estrogen receptor
[용어속성] Term
Antiviral efficacy of selective estrogen receptor modulators against SARS-CoV-2 infection in vitro and in vivo reveals bazedoxifene acetate as an entry inhibitor
시험관 내 및 생체 내에서 SARS-CoV-2 감염에 대한 선택적 에스트로겐 수용체 조절제의 항바이러스 효능은 진입 억제제로서 바제독시펜 아세테이트를 나타냅니다
Article
[키워드] Acetate
acute respiratory syndrome
acute respiratory syndrome coronavirus
acute respiratory syndrome coronavirus 2
anti-SARS-CoV-2
antiviral efficacy
Bazedoxifene
bazedoxifene acetate
candidate
cholesterol
cholesterol distribution
citrate
clinical
Clomifene
Clomifene citrate
contagious
coronavirus
Coronaviruses
Critical
delta variant
distribution
drugs
Effect
Efficacy
endosome acidification
Estrogen
estrogen receptor
evaluated
exhibited
expression
hamster
hamsters
human cell lines
humans
identify
in vitro
in vivo
infect
Infection
information
inhibited
inhibitor
interleukin-6
offer
omicron
Omicron variant
pathogenic variant
penetration
Postinfection
pseudovirus
pseudoviruses
pulmonary viral
reduced
reveal
SARS-CoV
SARS-CoV-2
SARS-COV-2 infection
selective
selective estrogen receptor modulator
severe acute respiratory syndrome Coronavirus
severe acute respiratory syndrome coronavirus 2
Tamoxifen
toremifene
toremifene citrate
variant
Vero E6
Vero E6 cell
VERO E6 cells
weight loss
[DOI] 10.1002/jmv.27951 PMC 바로가기 [Article Type] Article
[DOI] 10.1002/jmv.27951 PMC 바로가기 [Article Type] Article
Dispensing anti-osteoporotic drugs changed during the COVID-19 pandemic
COVID-19 대유행 기간 동안 변경된 골다공증 치료제 조제
Observational Study
[키워드] alendronate
alteration
Analysis
Anti-osteoporotic therapy
ARIMA
Austria
Autoregressive integrated moving average models
average
bisphosphonate
Bisphosphonates
changed
clinician
COVID-19
COVID-19 pandemic
declined
decrease
Dispensing
DMAB
drug
estrogen receptor
intravenous
lockdown
medication
Non-COVID-19
observation
occurred
Osteoporosis
pandemic
Patient
patients treated
predict
predicted
prescription
Pseudonymised
repeated
retrospective
risk
selective
Treatment
treatment regimen
[DOI] 10.1016/j.bone.2022.116477 PMC 바로가기 [Article Type] Observational Study
[DOI] 10.1016/j.bone.2022.116477 PMC 바로가기 [Article Type] Observational Study
Periodontitis promotes the expression of gingival transmembrane serine protease 2 (TMPRSS2), a priming protease for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
치주염은 중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2)에 대한 프라이밍 프로테아제인 치은 막횡단 세린 프로테아제 2(TMPRSS2)의 발현을 촉진합니다
Article
[키워드] acute respiratory syndrome
Analysis
analyzed
anti-TMPRSS2
antibody
cell membrane
ChIP
coronavirus
correlation
COVID-19
dataset
datasets
ESR1
Estrogen
estrogen receptor
Express
expressed
expression
Gene Expression
Gene Expression Omnibus
GEO
GEO dataset
Gingiva
Human
increase
increased expression
investigated
keratinocytes
Ligand
oral cavity
Periodontitis
priming
promote
promoter
promoter region
protease
Quantitative
responsible
reverse transcription
SARS-CoV-2
SARS-CoV-2 spike protein
screened
Serine
Spike protein
the SARS-CoV-2
tissue
tissues
TMPRSS2
TMPRSS2 expression
transcription factor
transcription factors
transmembrane serine protease
transmembrane serine protease 2
was performed
western blot
Western blot analysis
[DOI] 10.1016/j.job.2022.04.004 PMC 바로가기 [Article Type] Article
[DOI] 10.1016/j.job.2022.04.004 PMC 바로가기 [Article Type] Article
