3D Ex vivo tissue platforms to investigate the early phases of influenza a virus- and SARS-CoV-2-induced respiratory diseasesArticle Published on 2022-12-012022-11-15 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 신약개발, 진단, 치료제, [키워드] animal model animal models Antiviral Cell Cell culture comparable consequence Drug repurposing drug target early phase Ex vivo ex vivo infection Ex vivo infection model Health Host human lung IAV in vitro Infection Inflammatory cytokine Influenza influenza A virus Influenza virus Innate immunity interferon interferon response Intervention introduced lung tissue morbidity and mortality murine outbreak pathophysiological pharmacological platform Respiratory disease respiratory viruses responses SARS-CoV-2 therapy tissue Treatment viral infection viral life cycle viral replication virus while [DOI] 10.1080/22221751.2022.2117101 PMC 바로가기
SARS-CoV-2 Omicron Induces Enhanced Mucosal Interferon Response Compared to other Variants of Concern, Associated with Restricted Replication in Human Lung TissuesSARS-CoV-2 오미크론은 인간 폐 조직의 제한된 복제와 관련하여 우려되는 다른 변이체에 비해 향상된 점막 인터페론 반응을 유도합니다Article Published on 2022-07-212022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, [키워드] Antiviral characterized Clinical severity concern COVID-19 Culture Delta enhanced ex vivo infection Human innate immune innate immune response Interaction interferon interferon response lung lung involvement lung organ culture lung tissue lung tissues mucosal surface mucosal surfaces nasal nasal organ culture omicron organ organ culture pathogenicity question raising reduced Replication respiratory tract response restored Restricted SARS-CoV-2 SARS-CoV-2 variant Signaling susceptibility tissue tissues variant VoC [DOI] 10.3390/v14071583 PMC 바로가기 [Article Type] Article
Distinct Disease Severity Between Children and Older Adults With Coronavirus Disease 2019 (COVID-19): Impacts of ACE2 Expression, Distribution, and Lung Progenitor Cells코로나바이러스 질환 2019(COVID-19)가 있는 어린이와 노인 사이의 뚜렷한 질병 심각도: ACE2 발현, 분포 및 폐 전구 세포의 영향Article Published on 2021-12-062022-09-12 Journal: Clinical Infectious Diseases: An Official Publicat [Category] 진단, [키워드] ACE2 ACE2 expression ACE2 expression and distribution acute respiratory syndrome Adults airway alveolar analyzed angiotensin-converting enzyme 2 biopsies caused cell marker children clinical feature Cohort Combination coronavirus coronavirus disease COVID-19 data sets develop discharged patient disease disease severity distribution ex vivo infection examined expression expression level expression pattern Follow-up Impact Infection Inflammatory response lung lung progenitor cells lung tissue lymphocyte Older older patient older patients Patient patients with COVID-19 patients’ ages. Pneumonia positive cell positive cells progenitor progenitor cell pulmonary tract receptor reduced Region risk factor SARS-CoV-2 SARS-CoV-2 pseudovirus SFTPC single-cell RNA-seq [DOI] 10.1093/cid/ciaa1911 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Infects Hamster TestesCommunication Published on 2021-06-172022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] Affect Cell cells change COVID-19 COVID-19 pandemic Evidence ex vivo infection explained genital hamster histopathological intranasally Lungs mechanism Mild pathology Post-infection raise reduce reproductive tract respiratory virus SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication Sertoli Severe case Teste testes the disease Viral RNA virus replication [DOI] 10.3390/microorganisms9061318 PMC 바로가기 [Article Type] Communication
Ex vivo perfusion of the isolated rat small intestine as a novel model ofSalmonellaenteritis살모넬라 장염의 새로운 모델로서 분리된 쥐 소장의 체외 관류journal-article Published on 2016-01-152024-07-30 Journal: American Journal of Physiology-Gastrointestinal and Liver Physiology [Category] 살모넬라증, [키워드] ex vivo infection intestinal inflammation. Salmonella Yersinia [DOI] 10.1152/ajpgi.00444.2014 [Article Type] journal-article