Detection of positive selection acting on protein surfaces at the whole-genome scale in the human malaria parasite Plasmodium falciparumarticle Published on 2023-01-312024-09-01 Journal: Infection, Genetics and Evolution [Category] 말라리아, [키워드] AlphaFold dN/dS evolutionary arms race malaria parasites Positive selection [Article Type] article
Hepatitis B virus (HBV) codon adapts well to the gene expression profile of liver cancer: an evolutionary explanation for HBV’s oncogenic roleArticle Published on 2022-11-012022-11-16 Journal: Journal of microbiology (Seoul, Korea) [Category] B형 간염, COVID19(2023년), SARS, 유전자 메커니즘, [키워드] addition Arm association CAI calculated cells codon adaptation index codon adaptation index (CAI) codon usage correlation evolutionary arms race expressed gene gene expression profile HAV HBV HCC HCV Hepatitis hepatitis viruses Hepatocellular carcinoma hepatocellular carcinoma (HCC) highest Host human genes human tissues initial liver liver cell Lungs oncogenesis oncogenic Perspective relative synonymous codon usage (RSCU). Replication RNA SARS-CoV-2 synonymous translation tRNA Viral proteins Viral RNA virus viruses [DOI] 10.1007/s12275-022-2371-x PMC 바로가기
Structure of a Vaccine-Induced, Germline-Encoded Human Antibody Defines a Neutralizing Epitope on the SARS-CoV-2 Spike N-Terminal Domain백신 유도 생식계열 인코딩 인간 항체의 구조는 SARS-CoV-2 스파이크 N-말단 도메인에서 중화 에피토프를 정의합니다Article Published on 2022-06-282022-09-11 Journal: mBio [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] (Alpha) (Beta) activated acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive Adaptive immunity Affinity maturation Alpha antibody Antigen arms race B cell B.1.1.529 B.1.1.7 B.1.351 B.1.617.2 Beta Biliverdin bind binding Cell cognate antigen complementarity-determining region complex conserved coronavirus cryo-EM Donor electron microscopy engage epitope evolutionary arms race Genetic germ line HCDR3 heme high-resolution structure Host Human hydrophobic Infection intermolecular interaction intermolecular interactions knowledge mAb maintain metabolite monoclonal monoclonal antibodies monoclonal antibody mRNA vaccination N-terminal domain neutralize Neutralizing NTD pathogen plasmablast plasmablasts provide respiratory responses reveal SARS-CoV-2 SARS-CoV-2 spike sequence severe acute respiratory syndrome Coronavirus shown spike spike glycoprotein Structure the SARS-CoV-2 the vaccine undergo vaccination Vaccine vaccine immunogen variant variants Viral viral strain viral variant Viral variants [DOI] 10.1128/mbio.03580-21 PMC 바로가기 [Article Type] Article
Accelerating antibiotic discovery through artificial intelligenceReview Article Published on 2021-09-092022-10-04 Journal: Communications Biology [Category] 신약개발, [키워드] antibiotic Antibiotics Antimicrobials Computational drug computational method computer-aided drug design de novo dimension Drug discovery drug-likeness drug-resistant Efficacy evolutionary arms race form inquiry invasive machine learning molecular offer Organisms pathogen peptides proliferation replaced reproducibility Research Stride therapy traits urgency [DOI] 10.1038/s42003-021-02586-0 PMC 바로가기 [Article Type] Review Article
Changing readiness to mitigate SARS-CoV-2 steered long-term epidemic and social trajectoriesArticle Published on 2021-07-062022-10-29 Journal: Scientific Reports [Category] COVID-19, SARS, [키워드] adaptive applied assumed Changing Combination consequence Course decrease Epidemic epidemiological European evolutionary arms race explained feasibility implementation Infectious diseases Iran lockdown measure mitigate Mitigation Mortality mortality rate Mutation pandemic predict Psychological reconstructed reported response responses SARS-CoV-2 SARS-CoV-2 pandemic severity social distancing the disease trajectory turn utility Variability viral infection [DOI] 10.1038/s41598-021-93248-y PMC 바로가기 [Article Type] Article
Autophagy, Unfolded Protein Response, and Neuropilin-1 Cross-Talk in SARS-CoV-2 Infection: What Can Be Learned from Other CoronavirusesSARS-CoV-2 감염에서 자가포식, 전개된 단백질 반응 및 뉴로필린-1 상호작용: 다른 코로나바이러스로부터 배울 수 있는 것Review Published on 2021-06-012022-09-10 Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 진단, 치료제, [키워드] ACE2 activate acute respiratory syndrome angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Antiviral Apoptosis arms race autophagy benefit binding Can caused cell surface receptors cellular cellular response Cellular responses cellular stress response cellular stress responses clearance Coronavirus infection COVID-19 COVID-19 complication COVID-19 complications COVID-19 infection COVID-19 