Drugs repurposed: An advanced step towards the treatment of breast cancer and associated challenges
Review article
[키워드] coiled-coil-containing protein kinase 1
17β-HSD17β-Hydroxysteroid dehydrogenase specificity
17β-Hydroxysteroid dehydrogenase specificity
3β-HSD3β-Hydroxysteroid dehydrogenase specificity
3β-Hydroxysteroid dehydrogenase specificity
4-Hydroxy-trans-2-NonEnal
8-Oxo-2'-deoxyguanosine
8-Oxo-dG8-Oxo-2'-deoxyguanosine
AAArachidonic acid
ABCATP Binding Cassette
ABCG2ATP-binding cassette superfamily G member 2
active transport
adverse effect
AEadverse effect
ALSAmyotrophic lateral sclerosis
Amyotrophic lateral sclerosis
anthracyclines
arachidonic acid
ATactive transport
ATP Binding Cassette
ATP-binding cassette superfamily G member 2
BCBreast cancer
beta actin
BRAC1breast cancer type 1
Breast
Breast cancer
breast cancer type 1
Cancer
cancer causing genes
Cancer stem cells
cancerous cells
candidate
CCcancerous cells
CCGscancer causing genes
CDKcyclin-dependent kinase
clinical trials
complications
Computational approaches
costly
COX-2Cyclo-oxygenase 2
CSCscancer stem cells
CTsclinical trials
cyclin-dependent kinase
Cyclo-oxygenase 2
DBFdrug binding frequency
DBSdrug binding site
death
Dehydroepiandrosterone
Dehydroepiandrosterone sulfate
DHEADehydroepiandrosterone
DHEASDehydroepiandrosterone sulfate
Di phosphomevalonate decarboxylase
Diabetes Mellitus
DIdrug induced
DMDiabetes mellitus
DNA Topoisomerase II Alpha
DRdrug resistance
drug
drug binding frequency
drug binding site
drug induced
drug resistance
drug transporters
DTsdrug transporters
ECMextra cellular matrix
EHRselectronic health records
Electronic health records
EMTEpithelia-Mesenchymal transition
EP1prostaglandin E2 receptor 1
Epithelia-Mesenchymal transition
ER+Estrogen Receptor-Positive
ERCC2Excision repair cross-complementing group 2
EREsestrogen receptor binding elements
ERestrogen receptor
ERKextracellular signal-regulated kinases
estrogen receptor
estrogen receptor binding elements
Estrogen Receptor-Positive
Excision repair cross-complementing group 2
extra cellular matrix
extracellular signal-regulated kinases
Factors
FAKfocal adhesion kinase
focal adhesion kinase
glutathione S-transferase
Glycogen synthase kinase 3 beta
GSKβGlycogen synthase kinase 3 beta
GSTglutathione S-transferase
H-rasHarvey Rat sarcoma virus
Harvey Rat sarcoma virus
HDHuntington disease
HER1/2Human epidermal growth factor receptor 1/2
HER2-Human Epidermal growth factor receptor 2 negative
HER2+Human Epidermal growth factor receptor 2 positive
HERhuman epidermal growth factor receptor
HMG-CoA reductase
HMG-CoA Synthase
HMGCRHMG-CoA reductase
HMGCSHMG-CoA Synthase
HNE4-Hydroxy-trans-2-NonEnal
HPTHypertension
human epidermal growth factor receptor
Human epidermal growth factor receptor 1/2
Human Epidermal growth factor receptor 2 negative
Human Epidermal growth factor receptor 2 positive
Huntington disease
hypertension
IBDInflammatory bowel disease
IGF-1insulin-like growth factor 1
Inflammatory bowel disease
information
inhibitor
insulin-like growth factor 1
Lanosterol synthase
LHRHluteinizing hormone-releasing hormone
LSSLanosterol synthase
luteinizing hormone-releasing hormone
malignant cells
malondialdehyde
mammalian target of rapamycin
MAPKmitogen- activated protein kinase
matrix metalloproteinase
