiesis erythropoiesis Stimulating Agents erythropoietin Hemodialysis Treatment guidelines.
[DOI] 10.1080/17474086.2020.1830371 PMC 바로가기 [Article Type] Review

Coronavirus disease 2019 induces multi‐lineage, morphologic changes in peripheral blood cells

Research Article

Published on 2020-06-292022-10-31
Journal: Ejhaem
[Category] COVID-19,

[키워드] acute respiratory distress Analysis analyzed Blood blood differential count caused change changes in characteristic Clinical course coagulation disorder Cohort conducted coronavirus disease Coronavirus disease 2019 COVID‐19 COVID‐19 patient COVID‐19 patients COVID‐19 Critical defined diagnostic electron microscopy erythropoiesis exhibited facilitate flow cytometry hemato‐morphology hematologic hyperinflammation independent induce intensive care light microscopy lymphocyte median age Microscopy Mild symptom monocyte patients Peripheral blood peripheral blood cell peripheral blood smear SARS‐CoV‐2 severely ill patients syndrome was performed
[DOI] 10.1002/jha2.44 PMC 바로가기 [Article Type] Research Article