mortality COVID-19 pandemic cytokine Cytokine storm DCs dendritic cell dendritic cells effort endoplasmic reticulum stress ENhance enzyme evolutionary arms race gastrointestinal complication gastrointestinal complications generate health emergency help host cell host cells humans identify immune system increase induce infected cells Infection Innate immunity involved mechanism modulation Mortality mTOR neuropilin Neuropilin-1 NRP1 Other pathogen Pathogens pathway Pathways potential therapeutic target potential therapeutic targets reduce regulated Regulation required respiratory response SARS-CoV-2 SARS-CoV-2 virus SARS-CoV-2 virus infection signaling pathway specific treatment stress responses susceptibility tissue homeostasis Treatment unfolded protein response UPR Viral viral infection Viral particles virus virus infection viruses [DOI] 10.3390/ijms22115992 PMC 바로가기 [Article Type] Review
Novel Immunoglobulin Domain Proteins Provide Insights into Evolution and Pathogenesis of SARS-CoV-2-Related VirusesResearch Article Published on 2020-05-292022-10-29 Journal: mBio [Category] COVID-19, SARS, [키워드] acute respiratory syndrome Alpha Analysis arising attenuate beta-coronavirus beta-CoV Combination comparable Complete coronavirus coronavirus disease CoV COVID-19 COVID-19 pandemic determinant domain Evolution evolutionary arms race Factor Genome Genomic analysis genomic region Health Host Host immune response host immunity hosts identify immune immune evasion immune pressure Immunoglobulin individual insight macro modulate MOST novel Novel coronavirus ORF1a ORF8 outbreak Pathogenesis pathogenicity predicted Protein Proteins Receptor binding domain Region SARS SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 protein SARS-like coronavirus scrutiny sequence severity Structural analysis the Spike Transmission unique virus Virus-host interactions viruses widespread [DOI] 10.1128/mBio.00760-20 PMC 바로가기 [Article Type] Research Article
Host-Pathogen Coevolution and the Emergence of Broadly Neutralizing Antibodies in Chronic Infections숙주-병원체 공진화와 만성 감염에서 광범위하게 중화되는 항체의 출현Research Article Published on 2016-07-212022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adaptation adaptive immune system antibody Antigen antigens arms race binding affinities binding interaction binding interactions cellular changes in chronic chronic infection chronic infections coevolution competition condition Critical determine develop distribution driven by emergence Evolution evolutionary arms race external environment favor flexible focus Frequency Genotype HIV HIV-infected patients Host identify immune immune parameter immune population immune response infections Interaction Lineage mathematical measure molecules Mutation Neutralization assay neutralization assays neutralize Neutralizing antibodies neutralizing antibody occur Organisms parameter Pathogens Population populations provide Rapid resulting Vaccine design Viral virus viruses [DOI] 10.1371/journal.pgen.1006171 PMC 바로가기 [Article Type] Research Article
Comparative Genomic Analysis of Drechmeria coniospora Reveals Core and Specific Genetic Requirements for Fungal Endoparasitism of NematodesDrechmeria coniospora의 비교 게놈 분석을 통해 선충류의 곰팡이 내부 기생충에 대한 핵심 및 특정 유전적 요구 사항이 밝혀졌습니다.Research Article Published on 2016-05-062022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] acquisition adhesion Analysis arms race branch Caenorhabditis elegan Caenorhabditis elegans can be used characterisation characterized Comparative core Dissection elegan elegans Endoparasitism Evolution evolutionary arms race expresse expressed fluorescent reporter genes functional fungal Fungal infection fungi fungus Gene Expression Gene expression analysis gene families gene family Genes Genetic genetic engineering genetic transformation Genome genomic growth Host in silico infect Infection initial Interaction Interference involved kill killing knock-out knowledge lifecycle mechanism Modification molecular mycelia nematode nematodes NETs opens parasitic nematodes parasitism pathogen pathogen’ Phylogenetic analysis probe regulated reported reporter genes Requirement sequenced Specific spore Stage Tolypocladium transformation TRAP virulence [DOI] 10.1371/journal.pgen.1006017 PMC 바로가기 [Article Type] Research Article
Tracing evolutionary relicts of positive selection on eight malaria-related immune genes in mammalsarticle Published on 2015-07-312024-09-01 Journal: Innate Immunity [Category] 말라리아, [키워드] Eutherian evolutionary arms race functional divergence immunogenes malaria Plasmodium Positive selection Recombination [Article Type] article