MCmalignant cells
MDAmalondialdehyde
MDmedian duration
MDRmulti-drug resistance
median duration
membrane transporters
MetAP2methionine aminopeptidase-2
methionine aminopeptidase-2
MHS2MutS Homolog 2
microtubules
mitogen- activated protein kinase
mitoxantrone resistant cells
MLH1MutL homolog 1
MMPmatrix metalloproteinase
molecular mechanism
Mortality
MRCmitoxantrone resistant cells
MTmicrotubules
mTORmammalian target of rapamycin
MTsmembrane transporters
multi-drug resistance
MutL homolog 1
MutS Homolog 2
MVDDi phosphomevalonate decarboxylase
NAD(P)H dehydrogenase [quinone] 1
NCCnon-cancerous cells
NCENew chemical entity
New chemical entity
NF-κBNuclear factor kappa-light-chain-enhancer of activated B cell
Nitric Oxide Synthase 3
non-cancerous cells
Non-profit organisations
non-steroidal anti-inflammatory medicine
NOS3Nitric Oxide Synthase 3
NPONon-profit organisations
NQO1NAD(P)H dehydrogenase [quinone] 1
NSAIDnon-steroidal anti-inflammatory medicine
Nuclear factor kappa-light-chain-enhancer of activated B cell
occur
OCT1organic cation transporter 1
organic cation transporter 1
P-glycoprotein
P-gpP-glycoprotein
p53Tumor protein p53
PEG2/PGH2prostaglandin E2
PR+Progesterone Positive
Progesterone Positive
progesterone receptor
prostaglandin E2
prostaglandin E2 receptor 1
proteomics
provide
PRprogesterone receptor
Rac1Ras-related C3 botulinum toxin substrate 1
Randomised clinical trials
Ras homolog family member A
Ras-related C3 botulinum toxin substrate 1
RCTsRandomised clinical trials
reactive oxygen species
Receptor tyrosine kinase
Repurposed drug
responsible
Rho-ARas homolog family member A
rho-associated
Ribosomal protein S6 kinase
rising
ROCK1rho-associated
ROSreactive oxygen species
RTKReceptor tyrosine kinase
S6KRibosomal protein S6 kinase
Scientific community
SCstromal cells
SCTssolute carrier transporters
selective estrogen receptor degrader
selective estrogen receptor modulator
sequential strategies
SERDselective estrogen receptor degrader
SERM
Side effects
signal transducer and activator of transcription 3
SIRT1/2sirtuin (silent mating type information regulation 2 homolog) ½
sirtuin (silent mating type information regulation 2 homolog) ½
SLC22A16Solute Carrier Family 22 Member 16
SMAD 2/3/4SMAD family member 2/3/4
SMAD family member 2/3/4
Solute Carrier Family 22 Member 16
solute carrier transporters
Sp1/3/4specificity protein 1/3/4
specificity protein 1/3/4
SQLESqualene monooxygenase
Squalene monooxygenase
SSsequential strategies
STAT3signal transducer and activator of transcription 3
stromal cells
subject
survival
TAEtopoisomerase alteration expression
Tamoxifen
TAMTamoxifen
TCtumour cells
TGFαTransforming growth factor-alpha
TGFβ-RITransforming growth factor-beta type 1 receptor
TGFβ1/β2Transforming growth factor beta1/2
TOP2ADNA Topoisomerase II Alpha
topoisomerase alteration expression
TP53tumor protein
Transforming growth factor beta1/2
Transforming growth factor-alpha
Transforming growth factor-beta type 1 receptor
Treatment
treatment-related side effects
TRPtumour resistance profile
TSEtreatment-related side effects
tumor protein
Tumor protein p53
tumour cells
tumour resistance profile
vascular endothelial growth factor
VEGFvascular endothelial growth factor
women
xanthine dehydrogenase
XDHxanthine dehydrogenase
β-actbeta actin
[DOI] 10.1016/j.biopha.2021.112375 [Article Type] Review article
[DOI] 10.1016/j.biopha.2021.112375 [Article Type] Review article
Repurposing the estrogen receptor modulator raloxifene to treat SARS-CoV-2 infection
SARS-COV-2 감염을 치료하기 위해 에스트로겐 수용체 조절제 Raloxifene을 재구성
Review
[키워드] acute respiratory syndrome
acute respiratory syndrome coronavirus
acute respiratory syndrome coronavirus 2
Anti-inflammatory
antiviral properties
attack rate
candidate
caused
clinical development
clinical trial
clinical trials
coronavirus
coronavirus disease
Coronavirus disease 2019
COVID-19
COVID-19 patients
Drug development
Efficacy
endurance
eradication
Estrogen
estrogen receptor
identify
immune memory
Infection
Infectious diseases
pandemic
Prophylactic
raloxifene
repurposing
respiratory
SARS-CoV-2
SARS-COV-2 infection
selective
therapeutic drug
treat
Treatment
Vaccine
Vaccines
virus
[DOI] 10.1038/s41418-021-00844-6 PMC 바로가기 [Article Type] Review
[DOI] 10.1038/s41418-021-00844-6 PMC 바로가기 [Article Type] Review
Estrogen Receptor Modulators in Viral Infections Such as SARS−CoV−2: Therapeutic Consequences
Review
[키워드] Activation
addition
caused
complex
consequence
coronavirus
COVID-19
cytokine
Cytokine storm
Effect
Estrogen
estrogen receptor
females
Hormones
Hypothesis
IL-6
include
inhibit
Interaction
knowledge
male
modulator
Mortality
organism
pandemic
patient’s death
protective effect
receptor complex
Respiratory disease
responsible
SARS−CoV−2
severe disease progression
the cytokine storm
therapeutic
viral replication
while
[DOI] 10.3390/ijms22126551 PMC 바로가기 [Article Type] Review
[DOI] 10.3390/ijms22126551 PMC 바로가기 [Article Type] Review
iPSC screening for drug repurposing identifies anti‐RNA virus agents modulating host cell susceptibility
Research Article
[키워드] antiviral activity
Antiviral effect
blocked
cells
Combination
Compound
conducted
demonstrated
drug
drugs
Ebola virus
Efficacy
estrogen receptor
evaluated
exhibited
genomic RNA
host cell
host cells
Huh7 cell
Human
Human immune system
human iPSC
identify
Infection
infections
inhibitory effect
local outbreak
modulate
modulating
mutated
Mutation
Pandemics
Paramyxoviridae
pathogenic
pioglitazone
pluripotent stem cell
PPARγ
PPARγ
public health
Repurposed drug
RNA virus
RNA viruses
SARS‐CoV‐2
SARS‐CoV‐2
Sendai virus
SERMs
susceptibility
synergistic
therapeutic
therapeutic potential
threat
Vaccine
Vero E6 cell
VERO E6 cells
Viral diseases
virus
viruses
while
[DOI] 10.1002/2211-5463.13153 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1002/2211-5463.13153 PMC 바로가기 [Article Type] Research Article
SARS-Cov2 S Protein Features Potential Estrogen Binding Site
Preliminary Communications
[키워드] 3D structure
Affect
appear
approach
average
binding
binding site
compare protein
conserved
contribute
coronavirus
domain
Epidemics
estradiol
Estrogen
estrogen binding site
estrogen receptor
Fatality rate
feature
Hopefully
immune response
Infection
involved
membrane fusion
men
MERS
notable
pandemic
Potential
Proteins
receptor
reducing
Result
S protein
SARS-CoV2
sequence
severity
similarity
Site
Surface glycoprotein
Symptom
the Coronaviridae
the disease
the S protein
virus infectivity
women
[DOI] 10.17113/ftb.59.01.21.6820 PMC 바로가기 [Article Type] Preliminary Communications
[DOI] 10.17113/ftb.59.01.21.6820 PMC 바로가기 [Article Type] Preliminary Communications